2,4,6(1H,3H,5H)-Pyrimidinetrione,5-ethyl-5-phenyl-

1.
1.1
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
Product identifiers
Product name
Product Number
Brand
CAS-No.
:
:
:
:
Phenobarbital
P1636
50-06-6
1.2
Relevant identified uses of the substance or mixture and uses advised against
Identified uses
:
Laboratory chemicals, Manufacture of substances
2.
2.1
2.2
HAZARDS IDENTIFICATION
Classification of the substance or mixture
Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP]
Acute toxicity, Oral (Category 3)
Skin sensitization (Category 1)
Carcinogenicity (Category 2)
Reproductive toxicity (Category 1B)
Classification according to EU Directives 67/548/EEC or 1999/45/EC
May cause harm to the unborn child. Toxic if swallowed. Limited evidence of a carcinogenic effect. May
cause sensitization by skin contact.
Label elements
Labelling according Regulation (EC) No 1272/2008 [CLP]
Pictogram
Signal word
Hazard statement(s)
H301
H317
H351
H360D
Precautionary statement(s)
P201
P280
- P1636
Danger
Toxic if swallowed.
May cause an allergic skin reaction.
Suspected of causing cancer.
May damage the unborn child.
Obtain special instructions before use.
Wear protective gloves.
P301 + P310
P308 + P313
Supplemental Hazard
IF SWALLOWED: Immediately call a POISON CENTER or doctor/
physician.
IF exposed or concerned: Get medical advice/ attention.
none
Statements
Restricted to professional users.
According to European Directive 67/548/EEC as amended.
Hazard symbol(s)
R-phrase(s)
R61
R25
R40
R43
S-phrase(s)
S53
S36/37
S45
May cause harm to the unborn child.
Also toxic if swallowed.
Limited evidence of a carcinogenic effect.
May cause sensitization by skin contact.
Avoid exposure - obtain special instructions before use.
Wear suitable protective clothing and gloves.
In case of accident or if you feel unwell, seek medical advice immediately
(show the label where possible).
Restricted to professional users.
2.3
3.
3.1
Other hazards - none
COMPOSITION/INFORMATION ON INGREDIENTS
Substances
Synonyms
Formula
Molecular Weight
Component
Phenobarbital
:
:
:
5-Ethyl-5-phenyl-2,4,6-pyrimidinetrione
5-Ethyl-5-phenylbarbituric acid
Luminal
C12H12N2O3
232,24 g/mol
Concentration
CAS-No.
EC-No.
50-06-6
200-007-0
-
4.
4.1
4.2
FIRST AID MEASURES
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Take victim immediately to hospital. Consult a physician.
In case of eye contact
Flush eyes with water as a precaution.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
can lead to addiction, Exposure to and/or consumption of alcohol may increase toxic effects., respiratory
difficulties, Constipation., Nausea, Anorexia., Vomiting, Headache, Drowsiness, depression, Skin
- P1636
disorders, To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
4.3
5.
5.1
5.2
5.3
5.4
6.
6.1
6.2
6.3
6.4
7.
7.1
7.2
7.3
8.
8.1
8.2
Indication of any immediate medical attention and special treatment needed
no data available
FIREFIGHTING MEASURES
Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx)
Nature of decomposition products not known.
Carbon oxides, nitrogen oxides (NOx)
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available
ACCIDENTAL RELEASE MEASURES
Personal precautions, protective equipment and emergency procedures
Wear respiratory protection. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate
ventilation. Evacuate personnel to safe areas. Avoid breathing dust.
Environmental precautions
Prevent further leakage or spillage if safe to do so. Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed
containers for disposal.
Reference to other sections
For disposal see section 13.
HANDLING AND STORAGE
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.Avoid exposure - obtain special
instructions before use.
Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire
protection.
Conditions for safe storage, including any incompatibilities
Store in cool place. Keep container tightly closed in a dry and well-ventilated place.
Specific end uses
no data available
EXPOSURE CONTROLS/PERSONAL PROTECTION
Control parameters
Components with workplace control parameters
Exposure controls
Appropriate engineering controls
Avoid contact with skin, eyes and clothing. Wash hands before breaks and immediately after handling
the product.
- P1636
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under
appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique
(without touching glove's outer surface) to avoid skin contact with this product. Dispose of
contaminated gloves after use in accordance with applicable laws and good laboratory practices.
Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and
the standard EN 374 derived from it.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected
according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a full-face particle
respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering
controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use
respirators and components tested and approved under appropriate government standards such
as NIOSH (US) or CEN (EU).
9.
9.1
PHYSICAL AND CHEMICAL PROPERTIES
Information on basic physical and chemical properties
a)
b)
c)
d)
e)
f)
g)
h)
Appearance
Odour
Odour Threshold
pH
Melting point/freezing
point
Initial boiling point and
boiling range
Flash point
Evaporation rate
Form: solid
Colour: white
no data available
no data available
no data available
no data available
no data available
no data available
no data available
i)
Flammability (solid, gas) no data available
j)
k)
l)
Upper/lower
flammability or
explosive limits
Vapour pressure
Vapour density
no data available
no data available
no data available
m) Relative density
no data available
n)
o)
p)
q)
r)
Water solubility
Partition coefficient: n-
octanol/water
Autoignition
temperature
Decomposition
temperature
Viscosity
no data available
no data available
no data available
no data available
no data available
- P1636
s)
t)
Explosive properties
Oxidizing properties
no data available
no data available
9.2
10.
10.1
10.2
10.3
10.4
10.5
10.6
11.
11.1
Other safety information
no data available
STABILITY AND REACTIVITY
Reactivity
no data available
Chemical stability
no data available
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
Strong oxidizing agents
Hazardous decomposition products
Other decomposition products - no data available
TOXICOLOGICAL INFORMATION
Information on toxicological effects
Acute toxicity
LD50 Oral - rat - 162 mg/kg
Skin corrosion/irritation
no data available
Serious eye damage/eye irritation
no data available
Respiratory or skin sensitization
May cause allergic skin reaction.
Germ cell mutagenicity
Genotoxicity in vitro - Hamster - Lungs
Sister chromatid exchange
Genotoxicity in vitro - Hamster - Lungs
Cytogenetic analysis
Genotoxicity in vitro - Human - lymphocyte
Cytogenetic analysis
Genotoxicity in vitro - Human - lymphocyte
Mutation in mammalian somatic cells.
Genotoxicity in vitro - rat - Liver
DNA damage
Genotoxicity in vitro - rat - Liver
Unscheduled DNA synthesis
Genotoxicity in vitro - rat - Liver
DNA inhibition
Genotoxicity in vitro - mouse - Embryo
Morphological transformation.
Genotoxicity in vivo - rat - Oral
Genotoxicity in vivo - rat - Oral
- P1636
Unscheduled DNA synthesis
Genotoxicity in vivo - rat - Intraperitoneal
Genotoxicity in vivo - mouse - Oral
Unscheduled DNA synthesis
Genotoxicity in vivo - mouse - Oral
Cytogenetic analysis
Genotoxicity in vivo - mouse - Oral
Dominant lethal test
Carcinogenicity
Carcinogenicity - mouse - Oral
Tumorigenic:Neoplastic by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. Liver:Tumors.
Carcinogenicity - rat - Oral
Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Liver:Tumors. Endocrine:Thyroid tumors.
Carcinogenicity - rat - Oral
Tumorigenic:Neoplastic by RTECS criteria. Endocrine:Thyroid tumors.
Limited evidence of carcinogenicity in animal studies
IARC:
2B - Group 2B: Possibly carcinogenic to humans (Phenobarbital)
Reproductive toxicity
Presumed human reproductive toxicant May damage the unborn child.
Reproductive toxicity - rabbit - Oral
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of
implants). Effects on Embryo or Fetus: Fetal death. Effects on Fertility: Litter size (e.g.; # fetuses per litter;
measured before birth).
Reproductive toxicity - rabbit - Intramuscular
Effects on Newborn: Biochemical and metabolic.
Reproductive toxicity - rat - Oral
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of
implants). Effects on Fertility: Abortion.
Reproductive toxicity - rat - Oral
Effects on Newborn: Viability index (e.g., # alive at day 4 per # born alive).
Reproductive toxicity - rat - Oral
Effects on Newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4). Effects on
Newborn: Behavioral.
Reproductive toxicity - rat - Subcutaneous
Effects on Fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile
nonpregnant females).
Reproductive toxicity - rat - Subcutaneous
Effects on Newborn: Physical. Effects on Newborn: Delayed effects.
Reproductive toxicity - mouse - Oral
Effects on Fertility: Pre-implantation mortality (e.g., reduction in number of implants per female; total
number of implants per corpora lutea). Effects on Fertility: Post-implantation mortality (e.g., dead and/or
resorbed implants per total number of implants).
Reproductive toxicity - mouse - Oral
Effects on Newborn: Growth statistics (e.g., reduced weight gain). Effects on Newborn: Behavioral.
Reproductive toxicity - mouse - Intraperitoneal
Effects on Fertility: Post-implantation mortality (e.g., dead and/or resorbed implants per total number of
implants).
Reproductive toxicity - mouse - Intraperitoneal
Effects on Newborn: Biochemical and metabolic.
- P1636
Reproductive toxicity - mouse - Parenteral
Maternal Effects: Uterus, cervix, vagina.
Developmental Toxicity - rabbit - Oral
Specific Developmental Abnormalities: Musculoskeletal system. Specific Developmental Abnormalities:
Cardiovascular (circulatory) system.
Developmental Toxicity - rabbit - Oral
Effects on Embryo or Fetus: Cytological changes (including somatic cell genetic material). Effects on
Newborn: Biochemical and metabolic.
Developmental Toxicity - rat - Intraperitoneal
Effects on Embryo or Fetus: Extra embryonic structures (e.g., placenta, umbilical cord). Effects on Embryo
or Fetus: Fetal death. Specific Developmental Abnormalities: Other developmental abnormalities.
Developmental Toxicity - Human - female - Unreported
Specific Developmental Abnormalities: Gastrointestinal system.
Developmental Toxicity - Human - female - Unreported
Specific Developmental Abnormalities: Central nervous system.
Developmental Toxicity - rat - Oral
Effects on Embryo or Fetus: Fetotoxicity (except death, e.g., stunted fetus). Specific Developmental
Abnormalities: Blood and lymphatic system (including spleen and marrow).
Developmental Toxicity - rat - Oral
Specific Developmental Abnormalities: Musculoskeletal system.
Developmental Toxicity - rat - Intramuscular
Effects on Embryo or Fetus: Cytological changes (including somatic cell genetic material). Specific
Developmental Abnormalities: Central nervous system.
Developmental Toxicity - mouse - Oral
Specific Developmental Abnormalities: Central nervous system.
Specific target organ toxicity - single exposure
no data available
Specific target organ toxicity - repeated exposure
no data available
Aspiration hazard
no data available
Potential health effects
Inhalation
Ingestion
Skin
Eyes
May be harmful if inhaled. May cause respiratory tract irritation.
Toxic if swallowed.
May be harmful if absorbed through skin. May cause skin irritation.
May cause eye irritation.
Signs and Symptoms of Exposure
can lead to addiction, Exposure to and/or consumption of alcohol may increase toxic effects., respiratory
difficulties, Constipation., Nausea, Anorexia., Vomiting, Headache, Drowsiness, depression, Skin
disorders, To the best of our knowledge, the chemical, physical, and toxicological properties have not been
thoroughly investigated.
Additional Information
RTECS: CQ6825000
12.
12.1
ECOLOGICAL INFORMATION
Toxicity
Toxicity to fish
Toxicity to daphnia and
other aquatic
invertebrates
- P1636
LC50 - Pimephales promelas (fathead minnow) - 484 mg/l - 96 h
EC50 - Daphnia magna (Water flea) - 1.465,86 mg/l - 24 h
12.2
12.3
12.4
12.5
12.6
13.
13.1
14.
14.1
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
no data available
Other adverse effects
no data available
DISPOSAL CONSIDERATIONS
Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed
professional waste disposal service to dispose of this material. Dissolve or mix the material with a
combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging
Dispose of as unused product.
TRANSPORT INFORMATION
UN number
14.2
ADR/RID: 2811
UN proper shipping name
IMDG: 2811
IATA: 2811
ADR/RID:
IMDG:
IATA:
TOXIC SOLID, ORGANIC, N.O.S. (Phenobarbital)
TOXIC SOLID, ORGANIC, N.O.S. (Phenobarbital)
Toxic solid, organic, n.o.s. (Phenobarbital)
14.3
Transport hazard class(es)
14.4
14.5
14.6
15.
ADR/RID: 6.1
Packaging group
ADR/RID: III
Environmental hazards
ADR/RID: no
Special precautions for user
no data available
REGULATORY INFORMATION
IMDG: 6.1
IMDG: III
IMDG Marine pollutant: no
IATA: 6.1
IATA: III
IATA: no
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1
15.2
16.
Safety, health and environmental regulations/legislation specific for the substance or mixture
no data available
Chemical Safety Assessment
no data available
OTHER INFORMATION
Further information
The above information is believed to be correct but does not purport to be all inclusive and
shall be used only as a guide. The information this document is based on the resent state
of our knowledge and is applicable to the product with regard to appropriate safety precautions.
It does not represent any guarantee of the properties of the product. Lookchem shall not be
held liable for any damage resulting from handling or from contact with the above product.
See reverse side of invoice or packing slip for additional terms and conditions of sale.

- P1636
;

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