963-16-6 Usage
Description
TRANS-1,2-BIS(PHENYLSULFONYL)ETHYLENE is an organic compound that serves as a key intermediate in the synthesis of various complex organic molecules. It is characterized by its ethylene backbone with two phenylsulfonyl groups attached in a trans configuration, which provides unique reactivity and selectivity in chemical reactions.
Uses
Used in Pharmaceutical Synthesis:
TRANS-1,2-BIS(PHENYLSULFONYL)ETHYLENE is used as a key intermediate in the total synthesis of (+)-7-deoxypancratistatin, a natural product with potential anticancer properties. Its unique structure allows for efficient construction of the complex molecule.
Used in Natural Product Synthesis:
In the field of natural product synthesis, TRANS-1,2-BIS(PHENYLSULFONYL)ETHYLENE is useful for the synthesis of dysiherbaine and neodysiherbaine A, which are bioactive alkaloids with potential applications in medicine.
Used in Catalytic Enantioselective Reactions:
TRANS-1,2-BIS(PHENYLSULFONYL)ETHYLENE has been employed in chiral BINAP-AuTFAand chiral BINAP-AgTFA (TFA = trifluoroacetate anion) -promoted catalytic enantioselective 1,3-dipolar cycloadditions of iminoglycinates. This application highlights its utility in the development of enantioselective synthetic methods, which are crucial for the production of chiral molecules with specific biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 963-16-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,6 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 963-16:
(5*9)+(4*6)+(3*3)+(2*1)+(1*6)=86
86 % 10 = 6
So 963-16-6 is a valid CAS Registry Number.
InChI:InChI=1S/C14H12O4S2/c15-19(16,13-7-3-1-4-8-13)11-12-20(17,18)14-9-5-2-6-10-14/h1-12H/b12-11+
963-16-6Relevant articles and documents
Organocatalytic addition on l,2-bis(sulfone)vinylenes leading to an unprecedented rearrangement
Quintard, Adrien,Alexakis, Alexandre
supporting information; experimental part, p. 11109 - 11113 (2010/04/29)
A study was conducted to demonstrate the use of 1,2-bis(sulfone)vinylenes in enamine catalysis. It was revealed that these sulfones led to a new rearrangement arising from a sulfone shift to the adjacent carbon atom. Investigations also revealed that the use of cheaper (Z)-1,2-bis(sulfone) vinylene lead to full conversion after a short reaction time in dioxane, using H2O as co-catalyst to accelerate the reaction. A careful NMR investigation indicated that the new product was gem-disulfone, which was supported by authentic sample.
Organic semiconductor material and organic electronic device
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Page 22, (2010/11/30)
An organic semiconductor material comprising a compound which has a generalized porphyrin skeleton and which has a molecular structure such that the distance from the generalized porphyrin ring plane to the center of each atom forming the generalized porp
Diazo transfer reaction of 2-(trimethylsilyl)-1,3-dithiane with tosyl azide, carbenic reactivity of transient 2-diazo-1,3-dithiane
Benati, Luisa,Calestani, Gianluca,Nanni, Daniele,Spagnolo, Piero,Volta, Marco
, p. 9269 - 9278 (2007/10/03)
A novel diazo transfer reaction of 2-lithiated 2-(trimethylsilyl)1,3-dithiane with tosyl azide in a 1:20 HMPA-THF mixture furnishes 2-diazo-1,3-dithiane 2, which decomposes at about 0°C to;give in fairly high yield bis(1,3-dithianylidene) 5 through formal
