1-(2,3-Dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazine hydrochloride

The systematic name of Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl-, hydrochloride (1:1) is 4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-ium chloride. With the CAS registry number 70918-74-0, it is also named as (2,3-Dihydro-benzo[1,4]dioxin-2-yl)piperazine-1-yl-methanone hydrochloride. The product's categories are Piperidines, Piperidones, Piperazines; Intermediate of Doxazosin); Intermediate of Doxazocin Mesylate.  

The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.52; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1; (4)ACD/LogD (pH 7.4): 0.37; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1.03; (7)ACD/KOC (pH 5.5): 1.38; (8)ACD/KOC (pH 7.4): 32.2; (9)#H bond acceptors: 5; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 1; (12)Polar Surface Area: 38.77 Å²; (13)Flash Point: 218.2 °C; (14)Enthalpy of Vaporization: 69.38 kJ/mol; (15)Boiling Point: 437.2 °C at 760 mmHg; (16)Vapour Pressure: 7.62E-08 mmHg at 25°C.

Preparation of Methanone,(2,3-dihydro-1,4-benzodioxin-2-yl)-1-piperazinyl-, hydrochloride (1:1): It can be obtained by piperazine and 2,3-dihydro-benzo[1,4]dioxine-2-carbonyl chloride. This reaction needs reagent aq. HCl and solvent ethyl acetate and methanol. The reaction time is 0.5 hours. The yield is 68%.

When you are using this chemical, please be cautious about it as the following:
It is toxic by inhalation, in contact with skin and if swallowed. It also has danger of serious damage to health by prolonged exposure if swallowed. What's more, this chemical is toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) Avoid release to the environment. Refer to special instructions / safety data sheets.

People can use the following data to convert to the molecule structure. 
1. SMILES:[Cl-].O=C(N1CC[NH2+]CC1)C2Oc3c(OC2)cccc3
2. InChI:InChI=1/C13H16N2O3.ClH/c16-13(15-7-5-14-6-8-15)12-9-17-10-3-1-2-4-11(10)18-12;/h1-4,12,14H,5-9H2;1H
3. InChIKey:TUKBWYXLYINULI-UHFFFAOYAD