95269-76-4

Basic information

• Product Name: Benzenepropanoic acid, 4-chloro-b-(4-chlorophenyl)-, ethyl ester
• CAS NO: 95269-76-4
• Molecular Formula: C17H16Cl2O2
• Molecular Weight: 323.219
• Mol File: 95269-76-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Benzenepropanoic acid, 4-chloro-b-(4-chlorophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanoic acid, 4-chloro-b-(4-chlorophenyl)-, ethyl ester(95269-76-4)
• EPA Substance Registry System: Benzenepropanoic acid, 4-chloro-b-(4-chlorophenyl)-, ethyl ester(95269-76-4)

Safety Data

• Hazardous Substances Data: 95269-76-4(Hazardous Substances Data)

Upstream product

• 90-98-2 4,4'-Dichlorobenzophenone 
• 107866-47-7 (4,4'-dichloro-benzhydryl)-malonic acid diethyl ester 
• 782-08-1 chlorobis(4-chlorophenyl)methane 
• 408537-45-1 ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate 
• 408319-17-5 3,3-bis-(4-chloro-phenyl)-3-hydroxy-propionic acid 
• 95269-22-0 ethyl 3,3-bis(4'-chlorophenyl)prop-2-enoate 
• 64-17-5 ethanol 
• 2540-35-4 3,3-bis-(4-chloro-phenyl)-propionic acid 

Downstream Products

• 2540-35-4 3,3-bis-(4-chloro-phenyl)-propionic acid 
• 55010-16-7 3,3-bis(p-chlorophenyl)-propionic acid chloride 

Relevant articles and documents

New orally active diphenylmethyl-based ester analogues of dihydroartemisinin: Synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice

A new series of ester analogues of artemisinin 8a–f, incorporating diphenylmethyl as pharmacologically privileged substructure, and 8g–j have been prepared and evaluated for their antimalarial activity against multidrug-resistant (MDR) Plasmodium yoelii nigeriensis in Swiss mice via oral route. These diphenylmethyl-based ester analogues 8a–f were found to be 2–4 folds more active than the antimalarial drugs β-arteether 4 and artesunic acid 5. Ester 8a, the most active compound of the series, provided complete protection to the infected mice at 24?mg/kg?×?4?days as well as 12?mg/kg?×?4?days, respectively. In this model β-arteether provided 100% and 20% protection at 48?mg/kg?×?4?days and 24?mg/kg?×?4?days, respectively.