408537-45-1

Basic information

• Product Name: ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate
• Synonyms: ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate
• CAS NO: 408537-45-1
• Molecular Weight: 339.218
• Mol File: 408537-45-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate(408537-45-1)
• EPA Substance Registry System: ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate(408537-45-1)

Safety Data

• Hazardous Substances Data: 408537-45-1(Hazardous Substances Data)

Upstream product

• 105-36-2 ethyl bromoacetate 
• 90-98-2 4,4'-Dichlorobenzophenone 

Downstream Products

• 2540-35-4 3,3-bis-(4-chloro-phenyl)-propionic acid 
• 95269-76-4 3,3-bis-(4-chloro-phenyl)-propionic acid ethyl ester 
• 100913-93-7 2-bromo-6-chloro-3-(4-chloro-phenyl)-inden-1-one 
• 855612-27-0 6-chloro-3-(4-chloro-phenyl)-inden-1-one 
• 19772-64-6 2,6-dichloro-3-(4-chloro-phenyl)-inden-1-one 
• 408319-17-5 3,3-bis-(4-chloro-phenyl)-3-hydroxy-propionic acid 
• 95269-22-0 ethyl 3,3-bis(4'-chlorophenyl)prop-2-enoate 
• 19618-36-1 3,3-bis(4-chlorophenyl)acrylic acid 

Relevant articles and documents

DMSO-Enabled Selective Radical O?H Activation of 1,3(4)-Diols

Control of selectivity is one of the central topics in organic chemistry. Although unprecedented alkoxyl-radical-induced transformations have drawn a lot of attention, compared to selective C?H activation, selective radical O?H activation remains less explored. Herein, we report a novel selective radical O?H activation strategy of diols by combining spatial effects with proton-coupled electron transfer (PCET). It was found that DMSO is an essential reagent that enables the regioselective transformation of diols. Mechanistic studies indicated the existence of the alkoxyl radical and the selective interaction between DMSO and hydroxyl groups. Moreover, the distal C?C cleavage was realized by this selective alkoxyl-radical-initiation protocol.