*** CHEMICAL IDENTIFICATION ***
RTECS NUMBER : RQ5832380
CHEMICAL NAME : 2(3H)-Oxazolone,
4-(4-fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-pipera
zinyl)ethyl)-
CAS REGISTRY NUMBER : 52867-74-0
BEILSTEIN REFERENCE NO. : 1182380
LAST UPDATED : 199612
DATA ITEMS CITED : 8
MOLECULAR FORMULA : C22-H24-F-N3-O3
MOLECULAR WEIGHT : 397.49
COMPOUND DESCRIPTOR : Drug
SYNONYMS/TRADE NAMES :
* 4-(4-Fluorophenyl)-5-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-2(3H)-
oxazolone
* LR 511
* Zoloperone
*** HEALTH HAZARD DATA ***
** ACUTE TOXICITY DATA **
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rat
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
TYPE OF TEST : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - mouse
DOSE/DURATION : >2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc.,
Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC
20037) V.6- 1963- Volume(issue)/page/year: 32,2241,1989
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Mammal - dog
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Oral
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
TYPE OF TEST : LD - Lethal dose
ROUTE OF EXPOSURE : Intraperitoneal
SPECIES OBSERVED : Rodent - rabbit
DOSE/DURATION : >1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PHMGBN Pharmacology: International Journal of Experimental and Clinical
Pharmacology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.1-
1968- Volume(issue)/page/year: 15,485,1977
*** END OF RECORD ***
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