95269-22-0

Basic information

• Product Name: 2-Propenoic acid, 3,3-bis(4-chlorophenyl)-, ethyl ester
• CAS NO: 95269-22-0
• Molecular Formula: C17H14Cl2O2
• Molecular Weight: 321.203
• Mol File: 95269-22-0.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 2-Propenoic acid, 3,3-bis(4-chlorophenyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenoic acid, 3,3-bis(4-chlorophenyl)-, ethyl ester(95269-22-0)
• EPA Substance Registry System: 2-Propenoic acid, 3,3-bis(4-chlorophenyl)-, ethyl ester(95269-22-0)

Safety Data

• Hazardous Substances Data: 95269-22-0(Hazardous Substances Data)

Upstream product

• 2642-81-1 1,1-bis(p-chlorophenyl)ethene 
• 109-94-4 formic acid ethyl ester 
• 106-39-8 bromochlorobenzene 
• 140-88-5 ethyl acrylate 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 90-98-2 4,4'-Dichlorobenzophenone 
• 637-87-6 1-Chloro-4-iodobenzene 
• 408537-45-1 ethyl 3,3-bis(4-chlorophenyl)-3-hydroxypropanoate 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 

Downstream Products

• 2540-35-4 3,3-bis-(4-chloro-phenyl)-propionic acid 
• 1437756-74-5 7-chloro-4-(4-chlorophenyl)-2H-chromen-2-one 
• 23594-02-7 3,3-bis(4-chlorophenyl)acrylaldehyde 
• 462093-66-9 4,4'-(3-chloroprop-1-ene-1,1-diyl)bis(chlorobenzene) 
• 96089-74-6 3,3-bis-(4-chlorophenyl)prop-2-en-1-ol 
• 95269-76-4 3,3-bis-(4-chloro-phenyl)-propionic acid ethyl ester 
• 19618-36-1 3,3-bis(4-chlorophenyl)acrylic acid 
• 181768-48-9 [4,4-Bis-(4-chloro-phenyl)-1-diazo-2-oxo-but-3-enyl]-phosphonic acid dimethyl ester 

Relevant articles and documents

Photoinduced Oxidative Alkoxycarbonylation of Alkenes with Alkyl Formates

A photoinduced oxidative alkoxycarbonylation of alkenes initiated by intermolecular addition of alkoxycarbonyl radicals has been demonstrated. Employing alkyl formates as alkoxycarbonyl radical sources, a range of α,β-unsaturated esters were obtained with good regioselectivity and E selectivity under ambient conditions.

New orally active diphenylmethyl-based ester analogues of dihydroartemisinin: Synthesis and antimalarial assessment against multidrug-resistant Plasmodium yoelii nigeriensis in mice

A new series of ester analogues of artemisinin 8a–f, incorporating diphenylmethyl as pharmacologically privileged substructure, and 8g–j have been prepared and evaluated for their antimalarial activity against multidrug-resistant (MDR) Plasmodium yoelii nigeriensis in Swiss mice via oral route. These diphenylmethyl-based ester analogues 8a–f were found to be 2–4 folds more active than the antimalarial drugs β-arteether 4 and artesunic acid 5. Ester 8a, the most active compound of the series, provided complete protection to the infected mice at 24?mg/kg?×?4?days as well as 12?mg/kg?×?4?days, respectively. In this model β-arteether provided 100% and 20% protection at 48?mg/kg?×?4?days and 24?mg/kg?×?4?days, respectively.

Controlled mono- and double-Heck reaction catalyzed by a dicarbene dipalladium complex

The phosphine-free mono- and double-Heck reaction of terminal olefins with electron-deficient and electron-rich aryl halides (iodides and bromides) is described. These reactions are catalyzed by the dicarbene dipalladium complex 1 by controlling the stoichiometry of the aryl halide and the olefine, the loading of the palladium catalyst, as well as using different base, and with or without additive. The procedure of double-Heck reaction allows β,β- diarylation and β,β′-diarylation of terminal olefins and affords trisubstituted olefins in good to excellent yields.