1.
1.1
IDENTIFICATION
OF
THE
SUBSTANCE/MIXTURE
AND
OF
THE
COMPANY/UNDERTAKING
Product
identifiers
Product
name
Product
Number
Brand
CAS-No.
:
:
:
:
Phenobarbital
P1636
50-06-6
1.2
Relevant
identified
uses
of
the
substance
or
mixture
and
uses
advised
against
Identified
uses
:
Laboratory
chemicals,
Manufacture
of
substances 2.
2.1
2.2
HAZARDS
IDENTIFICATION
Classification
of
the
substance
or
mixture
Classification
according
to
Regulation
(EC)
No
1272/2008
[EU-GHS/CLP]
Acute
toxicity,
Oral
(Category
3)
Skin
sensitization
(Category
1)
Carcinogenicity
(Category
2)
Reproductive
toxicity
(Category
1B)
Classification
according
to
EU
Directives
67/548/EEC
or
1999/45/EC
May
cause
harm
to
the
unborn
child.
Toxic
if
swallowed.
Limited
evidence
of
a
carcinogenic
effect.
May
cause
sensitization
by
skin
contact.
Label
elements
Labelling
according
Regulation
(EC)
No
1272/2008
[CLP]
Pictogram
Signal
word
Hazard
statement(s)
H301
H317
H351
H360D
Precautionary
statement(s)
P201
P280
-
P1636
Danger
Toxic
if
swallowed.
May
cause
an
allergic
skin
reaction.
Suspected
of
causing
cancer.
May
damage
the
unborn
child.
Obtain
special
instructions
before
use.
Wear
protective
gloves.
P301
+
P310
P308
+
P313
Supplemental
Hazard
IF
SWALLOWED:
Immediately
call
a
POISON
CENTER
or
doctor/
physician.
IF
exposed
or
concerned:
Get
medical
advice/
attention.
none
Statements
Restricted
to
professional
users.
According
to
European
Directive
67/548/EEC
as
amended.
Hazard
symbol(s)
R-phrase(s)
R61
R25
R40
R43
S-phrase(s)
S53
S36/37
S45
May
cause
harm
to
the
unborn
child.
Also
toxic
if
swallowed.
Limited
evidence
of
a
carcinogenic
effect.
May
cause
sensitization
by
skin
contact.
Avoid
exposure
-
obtain
special
instructions
before
use.
Wear
suitable
protective
clothing
and
gloves.
In
case
of
accident
or
if
you
feel
unwell,
seek
medical
advice
immediately
(show
the
label
where
possible).
Restricted
to
professional
users.
2.3
3.
3.1
Other
hazards
-
none
COMPOSITION/INFORMATION
ON
INGREDIENTS
Substances
Synonyms
Formula
Molecular
Weight
Component
Phenobarbital
:
:
:
5-Ethyl-5-phenyl-2,4,6-pyrimidinetrione
5-Ethyl-5-phenylbarbituric
acid
Luminal
C12H12N2O3
232,24
g/mol
Concentration
CAS-No.
EC-No.
50-06-6
200-007-0
-
4.
4.1
4.2
FIRST
AID
MEASURES
Description
of
first
aid
measures
General
advice
Consult
a
physician.
Show
this
safety
data
sheet
to
the
doctor
in
attendance.
If
inhaled
If
breathed
in,
move
person
into
fresh
air.
If
not
breathing,
give
artificial
respiration.
Consult
a
physician.
In
case
of
skin
contact
Wash
off
with
soap
and
plenty
of
water.
Take
victim
immediately
to
hospital.
Consult
a
physician.
In
case
of
eye
contact
Flush
eyes
with
water
as
a
precaution.
If
swallowed
Never
give
anything
by
mouth
to
an
unconscious
person.
Rinse
mouth
with
water.
Consult
a
physician.
Most
important
symptoms
and
effects,
both
acute
and
delayed
can
lead
to
addiction,
Exposure
to
and/or
consumption
of
alcohol
may
increase
toxic
effects.,
respiratory
difficulties,
Constipation.,
Nausea,
Anorexia.,
Vomiting,
Headache,
Drowsiness,
depression,
Skin
-
P1636
disorders,
To
the
best
of
our
knowledge,
the
chemical,
physical,
and
toxicological
properties
have
not
been
thoroughly
investigated.
4.3
5.
5.1
5.2
5.3
5.4
6.
6.1
6.2
6.3
6.4
7.
7.1
7.2
7.3
8.
8.1
8.2
Indication
of
any
immediate
medical
attention
and
special
treatment
needed
no
data
available
FIREFIGHTING
MEASURES
Extinguishing
media
Suitable
extinguishing
media
Use
water
spray,
alcohol-resistant
foam,
dry
chemical
or
carbon
dioxide.
Special
hazards
arising
from
the
substance
or
mixture
Carbon
oxides,
nitrogen
oxides
(NOx)
Nature
of
decomposition
products
not
known.
Carbon
oxides,
nitrogen
oxides
(NOx)
Advice
for
firefighters
Wear
self
contained
breathing
apparatus
for
fire
fighting
if
necessary.
Further
information
no
data
available
ACCIDENTAL
RELEASE
MEASURES
Personal
precautions,
protective
equipment
and
emergency
procedures
Wear
respiratory
protection.
Avoid
dust
formation.
Avoid
breathing
vapors,
mist
or
gas.
Ensure
adequate
ventilation.
Evacuate
personnel
to
safe
areas.
Avoid
breathing
dust.
Environmental
precautions
Prevent
further
leakage
or
spillage
if
safe
to
do
so.
Do
not
let
product
enter
drains.
Methods
and
materials
for
containment
and
cleaning
up
Pick
up
and
arrange
disposal
without
creating
dust.
Sweep
up
and
shovel.
Keep
in
suitable,
closed
containers
for
disposal.
Reference
to
other
sections
For
disposal
see
section
13.
HANDLING
AND
STORAGE
Precautions
for
safe
handling
Avoid
contact
with
skin
and
eyes.
Avoid
formation
of
dust
and
aerosols.Avoid
exposure
-
obtain
special
instructions
before
use.
Provide
appropriate
exhaust
ventilation
at
places
where
dust
is
formed.Normal
measures
for
preventive
fire
protection.
Conditions
for
safe
storage,
including
any
incompatibilities
Store
in
cool
place.
Keep
container
tightly
closed
in
a
dry
and
well-ventilated
place.
Specific
end
uses
no
data
available
EXPOSURE
CONTROLS/PERSONAL
PROTECTION
Control
parameters
Components
with
workplace
control
parameters
Exposure
controls
Appropriate
engineering
controls
Avoid
contact
with
skin,
eyes
and
clothing.
Wash
hands
before
breaks
and
immediately
after
handling
the
product.
-
P1636
Personal
protective
equipment
Eye/face
protection
Face
shield
and
safety
glasses
Use
equipment
for
eye
protection
tested
and
approved
under
appropriate
government
standards
such
as
NIOSH
(US)
or
EN
166(EU).
Skin
protection
Handle
with
gloves.
Gloves
must
be
inspected
prior
to
use.
Use
proper
glove
removal
technique
(without
touching
glove's
outer
surface)
to
avoid
skin
contact
with
this
product.
Dispose
of
contaminated
gloves
after
use
in
accordance
with
applicable
laws
and
good
laboratory
practices.
Wash
and
dry
hands.
The
selected
protective
gloves
have
to
satisfy
the
specifications
of
EU
Directive
89/686/EEC
and
the
standard
EN
374
derived
from
it.
Body
Protection
Complete
suit
protecting
against
chemicals,
The
type
of
protective
equipment
must
be
selected
according
to
the
concentration
and
amount
of
the
dangerous
substance
at
the
specific
workplace.
Respiratory
protection
Where
risk
assessment
shows
air-purifying
respirators
are
appropriate
use
a
full-face
particle
respirator
type
N100
(US)
or
type
P3
(EN
143)
respirator
cartridges
as
a
backup
to
engineering
controls.
If
the
respirator
is
the
sole
means
of
protection,
use
a
full-face
supplied
air
respirator.
Use
respirators
and
components
tested
and
approved
under
appropriate
government
standards
such
as
NIOSH
(US)
or
CEN
(EU).
9.
9.1
PHYSICAL
AND
CHEMICAL
PROPERTIES
Information
on
basic
physical
and
chemical
properties
a)
b)
c)
d)
e)
f)
g)
h)
Appearance
Odour
Odour
Threshold
pH
Melting
point/freezing
point
Initial
boiling
point
and
boiling
range
Flash
point
Evaporation
rate
Form:
solid
Colour:
white
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
i)
Flammability
(solid,
gas)
no
data
available
j)
k)
l)
Upper/lower
flammability
or
explosive
limits
Vapour
pressure
Vapour
density
no
data
available
no
data
available
no
data
available
m)
Relative
density
no
data
available
n)
o)
p)
q)
r)
Water
solubility
Partition
coefficient:
n-
octanol/water
Autoignition
temperature
Decomposition
temperature
Viscosity
no
data
available
no
data
available
no
data
available
no
data
available
no
data
available
-
P1636
s)
t)
Explosive
properties
Oxidizing
properties
no
data
available
no
data
available
9.2
10.
10.1
10.2
10.3
10.4
10.5
10.6
11.
11.1
Other
safety
information
no
data
available
STABILITY
AND
REACTIVITY
Reactivity
no
data
available
Chemical
stability
no
data
available
Possibility
of
hazardous
reactions
no
data
available
Conditions
to
avoid
no
data
available
Incompatible
materials
Strong
oxidizing
agents
Hazardous
decomposition
products
Other
decomposition
products
-
no
data
available
TOXICOLOGICAL
INFORMATION
Information
on
toxicological
effects
Acute
toxicity
LD50
Oral
-
rat
-
162
mg/kg
Skin
corrosion/irritation
no
data
available
Serious
eye
damage/eye
irritation
no
data
available
Respiratory
or
skin
sensitization
May
cause
allergic
skin
reaction.
Germ
cell
mutagenicity
Genotoxicity
in
vitro
-
Hamster
-
Lungs
Sister
chromatid
exchange
Genotoxicity
in
vitro
-
Hamster
-
Lungs
Cytogenetic
analysis
Genotoxicity
in
vitro
-
Human
-
lymphocyte
Cytogenetic
analysis
Genotoxicity
in
vitro
-
Human
-
lymphocyte
Mutation
in
mammalian
somatic
cells.
Genotoxicity
in
vitro
-
rat
-
Liver
DNA
damage
Genotoxicity
in
vitro
-
rat
-
Liver
Unscheduled
DNA
synthesis
Genotoxicity
in
vitro
-
rat
-
Liver
DNA
inhibition
Genotoxicity
in
vitro
-
mouse
-
Embryo
Morphological
transformation.
Genotoxicity
in
vivo
-
rat
-
Oral
Genotoxicity
in
vivo
-
rat
-
Oral
-
P1636
Unscheduled
DNA
synthesis
Genotoxicity
in
vivo
-
rat
-
Intraperitoneal
Genotoxicity
in
vivo
-
mouse
-
Oral
Unscheduled
DNA
synthesis
Genotoxicity
in
vivo
-
mouse
-
Oral
Cytogenetic
analysis
Genotoxicity
in
vivo
-
mouse
-
Oral
Dominant
lethal
test
Carcinogenicity
Carcinogenicity
-
mouse
-
Oral
Tumorigenic:Neoplastic
by
RTECS
criteria.
Lungs,
Thorax,
or
Respiration:Tumors.
Liver:Tumors.
Carcinogenicity
-
rat
-
Oral
Tumorigenic:Equivocal
tumorigenic
agent
by
RTECS
criteria.
Liver:Tumors.
Endocrine:Thyroid
tumors.
Carcinogenicity
-
rat
-
Oral
Tumorigenic:Neoplastic
by
RTECS
criteria.
Endocrine:Thyroid
tumors.
Limited
evidence
of
carcinogenicity
in
animal
studies
IARC:
2B
-
Group
2B:
Possibly
carcinogenic
to
humans
(Phenobarbital)
Reproductive
toxicity
Presumed
human
reproductive
toxicant
May
damage
the
unborn
child.
Reproductive
toxicity
-
rabbit
-
Oral
Effects
on
Fertility:
Post-implantation
mortality
(e.g.,
dead
and/or
resorbed
implants
per
total
number
of
implants).
Effects
on
Embryo
or
Fetus:
Fetal
death.
Effects
on
Fertility:
Litter
size
(e.g.;
#
fetuses
per
litter;
measured
before
birth).
Reproductive
toxicity
-
rabbit
-
Intramuscular
Effects
on
Newborn:
Biochemical
and
metabolic.
Reproductive
toxicity
-
rat
-
Oral
Effects
on
Fertility:
Post-implantation
mortality
(e.g.,
dead
and/or
resorbed
implants
per
total
number
of
implants).
Effects
on
Fertility:
Abortion.
Reproductive
toxicity
-
rat
-
Oral
Effects
on
Newborn:
Viability
index
(e.g.,
#
alive
at
day
4
per
#
born
alive).
Reproductive
toxicity
-
rat
-
Oral
Effects
on
Newborn:
Weaning
or
lactation
index
(e.g.,
#
alive
at
weaning
per
#
alive
at
day
4).
Effects
on
Newborn:
Behavioral.
Reproductive
toxicity
-
rat
-
Subcutaneous
Effects
on
Fertility:
Male
fertility
index
(e.g.,
#
males
impregnating
females
per
#
males
exposed
to
fertile
nonpregnant
females).
Reproductive
toxicity
-
rat
-
Subcutaneous
Effects
on
Newborn:
Physical.
Effects
on
Newborn:
Delayed
effects.
Reproductive
toxicity
-
mouse
-
Oral
Effects
on
Fertility:
Pre-implantation
mortality
(e.g.,
reduction
in
number
of
implants
per
female;
total
number
of
implants
per
corpora
lutea).
Effects
on
Fertility:
Post-implantation
mortality
(e.g.,
dead
and/or
resorbed
implants
per
total
number
of
implants).
Reproductive
toxicity
-
mouse
-
Oral
Effects
on
Newborn:
Growth
statistics
(e.g.,
reduced
weight
gain).
Effects
on
Newborn:
Behavioral.
Reproductive
toxicity
-
mouse
-
Intraperitoneal
Effects
on
Fertility:
Post-implantation
mortality
(e.g.,
dead
and/or
resorbed
implants
per
total
number
of
implants).
Reproductive
toxicity
-
mouse
-
Intraperitoneal
Effects
on
Newborn:
Biochemical
and
metabolic.
-
P1636
Reproductive
toxicity
-
mouse
-
Parenteral
Maternal
Effects:
Uterus,
cervix,
vagina.
Developmental
Toxicity
-
rabbit
-
Oral
Specific
Developmental
Abnormalities:
Musculoskeletal
system.
Specific
Developmental
Abnormalities:
Cardiovascular
(circulatory)
system.
Developmental
Toxicity
-
rabbit
-
Oral
Effects
on
Embryo
or
Fetus:
Cytological
changes
(including
somatic
cell
genetic
material).
Effects
on
Newborn:
Biochemical
and
metabolic.
Developmental
Toxicity
-
rat
-
Intraperitoneal
Effects
on
Embryo
or
Fetus:
Extra
embryonic
structures
(e.g.,
placenta,
umbilical
cord).
Effects
on
Embryo
or
Fetus:
Fetal
death.
Specific
Developmental
Abnormalities:
Other
developmental
abnormalities.
Developmental
Toxicity
-
Human
-
female
-
Unreported
Specific
Developmental
Abnormalities:
Gastrointestinal
system.
Developmental
Toxicity
-
Human
-
female
-
Unreported
Specific
Developmental
Abnormalities:
Central
nervous
system.
Developmental
Toxicity
-
rat
-
Oral
Effects
on
Embryo
or
Fetus:
Fetotoxicity
(except
death,
e.g.,
stunted
fetus).
Specific
Developmental
Abnormalities:
Blood
and
lymphatic
system
(including
spleen
and
marrow).
Developmental
Toxicity
-
rat
-
Oral
Specific
Developmental
Abnormalities:
Musculoskeletal
system.
Developmental
Toxicity
-
rat
-
Intramuscular
Effects
on
Embryo
or
Fetus:
Cytological
changes
(including
somatic
cell
genetic
material).
Specific
Developmental
Abnormalities:
Central
nervous
system.
Developmental
Toxicity
-
mouse
-
Oral
Specific
Developmental
Abnormalities:
Central
nervous
system.
Specific
target
organ
toxicity
-
single
exposure
no
data
available
Specific
target
organ
toxicity
-
repeated
exposure
no
data
available
Aspiration
hazard
no
data
available
Potential
health
effects
Inhalation
Ingestion
Skin
Eyes
May
be
harmful
if
inhaled.
May
cause
respiratory
tract
irritation.
Toxic
if
swallowed.
May
be
harmful
if
absorbed
through
skin.
May
cause
skin
irritation.
May
cause
eye
irritation.
Signs
and
Symptoms
of
Exposure
can
lead
to
addiction,
Exposure
to
and/or
consumption
of
alcohol
may
increase
toxic
effects.,
respiratory
difficulties,
Constipation.,
Nausea,
Anorexia.,
Vomiting,
Headache,
Drowsiness,
depression,
Skin
disorders,
To
the
best
of
our
knowledge,
the
chemical,
physical,
and
toxicological
properties
have
not
been
thoroughly
investigated.
Additional
Information
RTECS:
CQ6825000
12.
12.1
ECOLOGICAL
INFORMATION
Toxicity
Toxicity
to
fish
Toxicity
to
daphnia
and
other
aquatic
invertebrates
-
P1636
LC50
-
Pimephales
promelas
(fathead
minnow)
-
484
mg/l
-
96
h
EC50
-
Daphnia
magna
(Water
flea)
-
1.465,86
mg/l
-
24
h
12.2
12.3
12.4
12.5
12.6
13.
13.1
14.
14.1
Persistence
and
degradability
no
data
available
Bioaccumulative
potential
no
data
available
Mobility
in
soil
no
data
available
Results
of
PBT
and
vPvB
assessment
no
data
available
Other
adverse
effects
no
data
available
DISPOSAL
CONSIDERATIONS
Waste
treatment
methods
Product
Offer
surplus
and
non-recyclable
solutions
to
a
licensed
disposal
company.
Contact
a
licensed
professional
waste
disposal
service
to
dispose
of
this
material.
Dissolve
or
mix
the
material
with
a
combustible
solvent
and
burn
in
a
chemical
incinerator
equipped
with
an
afterburner
and
scrubber.
Contaminated
packaging
Dispose
of
as
unused
product.
TRANSPORT
INFORMATION
UN
number
14.2
ADR/RID:
2811
UN
proper
shipping
name
IMDG:
2811
IATA:
2811
ADR/RID:
IMDG:
IATA:
TOXIC
SOLID,
ORGANIC,
N.O.S.
(Phenobarbital)
TOXIC
SOLID,
ORGANIC,
N.O.S.
(Phenobarbital)
Toxic
solid,
organic,
n.o.s.
(Phenobarbital)
14.3
Transport
hazard
class(es)
14.4
14.5
14.6
15.
ADR/RID:
6.1
Packaging
group
ADR/RID:
III
Environmental
hazards
ADR/RID:
no
Special
precautions
for
user
no
data
available
REGULATORY
INFORMATION
IMDG:
6.1
IMDG:
III
IMDG
Marine
pollutant:
no
IATA:
6.1
IATA:
III
IATA:
no
This
safety
datasheet
complies
with
the
requirements
of
Regulation
(EC)
No.
1907/2006.
15.1
15.2
16.
Safety,
health
and
environmental
regulations/legislation
specific
for
the
substance
or
mixture
no
data
available
Chemical
Safety
Assessment
no
data
available
OTHER
INFORMATION
Further
information
The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information this document is based on the resent state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Lookchem shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. |
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