2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; |
2,2,2,trifluoroethylhydrazine
acetoacetic acid methyl ester
3-methyl-1-(2,2,2-trifluoroethyl)-5-pyrazolone
Conditions | Yield |
---|---|
In ethanol at 20 - 60℃; | 99% |
4-chloro-N-dimethylaminomethylene-2-thiophene carboxamide
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With acetic acid In water at 90℃; for 0.75h; | 99% |
2,2,2,trifluoroethylhydrazine
acetylacetone
3,5-dimethyl-1-(2,2,2-trifluoroethyl)-1H-pyrazole
Conditions | Yield |
---|---|
In ethanol Reflux; | 99% |
With hydrogenchloride In water at 60℃; for 1.5h; | 36 g |
2,2,2,trifluoroethylhydrazine
N-(4-bromobenzylidene)glycine methyl ester
Conditions | Yield |
---|---|
Stage #1: N-(4-bromobenzylidene)glycine methyl ester With silver(I) acetate; caesium carbonate In acetonitrile at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In acetonitrile at 20℃; for 48h; Schlenk technique; | 99% |
2,2,2,trifluoroethylhydrazine
methyl N-(4-chlorobenzylidene)glycinate
Conditions | Yield |
---|---|
Stage #1: methyl N-(4-chlorobenzylidene)glycinate With silver(I) acetate; caesium carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 36h; Schlenk technique; | 97% |
(4-fluorobenzylideneamino)acetic acid methyl ester
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
Stage #1: (4-fluorobenzylideneamino)acetic acid methyl ester With caesium carbonate; silver carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 2h; Schlenk technique; | 96% |
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
Stage #1: methyl 2-(1-naphthalenemethyleneamino)acetate With silver fluoride; caesium carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 30h; Schlenk technique; | 96% |
2,2,2,trifluoroethylhydrazine
methyl 2-((naphthalen-2-yl)methyleneamino)-acetate
Conditions | Yield |
---|---|
Stage #1: methyl 2-((naphthalen-2-yl)methyleneamino)-acetate With silver(I) acetate; caesium carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 24h; Schlenk technique; | 95% |
(3E)-1-benzoyl-3-(dimethylamino)methylidenepyrrolidin-2-one
2,2,2,trifluoroethylhydrazine
N-{2-[5-hydroxy-1-(2,2,2-trifluoroethyl)-1H-pyrazol-4-yl]ethyl}benzamide
Conditions | Yield |
---|---|
With hydrogenchloride In propan-1-ol for 4h; Heating; | 94% |
2,2,2,trifluoroethylhydrazine
C12H13NO4
Conditions | Yield |
---|---|
Stage #1: C12H13NO4 With silver(I) acetate; caesium carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 24h; Schlenk technique; | 93% |
4-(3-Bromo-thiophene-2-carbonyl)-piperidine-1-carboxylic acid tert-butyl ester
2,2,2,trifluoroethylhydrazine
4-{(3-bromo-thiophen-2-yl)-[(2,2,2-trifluoro-ethyl)-hydrazono]-methyl}-piperidine-1-carboxylic acid tert-butyl ester
Conditions | Yield |
---|---|
In butan-1-ol at 110℃; | 92% |
Conditions | Yield |
---|---|
In isopropyl alcohol at 160℃; for 2.5h; Microwave irradiation; | 92% |
Conditions | Yield |
---|---|
In ethanol for 18h; Heating; | 91% |
Conditions | Yield |
---|---|
In isopropyl alcohol at 140℃; for 2h; Microwave irradiation; regioselective reaction; | A 90% B n/a |
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With acetic acid In chloroform at 20℃; for 4h; | 89% |
2,2,2,trifluoroethylhydrazine
methyl 2-((anthracen-9-yl)methyleneamino)-acetate
Conditions | Yield |
---|---|
Stage #1: methyl 2-((anthracen-9-yl)methyleneamino)-acetate With silver(I) acetate; caesium carbonate In acetonitrile at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In acetonitrile at 20℃; for 48h; Schlenk technique; | 88% |
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
Stage #1: 2,2,2,trifluoroethylhydrazine With triethylamine In ethanol at 20℃; for 0.166667h; Stage #2: 2-[(4-bromophenyl)methoxymethylene]propanedinitrile In ethanol at 95℃; for 16h; | 87% |
2,2,2,trifluoroethylhydrazine
2-amino-3-benzyloxycarbonyl-4-oxo-2-pentenoic acid ethyl ester
C17H17F3N2O4
Conditions | Yield |
---|---|
In dichloromethane at 0 - 20℃; for 15h; regioselective reaction; | 86% |
ethyl 4-(2-iodoethoxy)-3-oxobutanoate
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With sodium acetate In acetic acid at 110℃; for 12h; | 86% |
2,2,2,trifluoroethylhydrazine
glycine methyl ester (4-iodobenzaldehyde)imine
Conditions | Yield |
---|---|
Stage #1: glycine methyl ester (4-iodobenzaldehyde)imine With silver(I) acetate; caesium carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 48h; Schlenk technique; | 86% |
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With hydrogenchloride; tricarbonyl(cycloheptatriene)molybdenum(0) In tetrahydrofuran; water at 70℃; for 16h; Sealed tube; | 86% |
tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate
2,2,2,trifluoroethylhydrazine
13-cyclohexyl-6-[4-(ethoxycarbonyl)-1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]-3-methoxy-7H-indolo[2,1-a] [2]benzazepine-10-carboxylic acid 1,1-dimethylethyl ester
Conditions | Yield |
---|---|
With triethylamine In ethanol at 160℃; for 2h; Microwave irradiation; | 84% |
tert-butyl 13-cyclohexyl-6-((2E,Z)-3-(dimethylamino)-2-(ethoxycarbonyl)-2-propenoyl)-3-methoxy-7H-indolo[2,1-a][2]benzazepine-10-carboxylate
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With triethylamine In ethanol at 160℃; for 2h; Microwave irradiation; | 84% |
Conditions | Yield |
---|---|
With sodium acetate In acetic acid at 110℃; for 12h; | 84% |
2,2,2,trifluoroethylhydrazine
(E/Z)-2-(3-chloropyridine-2-carbonyl)-3-dimethylaminoacrylic acid ethyl ester
5-(3-chloropyridin-2-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazole-4-carboxylic acid ethyl ester
Conditions | Yield |
---|---|
In ethanol for 2h; Reflux; | 83% |
In ethanol for 2h; Reflux; | 83% |
2,2,2,trifluoroethylhydrazine
ethyl 2-(4-nitrobenzyl)-3-oxohexanoate
4-(4-Nitro-benzyl)-5-propyl-2-(2,2,2-trifluoro-ethyl)-2H-pyrazol-3-ol
Conditions | Yield |
---|---|
In ethanol for 3h; Heating; | 82% |
2,2,2,trifluoroethylhydrazine
ethyl 4-[1-(dimethylamino)-3-ethoxy-3-oxoprop-1-en-2-yl]-2-[(dimethylamino)methylideneamino]thiazole-5-carboxylate
ethyl 2-amino-4-oxo-5-(2,2,2-trifluoroethylamino)-4,5-dihydrothiazolo[5,4-c]pyridine-7-carboxylate
Conditions | Yield |
---|---|
With hydrogenchloride In ethanol; water for 2h; Reflux; | 82% |
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
Stage #1: [(4-methyl-benzylidene)-amino]-acetic acid methyl ester With silver fluoride; sodium hydroxide In diethyl ether at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In diethyl ether at 20℃; for 12h; Schlenk technique; | 82% |
2,2,2,trifluoroethylhydrazine
glycine methyl ester (4-trifluoromethylbenzaldehyde)imine
Conditions | Yield |
---|---|
Stage #1: glycine methyl ester (4-trifluoromethylbenzaldehyde)imine With silver(I) acetate; caesium carbonate In tetrahydrofuran at 20℃; for 0.05h; Schlenk technique; Stage #2: 2,2,2,trifluoroethylhydrazine In tetrahydrofuran at 20℃; for 1h; Schlenk technique; | 82% |
ethyl 3-{(1R,2R)-2-[(benzyloxy)methyl]-4,4-difluorocyclohexyl}-2-[4-(methylthio)phenyl]-3-oxopropanoate
2,2,2,trifluoroethylhydrazine
Conditions | Yield |
---|---|
With magnesium sulfate In water; 1,1,2,2-tetrachloroethane at 120℃; for 72h; Inert atmosphere; | 81% |
With magnesium sulfate In 1,1,2,2-tetrachloroethane at 120℃; for 72h; |
IUPAC Name: 2,2,2-Trifluoroethylhydrazine
Molecular Formula: C2H5F3N2
Molecular Weight: 114.07 g/mol
Canonical SMILES: C(C(F)(F)F)NN
InChI: InChI=1S/C2H5F3N2/c3-2(4,5)1-7-6/h7H,1,6H2
EINECS: 225-734-0
Product Categories: Aliphatics; Hydrazines; Nitrogen Compounds; Organic Building Blocks
Storage temperature: Flammables area
XLogP3-AA: 0.2
H-Bond Donor: 2
H-Bond Acceptor: 5
Surface Tension: 20.4 dyne/cm
Density: 1.261 g/cm3
Flash Point: 42.8 °C
Enthalpy of Vaporization: 32.36 kJ/mol
Boiling Point: 83.1 °C at 760 mmHg
Vapour Pressure of 2,2,2-Trifluoroethylhydrazine (CAS NO.5042-30-8): 76.5 mmHg at 25 °C
Hazard Codes: Xn
Risk Statements: 10-20/21/22
R10: Flammable.
R20/21/22: Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 36
S36: Wear suitable protective clothing.
RIDADR: UN 1993 3/PG 3
Hazard Note: Harmful
HazardClass: 3.2
PackingGroup of 2,2,2-Trifluoroethylhydrazine (CAS NO.5042-30-8): III
2,2,2-Trifluoroethylhydrazine (CAS NO.5042-30-8), its Synonyms are 2,2,2-Trifluoroethylhydrazine,aqueoussolution ; 2,2,2-Trifluoroethylhydrazine, 70 wt% aqueous solution ; 2,2,2-trifluoroethylhydrazine solution ; Trifluoroethylhydrazine ; 2,2,2-Trifluoroethylhydrazine, 70% aqueous solution . It is clear yellow to green liquid.
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