18469-52-8

Basic information

• Product Name: Methyl 4-(aminomethyl)benzoate
• Synonyms: BUTTPARK 33\11-77;4-(AMINOMETHYL)BENZOIC ACID METHYL ESTER;4-(AMINOMETHYL)BENZOIC ACID METHYL ESTER HYDROCHLORIDE;4-METHOXYCARBONYL-BENZYLAMINE HYDROCHLORIDE;4-Aminomethylbenzoic acid methyl ester(HCl);Methyl 4-(aminomethyl)benzoate;Methyl 4-(aminomethyl);Benzoic acid, 4-(aminomethyl)-, methyl ester
• CAS NO: 18469-52-8
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 201.65
• Product Categories: Aromatic Esters;Aminomethyl's;Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 18469-52-8.mol
• Article Data: 56

Chemical Properties

• Melting Point: 243 °C (dec.)(lit.)
• Boiling Point: 278.699 °C at 760 mmHg
• Flash Point: 138.116 °C
• Appearance: /
• Density: 1.121 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.67±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-(aminomethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-(aminomethyl)benzoate(18469-52-8)
• EPA Substance Registry System: Methyl 4-(aminomethyl)benzoate(18469-52-8)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 18469-52-8(Hazardous Substances Data)

Usage

General Description

Methyl 4-(aminomethyl)benzoate is an organic compound with the molecular formula C9H11NO2. It is often used in the synthesis of pharmaceuticals and is known for its wide range of biological activities. Methyl 4-(aminomethyl)benzoate has been found to exhibit antimicrobial, anti-inflammatory, and analgesic properties, making it a valuable compound in drug development. It is commonly used as a reagent in organic synthesis and as an intermediate in the production of various pharmaceuticals. The compound has also been studied for its potential in the treatment of various conditions, including cancer and neurodegenerative diseases. Overall, Methyl 4-(aminomethyl)benzoate is a versatile and important chemical in the field of medicinal chemistry.

InChI:InChI=1/C9H11NO2.ClH/c1-12-9(11)8-4-2-7(6-10)3-5-8;/h2-5H,6,10H2,1H3;1H

Upstream product

• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 94341-53-4 methyl 4-(azidomethyl)benzoate 
• 67-56-1 methanol 
• 56-91-7 p-aminomethylbenzoic acid 
• 2417-73-4 methyl 2-bromomethylbenzoate 
• 34211-05-7 methyl 4-((1,3-dioxoisoindolin-2-yl)methyl)benzoate 
• 34040-64-7 p-methyloxycarbonylbenzyl chloride 
• 1325206-81-2 methyl 4-(((((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)oxy)carbonyl)amino)methyl)benzoate 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 1377451-52-9 2-({[4-(methoxycarbonyl)phenyl]methyl}carbamoyl)benzoic acid 
• 1126-46-1 Methyl 4-chlorobenzoate 
• 42967-55-5 monomethyl monopotassium terephthalate 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 

Downstream Products

• 133052-65-0 4-[(5-Fluoro-2-nitro-phenylamino)-methyl]-benzoic acid methyl ester 
• 133052-61-6 methyl 4-<<(4-fluoro-2-nitrophenyl)amino>methyl>benzoate 
• 130620-73-4 4-{[(S)-2-tert-Butoxycarbonylamino-3-(5-oxo-2,5-dihydro-isoxazol-4-yl)-propionylamino]-methyl}-benzoic acid methyl ester 
• 66801-18-1 N-(4-methoxycarbonylbenzyl)-4-methylbenzenesulfonamide 
• 1571-08-0 methyl 4-formylbenzoate 
• 120157-96-2 methyl 4-[N-(tert-butoxycarbonyl)aminomethyl]benzoate 
• 133052-67-2 methyl 4-N-(2-nitrophenyl)aminomethylbenzoate 
• 172036-06-5 4-[3-(4-{2-[(2-{[2-(Bis-methoxycarbonylmethyl-amino)-ethyl]-methoxycarbonylmethyl-amino}-ethyl)-methoxycarbonylmethyl-amino]-2-methoxycarbonyl-ethyl}-phenyl)-ureidomethyl]-benzoic acid methyl ester 
• 172036-05-4 4-[3-(4-{2-[(2-{[2-(Bis-methoxycarbonylmethyl-amino)-ethyl]-methoxycarbonylmethyl-amino}-ethyl)-methoxycarbonylmethyl-amino]-2-methoxycarbonyl-ethyl}-phenyl)-thioureidomethyl]-benzoic acid methyl ester 
• 131137-03-6 methyl 4‐[(benzylideneamino)methyl]benzoate 
• 180397-75-5 methyl (N)-4-(((4-(methoxycarbonyl)benzyl)imino)methyl)benzoate 
• 198065-80-4 methyl 4-[[N-(1-iminopentyl)amino]methyl]benzoate 
• 198065-81-5 4-[(benzimidoyl-amino)-methyl]-benzoic acid methyl ester 
• 265311-88-4 4-{[(5-hydroxy-1H-indole-2-carbonyl)-amino]-methyl}-benzoic acid methyl ester 

Relevant articles and documents

A novel harmine derivative, N-(4-(hydroxycarbamoyl)benzyl)-1-(4- methoxyphenyl)-9H-pyrido[3,4-b]indole-3-carboxamide (HBC), as histone deacetylase inhibitor: in vitro antiproliferation, apoptosis induction, cell cycle arrest, and antimetastatic effects

This study aims to design and synthesize a novel harmine derivative N-(4-(hydroxycarbamoyl) benzyl)-1-(4-methoxyphenyl)-9H-pyrido [3,4-b]indole-3-carboxamide (HBC) as histone deacetylase (HDAC) inhibitor, and evaluate its antitumor activities and anti-met

Second-Generation Meridianin Analogues Inhibit the Formation of Mycobacterium smegmatis Biofilms and Sensitize Polymyxin-Resistant Gram-Negative Bacteria to Colistin

Drug-resistant bacteria are rapidly becoming a significant problem across the globe. One element that factors into this crisis is the role played by bacterial biofilms in the recalcitrance of some infections to the effects of conventional antibiotics. Bacteria within a biofilm are highly tolerant of both antibiotic treatment and host immune responses. Biofilms are implicated in many chronic infections, including tuberculosis, in which they can act as bacterial reservoirs, requiring an arduous antibiotic regimen to eradicate the infection. A separate, compounding problem is that antibiotics once seen as last-resort drugs, such as the polymyxin colistin, are now seeing more frequent usage as resistance to front-line drugs in Gram-negative bacteria becomes more prevalent. The increased use of such antibiotics inevitably leads to an increased frequency of resistance. Drugs that inhibit biofilms and/or act as adjuvants to overcome resistance to existing antibiotics will potentially be an important component of future approaches to antibacterial treatment. We have previously demonstrated that analogues of the meridianin natural product family possess adjuvant and antibiofilm activities. In this study, we explore structural variation of the lead molecule from previous studies, and identify compounds showing both improved biofilm inhibition potency and synergy with colistin.

Phthalazine derivative, preparation method and applications thereof

The invention discloses a phthalazine derivative, a preparation method and applications thereof, and belongs to the field of medicinal chemistry, wherein the phthalazine derivative prepared by the invention is a good PARP and HDAC double-target inhibitor.