2,4-Dichloro-5-methylpyrimidine

The 2,4-Dichloro-5-methylpyrimidine, with the CAS registry number 1780-31-0 and EINECS registry number 217-227-8, is also called 5-Methyl-2,4-dichloropyrimidine. And the molecular formula of this chemical is C₅H₄Cl₂N₂. It is a kind of white to off white low melting solid, and belongs to the following product categories: Halides; Heterocycles; Pharmacetical; Pyrimidine; Building Blocks; Halogenated; Nucleotides and Nucleosides; Pyrimidines; Nucleic acids; Bases & Related Reagents; Nucleotides; Halogenated Heterocycles; Heterocyclic Building Blocks.

The physical properties of 2,4-Dichloro-5-methylpyrimidine are as following: (1)ACD/LogP: 1.62; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 1.62; (4)ACD/LogD (pH 7.4): 1.62; (5)ACD/BCF (pH 5.5): 9.94; (6)ACD/BCF (pH 7.4): 9.94; (7)ACD/KOC (pH 5.5): 180.15; (8)ACD/KOC (pH 7.4): 180.15; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 0; (12)Polar Surface Area: 25.78 Å²; (13)Index of Refraction: 1.551; (14)Molar Refractivity: 37.05 cm³; (15)Molar Volume: 116 cm³; (16)Polarizability: 14.68×10^-24cm³; (17)Surface Tension: 47.6 dyne/cm; (18)Density: 1.404 g/cm³; (19)Flash Point: 118.5 °C; (20)Enthalpy of Vaporization: 45.25 kJ/mol; (21)Boiling Point: 234.9 °C at 760 mmHg; (22)Vapour Pressure: 0.079 mmHg at 25°C.

Uses of 2,4-Dichloro-5-methylpyrimidine: It can react with piperidineto produce 2-chloro-5-methyl-4-piperidin-1-yl-pyrimidine. This reaction will need solvent dioxane. The reaction time is 2 hours with ambient temperature, and the yield is about 83%. 

 
You should be cautious while dealing with this chemical. It may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; Take off immediately all contaminated clothing; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: Cc1cnc(nc1Cl)Cl
(2)InChI: InChI=1/C5H4Cl2N2/c1-3-2-8-5(7)9-4(3)6/h2H,1H3
(3)InChIKey: DQXNTSXKIUZJJS-UHFFFAOYAR