97927-92-9

Basic information

• Product Name: 7-FLUORO-2-METHYLISATOIC ANHYDRIDE
• Synonyms: 7-FLUORO-2-METHYLISATOIC ANHYDRIDE;4-Fluoro-2-Methyl Isatin Anhydride;7-fluoro-1-methyl-1H-benzo[d][1,3]oxazine-2,4-dione
• CAS NO: 97927-92-9
• Molecular Formula: C₉H₆FNO₃
• Molecular Weight: 195.148
• Mol File: 97927-92-9.mol
• Article Data: 6

Chemical Properties

• Melting Point: 158-159 °C(Solv: dichloromethane (75-09-2))
• Boiling Point: 313.6±44.0 °C(Predicted)
• Appearance: /
• Density: 1.439±0.06 g/cm3(Predicted)
• PKA: -3.40±0.20(Predicted)
• CAS DataBase Reference: 7-FLUORO-2-METHYLISATOIC ANHYDRIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-FLUORO-2-METHYLISATOIC ANHYDRIDE(97927-92-9)
• EPA Substance Registry System: 7-FLUORO-2-METHYLISATOIC ANHYDRIDE(97927-92-9)

Safety Data

• Hazardous Substances Data: 97927-92-9(Hazardous Substances Data)

Upstream product

• 75-44-5 phosgene 
• 128992-62-1 4-fluoro-N-methylanthranilic acid 
• 2252-51-9 2-choro-4-fluorobenzoic acid 
• 321-50-6 7-fluoro-1H-benzo[d][1,3]oxazine-2,4-dione 
• 74-88-4 methyl iodide 
• 446-32-2 4-fluoroanthranilic acid 

Downstream Products

• 154639-75-5 1-(4-fluoro-2-methylaminophenyl)-2-methylsulfinylethanone 
• 76568-02-0 flosequinan 
• 76568-68-8 flosequinoxan 
• 97954-38-6 methyl 4-fluoro-2-(N-methylamino)benzoate 
• 1261594-19-7 3-benzyl-8-fluoro-1-methyl-3,4-dihydro-1H-benzo[d][1,3]diazepine-5(2H)-one 

Relevant articles and documents

Discovery of evodiamine derivatives as potent insecticide candidates

In the search for novel more effective insecticides, natural products could be used as ideal template compounds due to their good environmental compatibility, various bioactivities, unique scaffolds and mode of action. We have found that natural product evodiamine, the main active component from the fruits of Evodia rutaecarpa (Juss.) Benth, displayed obvious insecticidal activities against lepidoptera pests. To continue our research, a series of evodiamine derivatives 3a-3aa were rationally designed and synthesized. The larvicidal activities results indicated that most of target compounds displayed better efficacy than evodiamine, matrine, and rotenone against Mythimna separata, Plutella xylostella and Helicoverpa armigera, among which 3z exhibited excellent larvicidal activities (65% at 2.5 mg/L against M. separata, 75% at 1.0 mg/L against P. xylostella, and 85% 10 mg/L against H. armigera, respectively), much better than evodiamine (0%), matrine (0%), and rotenone (0%). The preliminary structure activity relationships demonstrated that the fluorine atom at the E ring of evodiamine had a positive influence on the larvicidal activity. The calcium imaging experiment studies indicated that 3z could act on the ryanodine receptor (RyR) of M. separata and was an effective calcium activator for RyR.

SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION

The present invention covers aminoquinolone compounds of general formula (I) : in which R1, R2, R3, R4, R5, R6, R7, R8, X and n are as defined herein, methods of prepa

Syntheses of Flosequinan: A Novel 4-Quinolone shown to be useful in Congestive Heart Failure

Two synthetic routes to flosequinan 1 and flosequinoxan 2 are described in which either ring closure of the β-keto sulfoxides 12 or 13 with ortho esters or cyclisation of the anilinoacrylates 23, 28 or 29 are the key steps.