L-Glutamic acid,N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-

1. 1.1 IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name Product Number Brand CAS-No. : : : : Aminopterin 09328 Fluka 54-62-6 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Manufacture of substances 2. 2.1 2.2 HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Acute toxicity, Oral (Category 2) Reproductive toxicity (Category 1B) Classification according to EU Directives 67/548/EEC or 1999/45/EC May cause harm to the unborn child. Very toxic if swallowed. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram Signal word Hazard statement(s) H300 H360 Precautionary statement(s) P201 P264 P301 + P310 P308 + P313 Danger Fatal if swallowed. May damage fertility or the unborn child. Obtain special instructions before use. Wash hands thoroughly after handling. IF SWALLOWED: Immediately call a POISON CENTER or doctor/ physician. IF exposed or concerned: Get medical advice/ attention. Supplemental Hazard none Statements According to European Directive 67/548/EEC as amended. Hazard symbol(s) R-phrase(s) R61 R28 S-phrase(s) S53 S28 S36/37 S45 May cause harm to the unborn child. Also very toxic if swallowed. Avoid exposure - obtain special instructions before use. After contact with skin, wash immediately with plenty of soap and water. Wear suitable protective clothing and gloves. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). Restricted to professional users. 2.3 3. 3.1 Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms Formula Molecular Weight Component : : : 4-Amino-PGA 4-Aminopteroyl-L-glutamic acid 4-Aminofolic acid C19H20N8O5 440,41 g/mol Concentration N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid CAS-No. EC-No. 54-62-6 200-209-9 - 4. 4.1 4.2 4.3 FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed Blood disorders, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Indication of any immediate medical attention and special treatment needed no data available 5. 5.1 5.2 5.3 5.4 6. 6.1 6.2 6.3 6.4 7. 7.1 7.2 7.3 8. 8.1 8.2 FIRE-FIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx) Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary. Further information no data available ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. HANDLING AND STORAGE Precautions for safe handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8 °C Light sensitive. Store under inert gas. Air sensitive. Specific end uses no data available EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling the product. Personal protective equipment Eye/face protection Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Body Protection Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). 9. 9.1 PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties a) b) c) d) e) f) g) h) Appearance Odour Odour Threshold pH Melting point/freezing point Initial boiling point and boiling range Flash point Evaporation rate Form: solid no data available no data available no data available Melting point/range: 228 - 235 °C - dec. no data available no data available no data available i) Flammability (solid, gas) no data available j) k) l) Upper/lower flammability or explosive limits Vapour pressure Vapour density no data available no data available no data available m) Relative density no data available n) o) p) q) r) s) t) Water solubility Partition coefficient: n- octanol/water Autoignition temperature Decomposition temperature Viscosity Explosive properties Oxidizing properties no data available no data available no data available no data available no data available no data available no data available 9.2 Other safety information no data available 10. 10.1 10.2 10.3 10.4 10.5 10.6 11. 11.1 STABILITY AND REACTIVITY Reactivity no data available Chemical stability no data available Possibility of hazardous reactions no data available Conditions to avoid Light. Incompatible materials Strong oxidizing agents Hazardous decomposition products Other decomposition products - no data available TOXICOLOGICAL INFORMATION Information on toxicological effects Acute toxicity Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity IARC: No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC. Reproductive toxicity May cause congenital malformation in the fetus. Presumed human reproductive toxicant Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation Ingestion Skin Eyes May be harmful if inhaled. May cause respiratory tract irritation. May be fatal if swallowed. May be harmful if absorbed through skin. May cause skin irritation. May cause eye irritation. Signs and Symptoms of Exposure Blood disorders, To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional Information RTECS: MA1050000 12. 12.1 12.2 12.3 12.4 12.5 12.6 13. 13.1 14. 14.1 ECOLOGICAL INFORMATION Toxicity no data available Persistence and degradability no data available Bioaccumulative potential no data available Mobility in soil no data available Results of PBT and vPvB assessment no data available Other adverse effects no data available DISPOSAL CONSIDERATIONS Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. TRANSPORT INFORMATION UN number 14.2 ADR/RID: 2811 UN proper shipping name IMDG: 2811 IATA: 2811 ADR/RID: IMDG: IATA: TOXIC SOLID, ORGANIC, N.O.S. (N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L- glutamic acid) TOXIC SOLID, ORGANIC, N.O.S. (N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L- glutamic acid) Toxic solid, organic, n.o.s. (N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid) 14.3 Transport hazard class(es) 14.4 14.5 14.6 15. ADR/RID: 6.1 Packaging group ADR/RID: I Environmental hazards ADR/RID: no Special precautions for user no data available REGULATORY INFORMATION IMDG: 6.1 IMDG: I IMDG Marine pollutant: no IATA: 6.1 IATA: I IATA: no This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006. 15.1 15.2 Safety, health and environmental regulations/legislation specific for the substance or mixture no data available Chemical Safety Assessment no data available 16. OTHER INFORMATION Further information The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Lookchem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.

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