91477-84-8

Basic information

• Product Name: 4-PHENYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE
• Synonyms: 4-Phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine;4,5,6,7-tetrahydro-4-phenyl-Thieno[3,2-c]pyridine;4-phenyl-4H,5H,6H,7H-thieno[3,2-c]pyridine
• CAS NO: 91477-84-8
• Molecular Formula: C₁₃H₁₃NS
• Molecular Weight: 215.31
• Mol File: 91477-84-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 345.5°Cat760mmHg
• Flash Point: 162.8°C
• Appearance: /
• Density: 1.157g/cm³
• Vapor Pressure: 6.12E-05mmHg at 25°C
• CAS DataBase Reference: 4-PHENYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE(91477-84-8)
• EPA Substance Registry System: 4-PHENYL-4,5,6,7-TETRAHYDROTHIENO[3,2-C]PYRIDINE(91477-84-8)

Safety Data

• Hazardous Substances Data: 91477-84-8(Hazardous Substances Data)

Usage

Description

4-Phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine is a significant and widespread structural motif that is present in more than 30 different pharmaceutically active compounds. This unique structure contributes to the diverse range of therapeutic properties and applications of these compounds.

Uses

Used in Pharmaceutical Industry:
4-Phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine is used as a key structural component in the development of various pharmaceutically active compounds. Its presence in these compounds is attributed to its ability to enhance their therapeutic properties and efficacy, making it a valuable asset in the creation of new and improved medications.
The specific applications and reasons for using 4-Phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine in the pharmaceutical industry are not provided in the given materials. However, given its presence in multiple pharmaceutically active compounds, it can be inferred that it plays a crucial role in the development of medications for various therapeutic areas, such as cardiovascular, neurological, and anti-inflammatory treatments, among others.

InChI:InChI=1/C13H13NS/c1-2-4-10(5-3-1)13-11-7-9-15-12(11)6-8-14-13/h1-5,7,9,13-14H,6,8H2/p+1/t13-/m0/s1

Upstream product

• 76356-25-7 4-phenyl-6,7-dihydrothieno<3,2-c>pyridine 
• 213462-06-7 [1-Phenyl-meth-(E)-ylidene]-(2-thiophen-2-yl-ethyl)-amine 
• 30433-91-1 [2-(2-thyenyl)ethyl]amine 
• 100-52-7 benzaldehyde 
• 1254344-23-4 5-formyl-4-phenyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine 
• 65-85-0 benzoic acid 
• 76356-24-6 N-<2-(2-thienyl)ethyl>benzamide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 91477-82-6 2-(4-phenyl-4,5,6,7-tetrahydrothieno<3,2-c>pyridin-5-yl)ethanol 
• 91477-89-3 4-Phenyl-4,6,7,8,9,10-hexahydro-thieno[2,3-g][1,4]oxazonine 
• 91477-85-9 4-phenyl-4,6,7,8,9,10-hexahydrothieno<2,3-g><1,4>oxazonine-8-carbonitrile 
• 91477-90-6 8-methyl-4-phenyl-4,6,7,8,9,10-hexahydrothieno<2,3-g><1,4>oxazonine 
• 1190969-94-8 2-((1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)-1-(4-phenyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone 
• 1224397-17-4 (3R)-3-methyl-4-oxo-4-(4-phenyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)butyric acid methyl ester 
• 1224397-13-0 4-Oxo-4-(4-phenyl-6,7-dihydrothieno[3,2-c]-pyridin-5(4H)-yl)butyric acid 
• 1224391-70-1 4-oxo-4-(4-phenyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)-N-(3-(trifluoromethyl)benzyl)butanamide 
• 1224397-25-4 2-methyl-4-oxo-4-(4-phenyl-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)butyric acid tert-butyl ester 
• 1326273-33-9 N,4-diphenyl-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-carboxamide 

Relevant articles and documents

HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF

Hedgehog acyltransferase (Hhat), a membrane-bound O-acyl transferase (MBOAT) protein, is responsible for the palmitoylation of Shh and is crucial to proper Shh signaling. Hhat inhibitors that are capable of preventing Shh palmitoylation and mitigating Shh

Fused piperidines as a novel class of potent and orally available transient receptor potential melastatin type 8 (TRPM8) antagonists

The transient receptor potential melastatin type 8 (TRPM8) is a nonselective cation channel primarily expressed in a subpopulation of sensory neurons that can be activated by a wide range of stimuli, including menthol, icilin, and cold temperatures (25 °C). Antagonism of TRPM8 is currently under investigation as a new approach for the treatment of pain. As a result of our screening efforts, we identified tetrahydrothienopyridine 4 as an inhibitor of icilin-induced calcium influx in CHO cells expressing recombinant rat TRPM8. Exploration of the structure-activity relationships of 4 led to the identification of a potent and orally bioavailable TRPM8 antagonist, tetrahydroisoquinoline 87. Compound 87 demonstrated target coverage in vivo after oral administration in a rat pharmacodynamic model measuring the prevention of icilin-induced wet-dog shakes (WDS).

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.