950598-98-8

Basic information

• Product Name: C₄₀H₄₆F₂N₂O₅Si
• Synonyms: C₄₀H₄₆F₂N₂O₅Si
• CAS NO: 950598-98-8
• Molecular Weight: 700.898
• Mol File: 950598-98-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₄₀H₄₆F₂N₂O₅Si(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₀H₄₆F₂N₂O₅Si(950598-98-8)
• EPA Substance Registry System: C₄₀H₄₆F₂N₂O₅Si(950598-98-8)

Safety Data

• Hazardous Substances Data: 950598-98-8(Hazardous Substances Data)

Upstream product

• 949524-33-8 3,4-bis(4-fluoro-phenyl)-5-formyl-1-isopropyl-N-phenyl-1H-pyrrole-2-carboxamide 
• 147118-35-2 methyl (3R)-3-(tert-butyldimethylsilyloxy)-5-oxo-6-triphenylphosphoranylidenehexanoate 
• 459-46-1 4-Fluorobenzyl bromide 
• 459-57-4 4-fluorobenzaldehyde 
• 1535-41-7 1-fluoro-4-(nitromethyl)benzene 
• 855248-37-2 3,4-bis-(4-fluorophenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 126209-33-4 3,4-bis-(4-fluorophenyl)-1-isopropyl-1H-pyrrole-2-carboxylic acid ethyl ester 
• 126209-32-3 3,4-bis-(4-fluorophenyl)-1H-pyrrole-2-carboxylic acid ethyl ester 
• 1027038-69-2 C₂₁H₁₆ClF₂NO₂ 
• 855248-38-3 3,4-bis-(4-fluoro-phenyl)-5-formyl-1-isopropyl-1H-pyrrole-2-carboxylic acid 

Downstream Products

• 950599-47-0 C₃₄H₃₂F₂N₂O₅ 
• 950599-94-7 C₃₄H₃₄F₂N₂O₅ 
• 950600-21-2 C₃₄H₃₆F₂N₂O₅ 

Relevant articles and documents

Development of a practical synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors

This paper describes the development of an efficient and scalable second generation synthesis of novel, pyrrole-based HMG-CoA reductase inhibitors. Compound 1 was identified as part of a discovery program aimed at finding improved treatments for hypercholesterolemia. Herein, we describe an efficient synthesis of its highly functionalized pyrrole core followed by attachment of the 3,5-dihydroxyhexanoic acid side chain via ylide olefination chemistry.