• Name

  [1,3]Thiazolo[5,4-b]pyridine

• EINECS
• CAS No. 273-84-7
• Article Data4
• CAS DataBase
• Density 1.369 g/cm³
• Solubility
• Melting Point
• Formula C₆H₄N₂S
• Boiling Point 244.35 °C at 760 mmHg
• Molecular Weight 136.177
• Flash Point 106.324 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms thiazolo(5,4-b)pyridine;thiazolopyridine;THIAZOLO[5,4-B]PYRIDIN;1,3-thiazolino[5,4-b]pyridine;
• PSA 54.02000
• LogP 1.69130

Synthetic route

5470-18-8

2-Chloro-3-nitropyridine

115-08-2

thiocarboxamide

273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions

Conditions	Yield
In sulfolane at 135℃; Microwave irradiation;	26%

857969-93-8

thiazolo[5,4-b]pyridine-2-carboxylic acid

273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions

Conditions	Yield
at 160 - 175℃;

91813-40-0

2-methylthiazolo[5,4-b]pyridine

273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous KMnO4 2: 160 - 175 °C View Scheme

5470-18-8

2-Chloro-3-nitropyridine

273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: sodium disulfide 2: zinc-powder; acetic acid anhydride; acetic acid 3: aqueous KMnO4 4: 160 - 175 °C View Scheme

4282-19-3

3,3’-dinitro-2,2’-dipyridinyl disulfide

273-84-7

[1,3]thiazolo[5,4-b]pyridine

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: zinc-powder; acetic acid anhydride; acetic acid 2: aqueous KMnO4 3: 160 - 175 °C View Scheme

273-84-7

[1,3]thiazolo[5,4-b]pyridine

N-(((E)-2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

1402598-55-3

N-((2-chlorophenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions

Conditions	Yield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.166667h; Stage #2: N-(((E)-2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;	15%

273-84-7

[1,3]thiazolo[5,4-b]pyridine

38240-21-0

2-mercapto-3-amino pyridine

Conditions

Conditions	Yield
With hydrazine hydrate Ambient temperature;

273-84-7

[1,3]thiazolo[5,4-b]pyridine

864867-07-2

1-(2-chlorophenyl)-4-iodo-5-methyl-1H-[1,2,3]triazole

4-(thiazolo[5,4-b]pyridine-2-yl)-1-(2-chlorophenyl)-5-methyl-1H-[1,2,3]triazole

Conditions

Conditions	Yield
With sodium acetate; trans-di-µ-acetatebis[2-(di-o-tolylphosphino)benzyl]dipalladium (II) In N,N-dimethyl-formamide at 140℃; for 8h;

273-84-7

[1,3]thiazolo[5,4-b]pyridine

1402599-44-3

N-((2-(methylsulfanyl)phenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

1402607-94-6

N-((2-(methylsulfanyl)phenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions

Conditions	Yield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.25h; Stage #2: N-((2-(methylsulfanyl)phenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;

273-84-7

[1,3]thiazolo[5,4-b]pyridine

1402599-45-4

N-((2-methoxyphenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

1402598-52-0

N-((2-methoxyphenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions

Conditions	Yield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.25h; Stage #2: N-((2-methoxyphenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;

273-84-7

[1,3]thiazolo[5,4-b]pyridine

1402599-46-5

N-((2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

1402598-55-3

N-((2-chlorophenyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions

Conditions	Yield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.166667h; Stage #2: N-((2-chlorophenyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 0.166667h;

273-84-7

[1,3]thiazolo[5,4-b]pyridine

1402599-47-6

N-((3-methoxy-2-pyridinyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

1402598-58-6

N-((3-methoxy-2-pyridinyl)([1,3]thiazolo[5,4-b]pyridin-2-yl)methyl)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide

Conditions

Conditions	Yield
Stage #1: [1,3]thiazolo[5,4-b]pyridine With n-butyllithium In tetrahydrofuran; toluene at -78℃; for 0.25h; Stage #2: N-((3-methoxy-2-pyridinyl)methylidene)-3,4-dihydro-2H-1,5-benzodioxepine-7-sulfonamide In tetrahydrofuran; toluene for 6h;

[1,3]Thiazolo[5,4-b]pyridine Specification