2,3,5,6-Tetrafluoropyridine

The IUPAC name of 2,3,5,6-Tetrafluoropyridine is 2,3,5,6-tetrafluoropyridine. With the CAS registry number 2875-18-5, it is also named as Pyridine, 2,3,5,6-tetrafluoro-. The product's categories are Pyridine; Heterocyclic Compounds; Fluoropyridines; Halopyridines; C5; Heterocyclic Building Blocks; Pyridines. Besides, it is clear colorless liquid, which should be stored in refrigerator in sealed, cool and dry place. In addition, its molecular formula is C₅HF₄N and molecular weight is 151.06.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.06; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.06; (4)ACD/LogD (pH 7.4): 1.06; (5)ACD/BCF (pH 5.5): 3.79; (6)ACD/BCF (pH 7.4): 3.79; (7)ACD/KOC (pH 5.5): 90.27; (8)ACD/KOC (pH 7.4): 90.27; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 12.89 Å²; (13)Index of Refraction: 1.403; (14)Molar Refractivity: 24.31 cm³; (15)Molar Volume: 99.4 cm³; (16)Polarizability: 9.64×10^-24cm³; (17)Surface Tension: 28.5 dyne/cm; (18)Density: 1.518 g/cm³; (19)Flash Point: 30.6 °C; (20)Enthalpy of Vaporization: 33.06 kJ/mol; (21)Boiling Point: 106 °C at 760 mmHg; (22)Vapour Pressure: 33.6 mmHg at 25 °C.

Preparation of 2,3,5,6-Tetrafluoropyridine: this chemical can be prepared by Pentafluoro-pyridine.



This reaction needs DIBAL and Bis-(2-methoxy-ethyl) ether at temperature of 100 °C. The reaction time is 24 hours. The yield is 77 %.

Uses of 2,3,5,6-Tetrafluoropyridine: it can react with S,S-Diphenyl-sulfimide to get 2-(S,S-Diphenylsulfilimino)-3,5,6-trifluoropyridine.



This reaction needs Tetrahydrofuran by heating for 4 hours. The yield is 95 %.

When you are using this chemical, please be cautious about it as the following: it is flammable. And it is also irritating to eyes, respiratory system and skin. You should wear suitable protective clothing. After contact with skin, please wash immediately with plenty of soap-suds.

People can use the following data to convert to the molecule structure.
(1)SMILES: Fc1c(F)nc(F)c(F)c1
(2)InChI: InChI=1/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H
(3)InChIKey: HWIPMBCMGVXOKN-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C5HF4N/c6-2-1-3(7)5(9)10-4(2)8/h1H
(5)Std. InChIKey: HWIPMBCMGVXOKN-UHFFFAOYSA-N