918148-53-5

Basic information

• Product Name: (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester
• Synonyms: (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester
• CAS NO: 918148-53-5
• Molecular Weight: 250.295
• Mol File: 918148-53-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester(918148-53-5)
• EPA Substance Registry System: (S)-3-Acetoxy-5-phenyl-pentanoic acid methyl ester(918148-53-5)

Safety Data

• Hazardous Substances Data: 918148-53-5(Hazardous Substances Data)

Upstream product

• 108-05-4 vinyl acetate 
• 129880-16-6 3-hydroxy-5-phenyl-pentanoic acid methyl ester 
• 30414-58-5 methyl 3-oxo-5-phenylpentanoate 
• 100-39-0 benzyl bromide 
• 105-45-3 acetoacetic acid methyl ester 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 768-56-9 4-Phenylbut-1-ene 
• 201230-82-2 carbon monoxide 
• 64-19-7 acetic acid 

Downstream Products

• 182950-95-4 (S)-5-hydroxy-3-oxo-7-phenyl-heptanoic acid tert-butyl ester 
• 182950-96-5 (6S)-6-(2-phenylethyl)dihydropyran-2,4⁽³⁾-dione 
• 587-63-3 7,8-dihydrokawain 
• 118133-69-0 (3S) methyl 3-hydroxy-5-phenylpentanoate 

Relevant articles and documents

Asymmetric Palladium-Catalyzed Oxycarbonylation of Terminal Alkenes: Efficient Access to β-Hydroxy Alkylcarboxylic Acids

A novel PdII-catalyzed enantioselective oxycarbonylation of alkenes has been established. The ligand with an ethyl group at the C-6 position of Pyox plays a significant role in the intermolecular oxypalladation process, leading to high reactivity and excellent enantioselective control. Compared to the conventional methods, the reaction itself features alkenes as easily prepared starting materials, mild and operationally simple reaction conditions, and insensitivities to air and water. Moreover, this method allows for broad alkene substrate scope, excellent regio- and enantioselectivities, scalabilities and a wide array of applications, and provides a useful route for the convenient and straightforward synthesis of chiral β-hydroxy alkylcarboxylic acids/esters.

Chemoenzymatic synthesis of enantiomerically enriched kavalactones

Lipase-mediated kinetic resolution of methyl-3-hydroxy-5-phenylpentanoate and (6E)-ethyl 5-hydroxy-3-oxo-7-phenylhept-6-enoate is described in high enantiomeric excess and good yields. The effect of different lipases in different solvents has been screened using different acylating agents. This protocol has been extended for the preparation of enantiomerically pure biologically important kavalactones.