910114-63-5Relevant articles and documents
T-type calcium channel inhibitor
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Paragraph 0226, (2016/11/02)
The present invention addresses the problem of providing novel compounds that have T-type voltage-gated calcium channel-blocking activity and are useful particularly in treating pain, chronic kidney disease, and atrial fibrillation. Provided are novel tri
PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN
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Page/Page column 26-27, (2012/01/13)
Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D, L2, and Q are defined herein.
Triazinediones as prokineticin 1 receptor antagonists. Part 1: SAR, synthesis and biological evaluation
Ralbovsky, Janet L.,Lisko, Joseph G.,Palmer, Jeffrey M.,Mabus, John,Chevalier, Kristen M.,Schulz, Mark J.,Dyatkin, Alexey B.,Miskowski, Tamara A.,Coats, Steven J.,Hornby, Pamela,He, Wei
scheme or table, p. 2661 - 2663 (2009/12/31)
A series of guanidine triazinediones were identified as potent PK1 receptor antagonists. A compound in this series inhibited the PK1 invoked prosecretory response in rat ileum tissue.