2,4-Difluorobenzyl bromide

The IUPAC name of 2,4-Difluorobenzyl bromide is 1-(bromomethyl)-2,4-difluorobenzene. With the CAS registry number 23915-07-3, it is also named as Benzene,1-(bromomethyl)-2,4-difluoro-. The product's categories are Fluoro-contained Benzyl bromide Series; Aromatic Halides (substituted); Benzene Series; Miscellaneous; Fluorinated Benzene Series. Besides, it is clear yellow liquid, which should be stored in sealed container in cool and dry place. In addition, its molecular formula is C₇H₅BrF₂ and molecular weight is 207.01.

The other characteristics of this product can be summarized as: (1)EINECS: 245-938-3; (2)ACD/LogP: 3.06; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): 3.06; (5)ACD/LogD (pH 7.4): 3.06; (6)ACD/BCF (pH 5.5): 124.63; (7)ACD/BCF (pH 7.4): 124.63; (8)ACD/KOC (pH 5.5): 1100.65; (9)ACD/KOC (pH 7.4): 1100.65; (10)#H bond acceptors: 0; (11)#H bond donors: 0; (12)#Freely Rotating Bonds: 1; (13)Polar Surface Area: 0 Å²; (14)Index of Refraction: 1.522; (15)Molar Refractivity: 38.88 cm³; (16)Molar Volume: 127.3 cm³; (17)Polarizability: 15.41×10^-24cm³; (18)Surface Tension: 35.3 dyne/cm; (19)Density: 1.625 g/cm³; (20)Flash Point: 40 °C; (21)Enthalpy of Vaporization: 40.85 kJ/mol; (22)Boiling Point: 189.7 °C at 760 mmHg; (23)Vapour Pressure: 0.776 mmHg at 25 °C.

Uses of 2,4-Difluorobenzyl bromide: it can react with Acetylamino-malonic acid diethyl ester to get 2-Acetylamino-2-(2,4-difluoro-benzyl)-malonic acid diethyl ester.



This reaction needs NaOEt and Ethanol by heating for 2 hours. The yield is 90 %.

When you are using this chemical, please be cautious about it as the following: it is flammable that may cause burns. Please keep away from sources of ignition. It is also irritating to eyes. Additionally, it may cause sensitization by inhalation and skin contact. Please do not breathe vapour. And you should avoid contact with eyes. Moreover, you should wear suitable protective clothing, gloves and eye/face protection. Furthermore, in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. And in case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)

People can use the following data to convert to the molecule structure.
(1)SMILES: BrCc1ccc(F)cc1F
(2)InChI: InChI=1/C7H5BrF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
(3)InChIKey: IBLMYGXJKQIGSN-UHFFFAOYAQ
(4)Std. InChI: InChI=1S/C7H5BrF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2
(5)Std. InChIKey: IBLMYGXJKQIGSN-UHFFFAOYSA-N