98369-78-9

Basic information

• Product Name: 4-fluoro-α-phenyl benzeneethanol
• Synonyms: 4-fluoro-α-phenyl benzeneethanol
• CAS NO: 98369-78-9
• Molecular Weight: 216.255
• Mol File: 98369-78-9.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 4-fluoro-α-phenyl benzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-α-phenyl benzeneethanol(98369-78-9)
• EPA Substance Registry System: 4-fluoro-α-phenyl benzeneethanol(98369-78-9)

Safety Data

• Hazardous Substances Data: 98369-78-9(Hazardous Substances Data)

Upstream product

• 100-42-5 styrene 
• 33756-42-2 tri-p-fluorophenylstibine 
• 100-52-7 benzaldehyde 
• 18511-62-1 4-fluorostyrene oxide 
• 98-80-6 phenylboronic acid 
• 371-40-4 4-fluoroaniline 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 459-04-1 4-Fluorophenylacetyl chloride 
• 405-50-5 p-Fluorophenylacetic acid 
• 1416889-59-2 1-(dimethyl(phenyl)silyl)-2-(4-fluorophenyl)ethanone 
• 1657-46-1 cis-4-fluorostilbene 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 7116-50-9 1-fluoro-4-methoxymethyl-benzene 
• 98369-94-9 1-Fluoro-4-methylselanylmethyl-benzene 

Downstream Products

• 1016896-29-9 (R)-1-acetoxy-1-phenyl-2-(4-fluorophenyl)ethane 
• 1422191-18-1 (S)-1-butyryloxy-1-phenyl-2-(4-fluorophenyl)ethane 

Relevant articles and documents

Heterogeneous visible-light-induced Meerwein hydration reaction of alkenes in water using mpg-C3N4 as a recyclable photocatalyst

A green and efficient visible light induced Meerwein hydration reaction of alkenes in aqueous medium using mpg-C3N4 as a recyclabe photocatalyst has been disclosed. This protocol provides a direct approach for the preparation of racemic alcohols via a free radical mechanism. Water acted as both a solvent and a reagent without any additives or co-solvents. The metal-free heterogeneous semiconductor is found to be fully recyclable at least 5 times without any significant reduction in activity. The Meerwein hydration reaction has an excellent substrate scope and gave the desired products in moderate to high yields. Furthermore, this reaction could be carried out under solar light irradiation and is applicable for large-scale reactions with satisfactory results.

Enantioselective 1,2-Anionotropic Rearrangement of Acylsilane through a Bisguanidinium Silicate Ion Pair

Highly enantioselective bisguanidinium-catalyzed tandem rearrangements of acylsilanes are reported. The acylsilanes were activated via an addition of fluoride on the silicon to form a penta-coordinate anionic silicate intermediate. The silicate then underwent alkyl or aryl group migration from the silicon atom to the neighboring carbonyl carbon atom (1,2-anionotropic rearrangement), followed by [1,2]-Brook rearrangement to provide the secondary alcohols in high yields with excellent enantioselectivities (up to 95% ee). The isolation of an α-silylcarbinol intermediate as well as DFT calculations revealed that the 1,2-anionotropic rearrangement occurred via a bisguanidinium silicate ion pair, which is the stereodetermining step. The chiral center formed is then retained without inversion through the subsequent [1,2]-Brook rearrangement. Crotyl acylsilanes were smoothly transformed into homoallylic linear crotyl alcohols with retention of E/Z geometry, and no branched alcohols were detected. This clearly suggested that the 1,2-anionotropic rearrangement occurred through a three-membered instead of a five-membered transition state.

Nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids

Let's get multicatalytic! A Ni0 catalyst complexed with a biaryldialkyl monophosphine ligand facilitates C-C bond formation between styrenyl epoxides and aryl boronic acids (see scheme). X-ray analysis of a catalytically active nickel/ligand complex supports a redox pathway involving C sp 3-O bond activation. A variety of α-substituted alcohols were generated with good reaction efficiency by a multicatalytic sequence. Copyright