910114-66-8

Basic information

• Product Name: 1,3,5-Triazine-2,4(1H,3H)-dione, 3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-6-(methylthio)-
• CAS NO: 910114-66-8
• Molecular Formula: C19H18FN3O3S
• Molecular Weight: 387.435
• Mol File: 910114-66-8.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1,3,5-Triazine-2,4(1H,3H)-dione, 3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-6-(methylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Triazine-2,4(1H,3H)-dione, 3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-6-(methylthio)-(910114-66-8)
• EPA Substance Registry System: 1,3,5-Triazine-2,4(1H,3H)-dione, 3-[(4-fluorophenyl)methyl]-1-[(4-methoxyphenyl)methyl]-6-(methylthio)-(910114-66-8)

Safety Data

• Hazardous Substances Data: 910114-66-8(Hazardous Substances Data)

Upstream product

• 910114-64-6 5-(methylthio)-3,7-dioxo-1-(4-fluorobenzyl)-2-oxa-4,6,8-triazanon-4-en-9-oic acid methyl ester 
• 910114-65-7 3-(4-fluorobenzyl)-6-(methylthio)-1,3,5-triazine-2,4(1H,3H)-dione 
• 911368-93-9 3-(4-fluoro-benzyl)-6-methylsulfanyl-1H-[1,3,5]triazine-2,4-dione hydrochloride 
• 824-94-2 p-methoxybenzyl chloride 
• 105-13-5 4-Methoxybenzyl alcohol 
• 1616091-83-8 3-(4-fluorobenzyl)-6-thioxo-1,3,5-triazine-2,4-dione 
• 1616091-82-7 1-((4-fluorobenzyl)aminocarbonyl)-3-(ethoxycarbonyl)thiourea 
• 76523-24-5 1-(4-fluorophenyl)methylurea 
• 910114-64-6 5-(methylthio)-3,7-dioxo-1-(4-fluorobenzyl)-2-oxa-4,6,8-triazanon-4-en-9-oic acid methyl ester 
• 910114-63-5 methyl N-({[(4-fluorobenzen-1-yl)methyl]amino}carbonyl)carbamimidothioate 
• 132740-43-3 4-fluorobenzylisocyanate 

Downstream Products

• 1148127-46-1 6-[2-(2-amino-imidazol-1-yl)-ethylamino]-3-(4-fluoro-benzyl)-1-(4-methoxy-benzyl)-1H-[1,3,5]triazine-2,4-dione 
• 910114-06-6 N-{2-[5-(4-fluoro-benzyl)-1-(4-methoxy-benzyl)-4,6-dioxo-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylamino]-ethyl}-N'-amino-guanidine 
• 910114-67-9 6-(2-aminoethylamino)-3-(4-fluorobenzyl)-1-(4-methoxybenzyl)-1,3,5-triazine-2,4(1H,3H)-dione 
• 910114-79-3 [5-(4-fluoro-benzyl)-1-(4-methoxy-benzyl)-4,6-dioxo-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylamino]-acetic acid 

Relevant articles and documents

A new convenient synthetic method and preliminary pharmacological characterization of triazinediones as prokineticin receptor antagonists

A new efficient synthetic method to obtain prokineticin receptor antagonists based on the triazinedione scaffold is described. In this procedure the overall yield improves from 13% to about 54%, essentially for two factors: 1) N-(chlorocarbonyl) isocyanate is no more used, it represents the yield limiting step with an average yield not exceeding 30%. 2) The Mitsunobu reaction is not involved in the new synthetic scheme avoiding the use of time and solvent consuming column chromatography. All synthesized triazinediones were preliminary pharmacologically screened in vivo for their ability to reduce the Bv8-induced thermal hyperalgesia. In this assay all compounds displayed EC 50 values in the picomolar-subpicomolar range, some triazinediones containing a 4-halogen substituted benzyl group in position 5 showed the best activity. The analogues containing a 4-fluorine atom (PC-7) and a 4-bromobenzyl group (PC-25) resulted 10 times more potent than the reference PC-1 that bears a 4-ethylbenzyl group. While the 4-trifluoromethylbenzyl substituted analog (PC-27) was 100 times more potent as compared to PC1.

PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN

Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D, L2, and Q are defined herein.

Prokineticin 1 receptor antagonists

The present invention relates to certain novel compounds of Formula (I): and methods for preparing these compounds, compositions, intermediates and derivatives thereof and for the treatment of prokineticin 1 or prokinetin 1 receptor mediated disorders.