94341-53-4Relevant articles and documents
Synthesis, Antimicrobial Activity, and Molecular Docking of Benzoic Hydrazide or Amide Derivatives Containing a 1,2,3-Triazole Group as Potential SDH Inhibitors
Ding, Yue,Zhang, Ling,Yang, Song,Li, Zhong,Wang, Pei-Yi
, p. 1319 - 1330 (2021)
The present study was carried out in an attempt to synthesize a new class of antimicrobial agents containing a 1,2,3-triazole motif formed by classical copper catalyzed click chemistry. Antifungal bioassay results showed that five compounds 5a, 5e, 5h, 5j
Inverted positioning of dnmt1 inhibitor in the active site of dnmt1 caused by hydrophobicity/hydrophilicity of the terminal structure
Kondo, Takeshi,Kubo, Yuhei,Tojo, Toshifumi,Yuasa, Makoto
, p. 2372 - 2378 (2021/12/16)
DNA (cytosine-5)-methyltransferase 1 (DNMT1) is one of the enzymes that regulate DNA modification. It has been demonstrated that overexpression of DNMT1 is associated with the development of cancer, making DNMT1 an attractive molecular target for cancer t
MTOR/HDAC dual inhibitor and application thereof
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Paragraph 0141-0144, (2020/11/12)
The invention discloses an mTOR/HDAC dual inhibitor and application thereof, and the dual inhibitor has dual inhibition effects of mTOR and HDAC, has better curative effect than the mTOR inhibitor, and can be used for preparing anti-tumor and anti-idiopat