97329-43-6

Basic information

• Product Name: 1-Bromo-2-chloro-3-methylbenzene
• Synonyms: 1-Bromo-2-chloro-3-methylbenzene;3-Bromo-2-chlorotoluene 98%;1-Bromo-2-chloro-3-methylbenzene, 2-Chloro-3-methylbromobenzene;Benzene, 1-broMo-2-chloro-3-Methyl-;2-Chloro-3-bromotoluene;3-Bromo-2-chloromethylbenzene;3-Bromo-2-chlorotoluene98%
• CAS NO: 97329-43-6
• Molecular Formula: C₇H₆BrCl
• Molecular Weight: 190.45
• Product Categories: Bromine Compounds;Chlorine Compounds
• Mol File: 97329-43-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 226.8°C at 760 mmHg
• Flash Point: 103.5°C
• Appearance: /
• Density: 1.535g/cm³
• Vapor Pressure: 0.12mmHg at 25°C
• Refractive Index: 1.566
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromo-2-chloro-3-methylbenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-chloro-3-methylbenzene(97329-43-6)
• EPA Substance Registry System: 1-Bromo-2-chloro-3-methylbenzene(97329-43-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 97329-43-6(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-chloro-3-methylbenzene is a chemical compound with the molecular formula C7H6BrCl. It is a colorless to light yellow liquid that is insoluble in water but soluble in organic solvents. 1-Bromo-2-chloro-3-methylbenzene is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. It is also used in the production of dyes and as a solvent in various industrial processes. 1-Bromo-2-chloro-3-methylbenzene is a halogenated aromatic compound, and its structural features make it useful in a wide range of chemical reactions and applications. However, it is important to handle it with care, as it can be toxic if inhaled or ingested and can cause irritation to the skin and eyes upon contact.

InChI:InChI=1/C7H6BrCl/c1-5-3-2-4-6(8)7(5)9/h2-4H,1H3

Upstream product

• 570-24-1 2-Methyl-6-nitroaniline 
• 591-17-3 meta-bromotoluene 
• 95-46-5 2-methylphenyl bromide 
• 958990-53-9 6-amino-5-bromo-toluene-3-sulfonic acid 
• 134271-44-6 5-bromo-4-chloro-3-methylbenzenesulfonic acid 
• 7553-56-2 iodine 
• 100-39-0 benzyl bromide 
• 106-38-7 para-bromotoluene 
• 7782-50-5 chlorine 
• 627531-47-9 4-amino-2-chloro-3-methylbromobenzene 
• 7463-35-6 N-(3-chloro-2-methylphenyl)acetamide 
• 125328-80-5 N-(4-bromo-3-chloro-2-methylphenyl)acetamide 

Downstream Products

• 56961-27-4 3-bromo-2-chloro-benzoic acid 
• 1044256-89-4 1-bromo-3-(bromomethyl)-2-chlorobenzene 
• 1227188-09-1 2-chloro-N-(2,6-diisopropylphenyl)-5-methylaniline 
• 1354491-90-9 1-(2-chloro-3-methylphenyl)propan-2-one 
• 156726-03-3 1-benzyl-7-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 1044256-91-8 (3-bromo-2-chlorophenyl)methanamine 
• 915070-53-0 (2-chloro-3-methylphenyl)boronic acid 
• 608-26-4 2-chloro-m-cresol 
• 1799612-08-0 4-bromo-2-chloro-3-methylphenol 
• 1799612-11-5 1-(2-(2-chloro-3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)phenoxy)ethyl)-4-methylpiperazine 

Relevant articles and documents

Palladium-catalyzed borylation of sterically demanding aryl halides with a silica-supported compact phosphane ligand

Immobile but active: A silica-supported "compact" phosphane, Silica-SMAP, can be used in the Pd-catalyzed borylation of aryl chlorides or bromides with bis(pinacolato)diboron (see scheme). The Silica-SMAP/Pd system significantly expands the substrate scope of the borylation toward sterically and electronically challenging aryl halides.

Synthesis of 9,10-dihydrosilaanthracenes with substituents ortho to the silicon and methylene bridges

The generation of 9,10-dihydrosilaanthracenes with substituents on benzo ring carbons, specifically in the 4,5-positions adjacent to the methylene bridge, has been developed.Attempts to prepare the 1,8-isomer where the substituents are adjacent to the silicon bridge are also described.The diarylmethane precursors to the substituted 9,10-dihydrosilaanthracenes required the synthesis of 2,3-dihalotoluenes as well as isomeric 2,6-disubstituted benzaldehydes which were then condensed to diarylmethanols through the Grignard reagents.Ring closure to the 4,5-dimethyl-9,9-dialkyl-9,10-dihydro-9-silaanthracene, I, required the use of Rieke magnesium.The structure of I (alkyl = iPr) was determined and demonstrates that the introduction of substituents adjacent to the methylene bridge causes the dihydrosilaanthracene framework to become nearly planar with a dihedral (or butterfly) angle of 170 deg C.

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase

Pharmaceutical compositions and methods of inhibiting phenylethanolamine N-methyltransferase using 7 and/or 8 substituted 1,2,3,4-tetrahydroisoquinoline compounds.