2,3,4-Trimethoxybenzoic acid supplier

Name
2,3,4-Trimethoxybenzoic acid
EINECS 209-350-0
CAS No. 573-11-5
Article Data30
CAS DataBase
Density 1.219 g/cm³
Solubility
Melting Point 99-102 °C(lit.)
Formula C₁₀H₁₂O₅
Boiling Point 321 °C at 760 mmHg
Molecular Weight 212.202
Flash Point 123.5 °C
Transport Information
Appearance off-white crystalline powder
Safety 24/25
Risk Codes 36/37/38
Molecular Structure
Hazard Symbols
Synonyms Benzoic acid, 2,3,4-trimethoxy-;
PSA 64.99000
LogP 1.41060

Synthetic route

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With dihydrogen peroxide; potassium hydroxide In methanol; water for 8.5h; Reflux;	95%
With tert.-butylhydroperoxide; copper(l) chloride In acetonitrile at 20℃; for 2h;	91%
With permanganate(VII) ion
With potassium hydroxide; dihydrogen peroxide In methanol; water Heating;

: 1178514-38-9
C12H16O6

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With niobium pentachloride In acetonitrile at 0 - 20℃; for 1h;	93%

: 141-82-2
malonic acid

: 634-36-6
1,2,3-trimethoxybenzene

A: 573-11-5
2,3,4-Trimethoxy-benzoic acid

B: 2103-57-3
2,3,4-trimethoxybenzaldehyde

Conditions

Conditions	Yield
With manganese triacetate In acetic acid for 0.0166667h; Heating; Yields of byproduct given;	A 9% B n/a

...Expand

: 634-36-6
1,2,3-trimethoxybenzene

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With n-dodecyllithium; Petroleum ether anschliessend Behandeln mit festem Kohlendioxid unter Zusatz von Aether;
Multi-step reaction with 2 steps 1: hydrogen chloride; benzene; aluminium chloride / 0 - 40 °C / und nachfolgenden Zersetzen mit Eis 2: permanganate View Scheme
Multi-step reaction with 2 steps 1: aluminium chloride; carbon disulfide 2: alcoholic KOH-solution View Scheme
Multi-step reaction with 2 steps 1: AlCl3 / diethyl ether 2: aq. KOH / Heating View Scheme

: 13909-73-4
2',3',4'-trimethoxyacetophenone

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With sodium hypochlorite

: 6395-18-2
methyl 2,3,4-trimethoxybenzoate

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With potassium carbonate

: 4082-16-0
2',3',4'-trimethoxychalcone

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With permanganate(VII) ion; acetone

: 43020-38-8
2,3,4-trimethoxybenzonitrile

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 105339-22-8
(2,3,4-trimethoxy-phenyl)-glyoxylic acid methyl ester

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide Behandeln der Reaktionsloesung mit wss. H2O2;

: 2,2,2-trichloro-1-(2,3,4-trimethoxy-phenyl)-ethanone

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide

: 67-56-1
methanol

: 610-02-6
2,3,4-trihydroxybenzoic acid

: 77-78-1
dimethyl sulfate

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide

...Expand

: 5653-46-3
2-hydroxy-3,4-dimethoxybenzoic acid

: 77-78-1
dimethyl sulfate

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With sodium hydroxide die Loesung unter Zusatz von Aetznatron bezw. konz. Natronlauge kochen;
With sodium hydroxide

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

A: 19676-64-3
2,3,4-trimethoxyphenol

B: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With chloroform; ozone Erhitzen der Reaktionsprodukte mit Wasser, Zink und geringen Mengen Silbernitrat;

: 92288-79-4
(2,3,4-trimethoxy-phenyl)-glyoxylonitrile

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
With potassium hydroxide Heating;

: 67-66-3
chloroform

: 10028-15-6
ozone

: 2103-57-3
2,3,4-trimethoxybenzaldehyde

A: 19676-64-3
2,3,4-trimethoxyphenol

B: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
at 0℃; Erhitzen des Reaktionsprodukts mit Wasser,Zink-Pulver und wenig AgNO3;

...Expand

: 4082-16-0
2',3',4'-trimethoxychalcone

: 67-64-1
acetone

potassium permanganate: potassium permanganate

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

...Expand

: 7664-93-9
sulfuric acid

: 103988-63-2
(2,3,4-trimethoxy-phenyl)-glyoxylic acid

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
Verduennen mit Wasser;

: 634-36-6
1,2,3-trimethoxybenzene

: 1825-40-7
n-dodecyllithium

petroleum ether: petroleum ether

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
folgende Behandlung mit festem CO2;

...Expand

: 6395-23-9
methyl 2-hydroxy-3,4-dimethoxy-benzoate

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: diluted alkaline solution 2: NaOH-solution / die Loesung unter Zusatz von Aetznatron bezw. konz. Natronlauge kochen View Scheme

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 74-88-4
methyl iodide

: 6395-18-2
methyl 2,3,4-trimethoxybenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 50℃; for 5h;	99%

: 496-15-1
1-indoline

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: indolin-1-yl(2,3,4-trimethoxyphenyl)methanone

Conditions

Conditions	Yield
Stage #1: 2,3,4-Trimethoxy-benzoic acid With thionyl chloride; N,N-dimethyl-formamide In toluene at 0 - 20℃; for 4h; Inert atmosphere; Stage #2: 1-indoline With triethylamine In dichloromethane at 20℃; for 14h; Inert atmosphere;	99%

: 150-19-6
O-methylresorcine

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 3-methoxyphenyl 2,3,4-trimethoxybenzoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h;	98%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 5653-46-3
2-hydroxy-3,4-dimethoxybenzoic acid

Conditions

Conditions	Yield
With boron trichloride In n-heptane; dichloromethane at -78 - 20℃; for 3h; Inert atmosphere;	96.4%
With boron tribromide In dichloromethane at -20℃; for 0.5h;	62.2%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 124-68-5
2-Amino-2-methyl-1-propanol

: 85010-19-1
4,4-dimethyl-2-(2,3,4-trimethoxyphenyl)-4,5-oxazoline

Conditions

Conditions	Yield
Stage #1: 2,3,4-Trimethoxy-benzoic acid With oxalyl dichloride; N,N-dimethyl-formamide In dichloromethane at 20℃; for 4h; Chlorination; Stage #2: 2-Amino-2-methyl-1-propanol With thionyl chloride In dichloromethane at 20℃; for 12h; Cyclization;	96%

: 106-38-7
para-bromotoluene

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: C16H18O5S

Conditions

Conditions	Yield
With palladium diacetate; caesium carbonate; sodium sulfate In N,N-dimethyl-formamide at 150℃; for 12h; Inert atmosphere;	95%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 7169-07-5
3,4,5-(trimethoxy)benzoyl chloride

Conditions

Conditions	Yield
With oxalyl dichloride; N,N-dimethyl-formamide In toluene for 3.5h;	94%
With thionyl chloride; sodium hydroxide In water; benzene for 2h; Reflux;	85%
With phosphorus pentachloride

: 2033-89-8
3,4-dimethoxyphenol

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 3,4-dimethoxyphenyl 2,3,4-trimethoxybenzoate

Conditions

Conditions	Yield
With dmap; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 18h;	93%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 123-62-6
propionic acid anhydride

: 2,3,4-trimethoxy-6-propionylbenzoic acid

Conditions

Conditions	Yield
With potassium fluoride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; 1,3,5-trimethyl-benzene at 145℃; for 16h; Inert atmosphere; Glovebox;	92%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 926251-22-1
5-(chlorosulfonyl)-2,3,4-trimethoxybenzoic acid

Conditions

Conditions	Yield
With chlorosulfonic acid at 20℃; for 4h;	91%
With chlorosulfonic acid In dichloromethane at 75℃; for 8h; Cooling with ice;

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 118-93-4
o-hydroxyacetophenone

: 1563185-99-8
C18H18O6

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h; Inert atmosphere;	89%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: C15H29N3O5

: 4-(2,3-bis(tert-butoxycarbonyl)guanidino)butyl 2,3,4-trimethoxybenzoate

Conditions

Conditions	Yield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃;	89%

: 109-65-9
1-bromo-butane

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 139214-91-8
butyl 2,3,4-trimethoxybenzoate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 12h;	87%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 153165-85-6
1R-(1β,4α,5β,6β) 4-amino-5,6-bis(phenylmethoxy)-2-cyclohexen-1-ol

: 153165-93-6
<1R-(1α,4β,5β,6β)> N-<5,6-bis(phenylmethoxy)-4-hydroxy-2-cyclohexen-1-yl>-2,3,4-tris-(methoxy)-benzamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran for 4h; Ambient temperature;	86%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 111798-15-3
2,3,4-trimethoxybenzoic anhydride

Conditions

Conditions	Yield
With methanesulfonyl chloride; triethylamine In tetrahydrofuran at 0℃; for 1h;	85%
With pyridine; thionyl chloride; diethyl ether

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 4083-64-1
Tosyl isocyanate

: N-Ts-2,3,4-trimethoxybenzamide

Conditions

Conditions	Yield
With triethylamine In tetrahydrofuran at 60℃;	85%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 3934-81-4
2,3-dihydroxy-4-methoxybenzoic acid

Conditions

Conditions	Yield
With boron trichloride In dichloromethane at 0 - 20℃; for 11h; Inert atmosphere;	83%
With boron trichloride In dichloromethane at 0 - 20℃; for 14.17h;	76%
With boron trichloride In dichloromethane Ambient temperature;	74%
Stage #1: 2,3,4-Trimethoxy-benzoic acid With hydrogen iodide; acetic acid at 20 - 80℃; for 10h; Stage #2: With sodium hydroxide In water at 20℃; for 1h; pH=1.5;	73%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 153221-51-3
1S-(1α,4α,5β,6β) 4-amino-5,6-bis(phenylmethoxy)-2-cyclohexen-1-ol

: 153221-61-5
<1R-(1α,4α,5β,6β)> N-<5,6-bis(phenylmethoxy)-4-hydroxy-2-cyclohexen-1-yl>-2,3,4-tris-(methoxy)-benzamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran for 4h; Ambient temperature;	82%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 392660-78-5
4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butan-1-amine

: 1353004-52-0
2,3,4-trimethoxy-N-(4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butyl)benzamide

Conditions

Conditions	Yield
Stage #1: 2,3,4-Trimethoxy-benzoic acid With dicyclohexyl-carbodiimide In tetrahydrofuran at 20℃; for 0.0833333h; Stage #2: 4-(7-nitro-3,4-dihydroisoquinoline-2(1H)-yl)butan-1-amine In tetrahydrofuran at 20℃;	82%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 174518-80-0
1,5-diiodo-2,3,4-trimethoxybenzene

Conditions

Conditions	Yield
With [bis(acetoxy)iodo]benzene; lithium iodide In 1,1,1,3,3,3-hexafluoroisopropanol at 20℃; Hunsdiecker type reaction;	81%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 103-71-9
phenyl isocyanate

: 101569-30-6
4,5,6-trimethoxy-2-phenylisoindoline-1,3-dione

Conditions

Conditions	Yield
With dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; sodium acetate In 1,4-dioxane at 100℃; for 36h; Inert atmosphere;	81%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 2292-40-2
3,3',4,4',5,5'-hexamethoxybiphenyl-2,2'-dicarboxylic acid

Conditions

Conditions	Yield
With manganese(IV) oxide; di-μ-chlorobis(norbornadiene)dirhodium(I) In water at 150℃; for 24h; Sealed tube; regiospecific reaction;	81%
With rhodium(III) chloride trihydrate; tetrabutylammonium acetate In N,N-dimethyl-formamide at 80℃; for 20h; Electrolysis;

: 553-53-7
Nicotinic acid hydrazide

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 3-[5-(2,3,4-trimethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-pyridine

Conditions

Conditions	Yield
With trichlorophosphate for 0.25h; microwave irradiation;	79%

: 7466-54-8
2-methoxybenzoylhydrazine

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 2-(2-methoxy-phenyl)-5-(2,3,4-trimethoxy-phenyl)-[1,3,4]oxadiazole

Conditions

Conditions	Yield
With trichlorophosphate for 0.25h; microwave irradiation;	76%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 109-89-7
diethylamine

: 1224865-54-6
2-(diethylamino)-3,4-dimethoxybenzoic acid

Conditions

Conditions	Yield
Stage #1: diethylamine With n-butyllithium In hexane at -30 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,3,4-Trimethoxy-benzoic acid In tetrahydrofuran; hexane at -30 - 0℃; for 4h; Inert atmosphere; Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexane at 0℃; pH=7; Inert atmosphere;	76%
Stage #1: diethylamine With n-butyllithium In tetrahydrofuran; hexane at -30 - 0℃; for 0.5h; Inert atmosphere; Stage #2: 2,3,4-Trimethoxy-benzoic acid In tetrahydrofuran; hexane at -30 - 0℃; for 4h; Stage #3: With hydrogenchloride In water pH=7;	76%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 61948-84-3
2,3,4-trimethoxy-6-nitrobenzoic acid

Conditions

Conditions	Yield
With nitric acid at 0℃; for 0.166667h;	75%
With nitric acid at 0℃; for 0.166667h;	69%
With nitric acid In water at 0℃; for 1.16667h;	69%

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 74-88-4
methyl iodide

: 603-79-2
2,3-dimethylbenzoic acid

: C21H24O7

Conditions

Conditions	Yield
Stage #1: 2,3,4-Trimethoxy-benzoic acid; 2,3-dimethylbenzoic acid With manganese(IV) oxide; di-μ-chlorobis(norbornadiene)dirhodium(I) In water at 150℃; for 24h; Sealed tube; Stage #2: methyl iodide With potassium carbonate In water; acetone at 60℃; for 24h; regiospecific reaction;	75%

...Expand

: 573-11-5
2,3,4-Trimethoxy-benzoic acid

: 153165-86-7
1R-(1β,4α,5β,6β) 4-amino-5,6-bis<(4-methoxyphenyl)methoxy>-2-cyclohexen-1-ol

: <1R-(1α,4β,5β,6β)> N-<5,6-bis-<(4-methoxyphenyl)methoxy>-4-hydroxy-2-cyclohexen-1-yl>-2,3,4-tris-(methoxy)-benzamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In tetrahydrofuran for 4h; Ambient temperature;	72%

2,3,4-Trimethoxybenzoic acid Chemical Properties

Molecular Formula: C₁₀H₁₂O₅
Molar mass: 212.2 g/mol
EINECS: 209-350-0
Density: 1.219 g/cm³
Flash Point: 123.5 °C
Index of Refraction: 1.523
Boiling Point: 321 °C at 760 mmHg
Vapour Pressure: 0.000127 mmHg at 25°C
Melting point: 99-102 °C(lit.)
Appearance: White or almost white crystalline powder
Product categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Fine Chemical & Intermediates;Organic and Carboxylic Acids
Structure of 2,3,4-Trimethoxybenzoic acid (CAS NO.573-11-5):

XLogP3-AA: 1.7
H-Bond Donor: 1
H-Bond Acceptor: 5
IUPAC Name: 2,3,4-Trimethoxybenzoic acid
Canonical SMILES: COC1=C(C(=C(C=C1)C(=O)O)OC)OC
InChI: InChI=1S/C10H12O5/c1-13-7-5-4-6(10(11)12)8(14-2)9(7)15-3/h4-5H,1-3H3,(H,
11,12)
InChIKey: HZNQSWJZTWOTKM-UHFFFAOYSA-N

2,3,4-Trimethoxybenzoic acid Uses

2,3,4-Trimethoxybenzoic acid (CAS NO.573-11-5) can be used as intermediate in organic synthesis.

2,3,4-Trimethoxybenzoic acid Safety Profile

Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
WGK Germany: 3

2,3,4-Trimethoxybenzoic acid Specification

2,3,4-Trimethoxybenzoic acid (CAS NO.573-11-5) also can be called Benzoic acid, 2,3,4-trimethoxy- .It is hazardous,so the first aid measures and others should be known.Such as: When on the skin: first,should flush skin with plenty of water immediatelyfor at least 15 minutes while removing contaminated clothing. Secondly,Get shoesmedical aid . Or in the eyes: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids.Then get medical aid soon.While ,it's Inhaled: Remove from exposure and move to fresh air immediately.Give artificial respiration while not breathing. When breathing is difficult, give oxygen. And as soon as to get medical aid. Then you have the ingesting of the product : Wash mouth out with water,and get medical aid immediately.Notes to physician: Treat supportively and symptomatically.
In addition, 2,3,4-Trimethoxybenzoic acid (CAS NO.573-11-5) is not compatible with strong oxidizing agents, and you must not take it with incompatible materials.And also prevent it to broken down into hazardous decomposition products: carbon dioxide, carbon monoxide.

Product Name

2,3,4-Trimethoxybenzoic acid

Synthetic route

2,3,4-Trimethoxybenzoic acid Chemical Properties

2,3,4-Trimethoxybenzoic acid Uses

2,3,4-Trimethoxybenzoic acid Safety Profile

2,3,4-Trimethoxybenzoic acid Specification

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