91487-86-4

Basic information

• Product Name: (S)-Bifonazole
• Synonyms: (S)-Bifonazole;1H-Imidazole, 1-[(S)-[1,1'-biphenyl]-4-ylphenylmethyl]-
• CAS NO: 91487-86-4
• Molecular Formula: C22H18 N2
• Molecular Weight: 0
• Mol File: 91487-86-4.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-Bifonazole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-Bifonazole(91487-86-4)
• EPA Substance Registry System: (S)-Bifonazole(91487-86-4)

Safety Data

• Hazardous Substances Data: 91487-86-4(Hazardous Substances Data)

Usage

Description

(S)-Bifonazole is an antifungal medication that belongs to the imidazole class of drugs. It is specifically designed for topical application to treat a variety of skin fungal infections. (S)-Bifonazole works by inhibiting the synthesis of ergosterol, a vital component of fungal cell membranes, which leads to the disruption of fungal growth and reproduction. Known for its effectiveness and safety, (S)-Bifonazole is characterized by minimal systemic absorption and a low risk of adverse effects, making it a preferred choice for treating superficial fungal infections.

Uses

Used in Dermatology:
(S)-Bifonazole is used as a topical antifungal agent for the treatment of various skin fungal infections, such as athlete's foot, ringworm, and jock itch. Its application helps in inhibiting the synthesis of ergosterol, which is essential for the integrity of fungal cell membranes, thereby disrupting the growth and reproduction of the fungus and leading to the clearance of the infection.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (S)-Bifonazole is utilized as an active ingredient in the formulation of antifungal medications. Its incorporation into creams, ointments, or lotions allows for targeted treatment of skin fungal infections with minimal systemic absorption, ensuring a low risk of adverse effects and high patient compliance.

Upstream product

• 162824-42-2 (R,S)-1-<α-(4-Biphenylyl)benzyl>imidazole-4,5-dicarboxylic acid 
• 288-32-4 1H-imidazole 
• 7598-80-3 4-phenylbenzhydrol 
• 162824-36-4 1-<α-(4-Biphenylyl)benzyl>imidazole-4,5-dicarbonitrile 
• 7515-73-3 4-(chlorophenylmethyl)-1,1'-biphenyl 
• 18156-74-6 1-(Trimethylsilyl)imidazole 
• 530-62-1 1,1'-carbonyldiimidazole 
• 768-32-1 trimethylphenylsilane 
• 1063965-82-1 (4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)phenyl)(phenyl)methanone 
• 2128-93-0 biphenyl-4-yl-phenyl-methanone 
• 101-81-5 Diphenylmethane 
• 60047-92-9 4-phenyl-benzhydryl bromide 
• 613-42-3 4-benzylbiphenyl 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 

Relevant articles and documents

Controlling Multiple Active Sites on Pd?CeO2 for Sequential C?C Cross-coupling and Alcohol Oxidation in One Reaction System

Ceria (CeO2)-supported metal catalysts have been widely utilized for various single-step chemical transformations. However, using such catalysts for a multistep organic reaction in one reaction system has rarely been achieved. Here, we investigate multiple active sites on Pd?CeO2 catalysts and optimize them for a multistep reaction of C?C cross-coupling and alcohol oxidation. Atomic-level imaging and spectroscopic studies reveal that metallic Pd0 and Pd?CeO2 interface are active sites on Pd?CeO2 for C?C cross-coupling and oxidation, respectively. These active sites are controlled under the structural evolution of Pd?CeO2 during reductive heat-treatments. Accordingly, we found that optimally reduced Pd?CeO2 catalysts containing ～1.5 nm-sized Pd nanoclusters with both sites in balance are ideal for multistep chemical transformations in one reaction system. Our strategy to design supported metal catalysts leads to one-pot sequential synthetic protocols for pharmaceutical building blocks.

Preparation method of para-substituted aryl compound

The invention discloses a preparation method of a para-substituted aryl compound shown as a formula (I) which is described in the specfication. The preparation method is characterized by comprising the following step of: subjecting an aryl sulfonium salt shown as a formula (II) which is described in the specfication and boride to a coupling reaction in a solvent in an inert atmosphere under the action of alkali and a palladium catalyst to obtain the para-substituted aryl compound. According to the method, mono-substituted aromatic hydrocarbon is taken as a substrate, the aryl sulfonium salt isconstructed in situ, and the palladium catalyst catalyzes the aryl sulfonium salt constructed in situ to undergo the Suzuki-Miyaura coupling reaction, so a mono-substituted aromatic hydrocarbon para-arylation or alkenylation product is constructed quickly and efficiently. The method is mild in conditions, high in substrate universality and wide in tolerance of a heterocyclic coupling substrate.

Gold-Catalyzed Oxidative Biaryl Cross-Coupling of Organometallics

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