Product Name

  • Name

    2,4,6-Trifluorobenzonitrile

  • EINECS -0
  • CAS No. 96606-37-0
  • Article Data7
  • CAS DataBase
  • Density 1.37 g/cm3
  • Solubility
  • Melting Point 57-61 °C
  • Formula C7H2F3N
  • Boiling Point 166.5 °C at 760 mmHg
  • Molecular Weight 157.095
  • Flash Point 54.5 °C
  • Transport Information UN 3276
  • Appearance white to light yellow crystal powder
  • Safety 36/37/39-26-36
  • Risk Codes 36/37/38-20/21/22
  • Molecular Structure Molecular Structure of 96606-37-0 (2,4,6-Trifluorobenzonitrile)
  • Hazard Symbols HarmfulXn, ToxicT, IrritantXi
  • Synonyms 2,4,6-Ditrfluorobenzonitrile;
  • PSA 23.79000
  • LogP 1.97558

Synthetic route

C26H17AuF3N2P

C26H17AuF3N2P

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
In 1,4-dioxane at 100℃; for 3h; Kinetics; Inert atmosphere; Schlenk technique; Sealed tube;98%
2,4,6-trifluoro-3,5-dichlorobenzonitrile
31881-89-7

2,4,6-trifluoro-3,5-dichlorobenzonitrile

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
With formic acid; zinc In water at 75℃; Solvent;85%
With hydrogenchloride; acetic acid; zinc In water at 90 - 105℃; for 6h; Reagent/catalyst; Temperature;79.8%
With palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine In ethyl acetate at 90℃; under 3750.38 Torr; for 12h; Solvent; Temperature; Reagent/catalyst; Autoclave;
With palladium 10% on activated carbon; hydrogen; triethylamine In ethyl acetate at 60 - 65℃; under 7500.75 - 9000.9 Torr; for 8h; Solvent; Temperature; Autoclave;
3-chloro-2,4,6-trifluorobenzonitrile

3-chloro-2,4,6-trifluorobenzonitrile

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
With acetic acid; zinc In water at 70℃; for 3h;60%
2,4,6-trifluorobenzamide
82019-50-9

2,4,6-trifluorobenzamide

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
With phosphorus pentoxide at 200 - 250℃; for 1.25h;55%
pentachlorobenzonitrile
20925-85-3

pentachlorobenzonitrile

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: potassium fluoride / sulfolane / 3 h / 130 - 140 °C / Inert atmosphere
2: N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; hydrogen / ethyl acetate / 12 h / 90 °C / 3750.38 Torr / Autoclave
View Scheme
Multi-step reaction with 2 steps
1: 1,3-dimethyl-2-imidazolidinone; potassium fluoride; cetyltrimethylammonium chloride / 3 h / 150 - 160 °C
2: palladium 10% on activated carbon; hydrogen; triethylamine / ethyl acetate / 8 h / 60 - 65 °C / 7500.75 - 9000.9 Torr / Autoclave
View Scheme
Multi-step reaction with 2 steps
1: potassium fluoride; 18-crown-6 ether / sulfolane / 4 h / 125 - 135 °C / Inert atmosphere
2: zinc; hydrogenchloride; acetic acid / water / 6 h / 90 - 105 °C
View Scheme
2,4,6-trifluorophenyl(triphenylphosphine)gold(I)

2,4,6-trifluorophenyl(triphenylphosphine)gold(I)

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Hexafluorobenzene; benzene / 3 h / 80 °C / Inert atmosphere; Schlenk technique; Sealed tube
2: dichloromethane / 4 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
3: 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube
View Scheme
trans-diacetato(2,4,6-trifluorophenyl)(triphenylphosphine)gold(III)

trans-diacetato(2,4,6-trifluorophenyl)(triphenylphosphine)gold(III)

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane / 4 h / 25 °C / Inert atmosphere; Schlenk technique; Sealed tube
2: 1,4-dioxane / 3 h / 100 °C / Inert atmosphere; Schlenk technique; Sealed tube
View Scheme
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)pent-4-yn-1-amine

N-(2-(trimethylsilyl)ethynyl)-N-(p-tosyl)pent-4-yn-1-amine

C24H25F3N2O2SSi
1379786-69-2

C24H25F3N2O2SSi

Conditions
ConditionsYield
With μ1-carbonyl-η5-cyclopentadienyl-η2-dimethylfumaratecobalt In toluene at 110℃; for 15h; Inert atmosphere; regioselective reaction;100%
4-Octyne
1942-45-6

4-Octyne

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

(Z)-3-(2,4,6-trifluorophenyl)-2-propylhex-2-enenitrile
1453500-99-6

(Z)-3-(2,4,6-trifluorophenyl)-2-propylhex-2-enenitrile

Conditions
ConditionsYield
With bis(1,5-cyclooctadiene)nickel (0); triphenylborane; bis[2-(diphenylphosphino)phenyl] ether at 100℃; for 8h; Inert atmosphere; chemoselective reaction;98%
4-methylphenylthiotrimethylsilane
38325-59-6

4-methylphenylthiotrimethylsilane

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-tris-p-tolylsufanylbenzonitrile

2,4,6-tris-p-tolylsufanylbenzonitrile

Conditions
ConditionsYield
With carbon dioxide; tetrabutylammomium bromide; cesium fluoride at 110℃; under 172517 Torr;95%
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

(2,4,6-trifluorophenyl)methanamine
214759-21-4

(2,4,6-trifluorophenyl)methanamine

Conditions
ConditionsYield
With ammonia; hydrogen In isopropyl alcohol at 65 - 75℃; under 7500.75 Torr; Reagent/catalyst; Temperature;94%
With hydrogen; triethylamine In toluene at 115 - 125℃; under 15001.5 Torr; for 4h; Pressure; Temperature; Solvent; Reagent/catalyst;86.8%
With ammonia; hydrogen In methanol at 90℃; under 7500.75 Torr; for 8h; Temperature; Autoclave;85%
With 5%-palladium/activated carbon; hydrogen; propionic acid at 10 - 15℃; under 9750.98 - 11251.1 Torr; for 5h; Pressure; Temperature; Autoclave;39.3%
With palladium 10% on activated carbon; hydrogen; acetic acid at 90℃; under 7500.75 Torr; for 16h; Reagent/catalyst; Temperature;6 g
(4-tert-butylphenoxy)trimethylsilane
25237-79-0

(4-tert-butylphenoxy)trimethylsilane

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-tris(4-tert-butylphenoxy)benzonitrile
1085323-21-2

2,4,6-tris(4-tert-butylphenoxy)benzonitrile

Conditions
ConditionsYield
With carbon dioxide; tetrabutylammomium bromide; cesium fluoride at 110℃; under 172517 Torr;90%
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

3,6-di-methoxy-9H-carbazole

3,6-di-methoxy-9H-carbazole

C49H38N4O6

C49H38N4O6

Conditions
ConditionsYield
With potassium tert-butylate In dichloromethane; N,N-dimethyl-formamide for 6h; Inert atmosphere;90%
C30H28N2

C30H28N2

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-tris(3-(6-(9H-carbazol-9-yl)hexyl)-9H-carbazol-9-yl)benzonitrile

2,4,6-tris(3-(6-(9H-carbazol-9-yl)hexyl)-9H-carbazol-9-yl)benzonitrile

Conditions
ConditionsYield
Stage #1: C30H28N2 With sodium hydride In N,N-dimethyl-formamide at 25℃; for 3h; Inert atmosphere;
Stage #2: 2,4,6-trifluorobenzonitrile In N,N-dimethyl-formamide at 25℃; for 24h; Inert atmosphere;		90%
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-trifluoro-3,5-di-deuterated benzonitrile

2,4,6-trifluoro-3,5-di-deuterated benzonitrile

Conditions
ConditionsYield
With platinum(IV) oxide; water-d2 at 250℃; for 14h;89%
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2-phenyl-1H-benzoimidazole
716-79-0

2-phenyl-1H-benzoimidazole

2,4,6-tris(2-phenyl-1H-benzo[d]imidazol-1-yl)benzonitrile

2,4,6-tris(2-phenyl-1H-benzo[d]imidazol-1-yl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;88%
With potassium carbonate In dimethyl sulfoxide at 150℃; for 12h; Inert atmosphere;88%
4-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole

4-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

C97H83N7O3

C97H83N7O3

Conditions
ConditionsYield
Stage #1: 4-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole With sodium hydride In tetrahydrofuran for 3.25h; Inert atmosphere;
Stage #2: 2,4,6-trifluorobenzonitrile In tetrahydrofuran at 20℃; for 24h; Inert atmosphere;		88%
Stage #1: 4-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole With sodium hydride In tetrahydrofuran at 20℃; Inert atmosphere;
Stage #2: 2,4,6-trifluorobenzonitrile In tetrahydrofuran for 12h;		64%
3-methoxycarbazole
18992-85-3

3-methoxycarbazole

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-tris(3-methoxy-9H-carbazol-9-yl)benzonitrile

2,4,6-tris(3-methoxy-9H-carbazol-9-yl)benzonitrile

Conditions
ConditionsYield
Stage #1: 3-methoxycarbazole With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2,4,6-trifluorobenzonitrile In tetrahydrofuran at 20℃; for 12h;		88%
3-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole

3-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-tris(3-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazol-9-yl)benzonitrile

2,4,6-tris(3-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazol-9-yl)benzonitrile

Conditions
ConditionsYield
Stage #1: 3-(6-(9H-carbazol-9-yl)hexyloxy)-9H-carbazole With sodium hydride In tetrahydrofuran at 0℃; for 0.5h; Inert atmosphere;
Stage #2: 2,4,6-trifluorobenzonitrile In tetrahydrofuran at 20℃; for 12h;		86%
morpholine
110-91-8

morpholine

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,6-difluoro-4-morpholin-4-yl-benzonitrile
840481-30-3

2,6-difluoro-4-morpholin-4-yl-benzonitrile

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In methanol at 50℃; for 18h;85%
With N-ethyl-N,N-diisopropylamine In methanol at 50℃; for 6h;68%
N'-(3-hydroxyphenyl)-N,N-dimethyl-sulfamide
539807-29-9

N'-(3-hydroxyphenyl)-N,N-dimethyl-sulfamide

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide
1084333-31-2

N'-[3-(2-cyano-3,5-difluorophenoxy)phenyl]-N,N-dimethyl-sulfamide

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran at 20℃; for 48h;84%
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

1-t-Butoxycarbonylpiperazine
57260-71-6

1-t-Butoxycarbonylpiperazine

tert-butyl 4-(4-cyano-2,5-difluorophenyl)piperazine-1-carboxylate

tert-butyl 4-(4-cyano-2,5-difluorophenyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate at 90℃; for 24h; Inert atmosphere;84%
(E)-but-2-enol
504-61-0

(E)-but-2-enol

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2-((E)-but-2-enyloxy)-4,6-difluorobenzonitrile

2-((E)-but-2-enyloxy)-4,6-difluorobenzonitrile

Conditions
ConditionsYield
Stage #1: (E)-but-2-enol With sodium hydride In tetrahydrofuran; mineral oil for 0.166667h; Cooling with ice;
Stage #2: 2,4,6-trifluorobenzonitrile In tetrahydrofuran; mineral oil at 20℃; for 4h; Cooling with ice;		80%
9H-carbazole
86-74-8

9H-carbazole

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-tri(9H-carbazol-9-yl)benzonitrile

2,4,6-tri(9H-carbazol-9-yl)benzonitrile

Conditions
ConditionsYield
With potassium carbonate In dimethyl sulfoxide at 20 - 150℃; for 24h; Inert atmosphere;80%
With potassium tert-butylate In N,N-dimethyl-formamide at 80℃;
1-(triisopropylsilyl)-1H-indole
123191-00-4

1-(triisopropylsilyl)-1H-indole

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

2,4,6-trifluoro-3-(1-(triisopropylsilyl)-1H-indol-3-yl)benzonitrile

2,4,6-trifluoro-3-(1-(triisopropylsilyl)-1H-indol-3-yl)benzonitrile

Conditions
ConditionsYield
With (triphenylphosphine)gold(I) chloride; 1-pivaloyloxy-1,2-benziodoxol-3(1H)-one; silver pivalate; dimethyl sulfoxide In 1,4-dioxane at 110℃; for 16h; Inert atmosphere; regioselective reaction;78%
9-(6-((9H-carbazol-4-yl)oxy)hexyl)-4-((4-vinylbenzyl)oxy)-9H-carbazole

9-(6-((9H-carbazol-4-yl)oxy)hexyl)-4-((4-vinylbenzyl)oxy)-9H-carbazole

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

C124H107N7O6

C124H107N7O6

Conditions
ConditionsYield
Stage #1: 9-(6-((9H-carbazol-4-yl)oxy)hexyl)-4-((4-vinylbenzyl)oxy)-9H-carbazole With sodium hydride In tetrahydrofuran for 0.5h;
Stage #2: 2,4,6-trifluorobenzonitrile In tetrahydrofuran at 60℃; for 24h; Inert atmosphere;		78%
(1,3-dimethylimidazol-2-ylidene)borane
1211417-77-4

(1,3-dimethylimidazol-2-ylidene)borane

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

(2-cyano-3,5-difluorophenyl)(1,3-dimethyl-1H-imidazol-3-ium-2-yl)dihydroborate

(2-cyano-3,5-difluorophenyl)(1,3-dimethyl-1H-imidazol-3-ium-2-yl)dihydroborate

Conditions
ConditionsYield
With [4,4’-bis(1,1-dimethylethyl)-2,2’-bipyridine-N1,N1‘]bis [3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-N]phenyl-C]iridium(III) hexafluorophosphate; sodium acetate; ethyl 2-sulfanylacetate In tetrahydrofuran at 20℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation; regioselective reaction;75%
TEMPOL
45985-24-8, 2226-96-2

TEMPOL

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

C34H53N4O6
1239967-19-1

C34H53N4O6

Conditions
ConditionsYield
Stage #1: TEMPOL With sodium amide In 1,3-dimethyl-2-imidazolidinone at 20℃; for 0.5h; Inert atmosphere;
Stage #2: 2,4,6-trifluorobenzonitrile In 1,3-dimethyl-2-imidazolidinone at 0 - 50℃; Inert atmosphere;		73%
tert-butyl 3-hydroxyphenylcarbamate
19962-06-2

tert-butyl 3-hydroxyphenylcarbamate

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

C18H16F2N2O3
1084333-33-4

C18H16F2N2O3

Conditions
ConditionsYield
With sodium hydride In tetrahydrofuran; mineral oil at 0 - 20℃;70%
With sodium hydride In tetrahydrofuran at 0 - 20℃; for 17h;70%
With sodium hydride In tetrahydrofuran at 0 - 20℃;70%
N-(trifluoromethylsulfonyloxy)pyridinium trifluoromethanesulfonate
93743-67-0

N-(trifluoromethylsulfonyloxy)pyridinium trifluoromethanesulfonate

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

1-(3-cyano-2,4,6-trifluorophenyl)pyridin-1-ium trifluoromethanesulfonate

1-(3-cyano-2,4,6-trifluorophenyl)pyridin-1-ium trifluoromethanesulfonate

Conditions
ConditionsYield
With tris(2,2-bipyridine)ruthenium(II) hexafluorophosphate In acetonitrile for 1.5h; Sealed tube; Schlenk technique; Inert atmosphere; Irradiation;68%
t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate
1073973-04-2

tert-butyl 2-(4-cyano-3,5-difluorophenyl)hydrazinecarboxylate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In dimethyl sulfoxide at 20℃; for 120.16h;61%
diguanidine carbonate
593-85-1

diguanidine carbonate

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

phenol
108-95-2

phenol

5,7-diphenoxy-2,4-quinazolinediamine

5,7-diphenoxy-2,4-quinazolinediamine

Conditions
ConditionsYield
Stage #1: 2,4,6-trifluorobenzonitrile; phenol With potassium carbonate In 1-methyl-pyrrolidin-2-one at 120℃; for 0.166667h; Microwave irradiation;
Stage #2: diguanidine carbonate In 1-methyl-pyrrolidin-2-one at 150℃; for 0.25h; Microwave irradiation;		61%
...Expand
2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

A

2-amino-4,6-difluorobenzonitrile
190011-84-8

2-amino-4,6-difluorobenzonitrile

B

4-amino-2,6-difluorobenzonitrile

4-amino-2,6-difluorobenzonitrile

Conditions
ConditionsYield
With ammonia In ethanol at 35℃; for 18h;A 60%
B 37%
With ammonium hydroxide In water; acetonitrile at 20℃; for 72h;A 47%
B n/a
With ammonia In isopropyl alcohol at 45℃; for 16h;
dimethylbis(η5-pentamethylcyclopentadienyl)uranium
67605-92-9

dimethylbis(η5-pentamethylcyclopentadienyl)uranium

2,4,6-trifluorobenzonitrile
96606-37-0

2,4,6-trifluorobenzonitrile

[(C5(CH3)5)2U(NC(CH3)-2,4,6-F3-C6H2)2]
951238-97-4

[(C5(CH3)5)2U(NC(CH3)-2,4,6-F3-C6H2)2]

Conditions
ConditionsYield
In toluene under N2; soln. of nitrile (2 equiv.) in toluene added to soln. of U complex in toluene; mixt. stirred at room temp. for 12-15 h; volatiles removed (vac.); dissolved in pentane; filtered through Celite;solvent removed (vac.);59%

2,4,6-Trifluorobenzonitrile Specification

The IUPAC name of this chemical is 2,4,6-trifluorobenzonitrile. With the CAS registry number 96606-37-0, it is also named as Benzonitrile, 2,4,6-trifluoro-. The product's categories are Fluorobenzene Series; Aromatic Nitriles; Fluorobenzene; Nitrile; Aromatics Compounds; Aromatics; C6 to C7; Cyanides / Nitriles; Nitrogen Compounds. It is white to light yellow crystal powder which is insoluble in water and stable under normal temperature and pressure. Additionally, this chemical should be sealed in the container and stored in the cool and dry place.

The other characteristics of this product can be summarized as: (1)ACD/LogP: 1.51; (2)# of Rule of 5 Violations: 0; (3)#H bond acceptors: 1; (4)#H bond donors: 0; (5)#Freely Rotating Bonds: 0; (6)Index of Refraction: 1.464; (7)Molar Refractivity: 31.65 cm3; (8)Molar Volume: 114.6 cm3; (9)Polarizability: 12.55×10-24 cm3; (10)Surface Tension: 33.1 dyne/cm; (11)Enthalpy of Vaporization: 40.3 kJ/mol; (12)Vapour Pressure: 1.78 mmHg at 25°C; (13)Exact Mass: 157.013934; (14)MonoIsotopic Mass: 157.013934; (15)Topological Polar Surface Area: 23.8; (16)Heavy Atom Count: 11; (17)Complexity: 173.

Preparation of 2,4,6-Trifluorobenzonitrile: It can be obtained by 2,4,6-trifluorobenzamide. This reaction needs reagent P2O5 at temperature of 200-250 °C. The reaction time is 1.25 hours. The yield is 55%. 

Uses of 2,4,6-Trifluorobenzonitrile: It can produce 2-amino-4,6-difluorobenzonitrileand 4-amino-2,6-difluorobenzonitrile. This reaction needs reagent NH3 and solvent ethanol at temperature of 35 °C. The reaction time is 18 hours. The yield is 60%.

When you are using this chemical, please be cautious about it as the following:
It is not only harmful by inhalation, in contact with skin and if swallowed, but also irritating to eyes, respiratory system and skin. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
1. SMILES:N#Cc1c(F)cc(F)cc1F
2. InChI:InChI=1/C7H2F3N/c8-4-1-6(9)5(3-11)7(10)2-4/h1-2H 
3. InChIKey:HTKFGTCCOJIUIK-UHFFFAOYAE
4. Std. InChI:InChI=1S/C7H2F3N/c8-4-1-6(9)5(3-11)7(10)2-4/h1-2H 
5. Std. InChIKey:HTKFGTCCOJIUIK-UHFFFAOYSA-N

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