2,4-Difluorobiphenyl

The 2,4-Difluorobiphenyl, with the CAS registry number 37847-52-2, is also known as 2,4-Difluoro-1,1'-biphenyl. It belongs to the product categories of Biphenyl Derivatives; Biphenyl & Diphenyl Ether. Its EINECS registry number is 253-690-2. This chemical's molecular formula is C₁₂H₈F₂ and molecular weight is 190.19. Its systematic name is called 2,4-difluorobiphenyl.

Physical properties of 2,4-Difluorobiphenyl: (1)ACD/LogP: 4.45; (2)ACD/LogD (pH 5.5): 4.45; (3)ACD/LogD (pH 7.4): 4.45; (4)ACD/BCF (pH 5.5): 1425.55; (5)ACD/BCF (pH 7.4): 1425.55; (6)ACD/KOC (pH 5.5): 6298.23; (7)ACD/KOC (pH 7.4): 6298.23; (8)#Freely Rotating Bonds: 1; (9)Index of Refraction: 1.535; (10)Molar Refractivity: 50.83 cm³; (11)Molar Volume: 163.1 cm³; (12)Surface Tension: 34.3 dyne/cm; (13)Density: 1.165 g/cm³; (14)Flash Point: 83 °C; (15)Enthalpy of Vaporization: 46.13 kJ/mol; (16)Boiling Point: 243.7 °C at 760 mmHg; (17)Vapour Pressure: 0.0494 mmHg at 25°C.

Preparation of 2,4-Difluorobiphenyl: this chemical can be prepared by (2,4-difluoro-phenyl)-piperidin-1-yl-diazene and benzene. This reaction will need reagent CF₃COOH. The reaction time is 3 hours with reaction temperature of 65 - 70 °C. The yield is about 36%.

Uses of 2,4-Difluorobiphenyl: it can be used to produce 4-(2',4'-difluoro-biphenyl-4-yl)-4-oxo-butyric acid at temperature of 20 °C. This reaction will need reagent AlCl₃ and solvent 1,2-dichloro-ethane with reaction time of 3 hours. The yield is about 40%.

When you are using this chemical, please be cautious about it as the following:
This chemical may cause inflammation to the skin or other mucous membranes. It is irritating to eyes, respiratory system and skin. When using do not eat, drink or smoke. You must avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: Fc2cc(F)ccc2c1ccccc1
(2)InChI: InChI=1/C12H8F2/c13-10-6-7-11(12(14)8-10)9-4-2-1-3-5-9/h1-8H
(3)InChIKey: JVHAJKHGPDDEEU-UHFFFAOYAJ