66801-18-1

Basic information

• Product Name: Benzoic acid, 4-[[[(4-methylphenyl)sulfonyl]amino]methyl]-, methyl ester
• CAS NO: 66801-18-1
• Molecular Formula: C16H17NO4S
• Molecular Weight: 319.381
• Mol File: 66801-18-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[[(4-methylphenyl)sulfonyl]amino]methyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[[(4-methylphenyl)sulfonyl]amino]methyl]-, methyl ester(66801-18-1)
• EPA Substance Registry System: Benzoic acid, 4-[[[(4-methylphenyl)sulfonyl]amino]methyl]-, methyl ester(66801-18-1)

Safety Data

• Hazardous Substances Data: 66801-18-1(Hazardous Substances Data)

Upstream product

• 18469-52-8 methyl 4-(aminomethyl)benzoate 
• 6232-11-7 methyl 4-(aminomethyl)benzoate hydrochloride 
• 98-59-9 p-toluenesulfonyl chloride 
• 6908-41-4 4-(methoxycarbonyl)benzyl alcohol 
• 70-55-3 toluene-4-sulfonamide 
• 94341-53-4 methyl 4-(azidomethyl)benzoate 

Downstream Products

• 1211547-71-5 C₂₆H₃₇NO₅SSi 
• 49742-56-5 methyl 4-(4-tolyl)benzoate 
• 70539-49-0 methyl 4-(((N,4-dimethylphenyl)sulfonamido)methyl)benzoate 

Relevant articles and documents

Direct Sulfonamidation of Primary and Secondary Benzylic Alcohols Catalyzed by a Boronic Acid/Oxalic Acid System

The direct sulfonamidation of primary and secondary benzylic alcohols catalyzed by a 2,3,4,5-tetrafluorophenylboronic acid/oxalic acid co-catalytic system was examined. The reaction proceeds under mild conditions with readily available starting materials and has been shown to be gram-scalable without significant decrease of yield. Both primary and secondary benzylic alcohols were evaluated and afforded the desired sulfonamide products with good to excellent yields.

METHOD FOR THE METAL-FREE PREPARATION OF A BIARYL BY A PHOTOSPLICING REACTION AND THEIR USES

The present invention relates to a method for the metal-free preparation of a biaryl compound by a photosplicing reaction and its use in the preparation of chemical compounds, preferably of active ingredients e.g. in the fields of pharmaceuticals and agrochemicals. In particular, it refers to a method for the regiocontrolled preparation of a biaryl compound of formula (I): Ar-Ar' by photochemically reacting a precursor compound of formula (II): Ar-L-Ar' to form a biaryl compound of general formula: Ar-L-Ar' (II) → Ar-Ar' (I) wherein Ar and Ar', independently of each other, represent an unsubstituted or substituted C6-C20 aryl group or a heteroaryl group with 5–20 ring atoms selected from carbon, nitrogen, oxygen and sulfur, and L represents a group –X–Y–Z– as defined herein. The biaryl compounds are generally suitable as intermediates or key building blocks in a very broad spectrum of organic chemical syntheses and their respective utilities. Their use within the field of synthesis of active ingredients is an aspect of the invention, and their use in the preparation of pharmaceutically active ingredients is particularly preferred.

Simple and versatile catalytic system for N-alkylation of sulfonamides with various alcohols

"Chemical Equation Presented" A simple and versatile catalytic system for N-alkylation of sulfonamides with various alcohols based on a catalytic hydrogen transfer reaction has been developed under a low catalyst loading of [Cp*lrCl2]2 (0.050-1.5 mol %) in the presence of t-BuOK. A variety of N-alkylated sulfonamides were prepared In good to excellent yields. Mechanistic investigations revealed that the key catalytic species in the present system is a sulfonylimido-bridged unsaturated diirldium complex [(Cp*lr)2(μ-NTs)2].