949-98-4

Basic information

• Product Name: 2-Methyl-3-(4-nitrophenyl)propenoic acid
• Synonyms: 2-Methyl-3-(4-nitrophenyl)propenoic acid;2-Propenoic acid, 2-Methyl-3-(4-nitrophenyl)-;ALPHA-METHYL-4-NITROCINNAMIC ACID
• CAS NO: 949-98-4
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.18
• Mol File: 949-98-4.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 348.1°C at 760 mmHg
• Flash Point: 151.5°C
• Appearance: /
• Density: 1.352g/cm³
• Vapor Pressure: 1.93E-05mmHg at 25°C
• Refractive Index: 1.633
• CAS DataBase Reference: 2-Methyl-3-(4-nitrophenyl)propenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-3-(4-nitrophenyl)propenoic acid(949-98-4)
• EPA Substance Registry System: 2-Methyl-3-(4-nitrophenyl)propenoic acid(949-98-4)

Safety Data

• Hazardous Substances Data: 949-98-4(Hazardous Substances Data)

Usage

Description

2-Methyl-3-(4-nitrophenyl)propenoic acid, also known as 4-Nitrochalconic acid, is a chemical compound with the molecular formula C10H9NO4. It is a yellow solid, often used as a starting material for the synthesis of chalcones and related compounds. It is a derivative of chalcone, a type of natural phenol. 2-Methyl-3-(4-nitrophenyl)propenoic acid is known for its anti-inflammatory and antioxidant properties, and has shown potential in various pharmacological applications. Its unique structure and properties make it a valuable tool for chemical and pharmaceutical research.

Uses

Used in Pharmaceutical Industry:
2-Methyl-3-(4-nitrophenyl)propenoic acid is used as a starting material for the synthesis of chalcones and related compounds for its anti-inflammatory and antioxidant properties. It is employed in the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
2-Methyl-3-(4-nitrophenyl)propenoic acid is used as a valuable tool in chemical research for studying the properties and reactions of chalcone derivatives and related compounds. Its unique structure allows for the exploration of new synthetic pathways and the development of novel chemical compounds.

InChI:InChI=1/C10H9NO4/c1-7(10(12)13)6-8-2-4-9(5-3-8)11(14)15/h2-6H,1H3,(H,12,13)/b7-6-

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Relevant articles and documents

Design, synthesis and antitumor activity evaluation of Chrysamide B derivatives

Marine natural products derived from special or extreme environment provide an important source for the development of anti-tumor drugs due to their special skeletons and functional groups. In this study, based on our previous work on the total synthesis and structure revision of the novel marine natural product Chrysamide B, a group of its derivatives were designed, synthesized, and subsequently of which the anti-cancer activity, structure-activity relationships and cellular mechanism were explored for the first time. Compared with Chrysamide B, better anti-cancer performance of some derivatives against five human cancer cell lines (SGC-7901, MGC-803, HepG2, HCT-116, MCF-7) was observed, especially for compound b-9 on MGC-803 and SGC-7901 cells with the IC 50 values of 7.88 ± 0.81 and 10.08 ± 1.08 μM, respectively. Subsequently, cellular mechanism study suggested that compound b-9 treatment could inhibit the cellular proliferation, reduce the migration and invasion ability of cells, and induce mitochondrial-dependent apoptosis in gastric cancer MGC-803 and SGC-7901 cells. Furthermore, the mitochondrial-dependent apoptosis induced by compound b-9 is related with the JAK2/STAT3/Bcl-2 signaling pathway. To conclude, our results offer a new structure for the discovery of anti-tumor lead compounds from marine natural products.

Novel piperazine compound as well as preparation method and application thereof

The structural general formula of a novel piperazine compound is shown in the specification. The invention aims to provide a novel anti-inflammatory drug with high efficiency and low side effect. Because typical marine characteristic skeleton molecules ri

Synthesis of Albicidin Derivatives: Assessing the Role of N-terminal Acylation on the Antibacterial Activity

The peptide antibiotic albicidin, which is synthesized by the plant pathogenic bacterium, Xanthomonas albilineans, represents the most prominent member of a new class of antibacterial gyrase inhibitors. It shows remarkable antibacterial activities against Gram-positive and Gram-negative microorganisms. Its unique structure potentially represents a new lead structure for the development of an antibacterial drug. Here we report the synthesis of 14 albicidin derivatives with structural variations at the N-terminus, primarily investigating the effects of variation of cinnamoyl, phenylpropanoyl, and benzoyl residues. Gyrase inhibition in vitro and determination of minimal inhibitory concentrations were assessed in parallel. Activities in a nanomolar range and the importance of N-acylation were demonstrated.