• Name

  2,4-Dimethylaniline-6-sulfonic acid

• EINECS 201-811-4
• CAS No. 88-22-2
• Density 1.368 g/cm³
• Solubility 3.049g/L at 25℃
• Melting Point 146-149°C(lit.)
• Formula C₈H₁₁NO₃S
• Boiling Point
• Molecular Weight 201.246
• Flash Point
• Transport Information
• Appearance white to yellowish powder
• Safety 26-36/37/39
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xn
• Synonyms 3,5-Xylenesulfonicacid, 2-amino- (6CI,8CI);1-Amino-2,4-dimethylbenzene-6-sulfonic acid;2-Amino-3,5-dimethylbenzenesulfonic acid;2-Amino-3,5-xylenesulfonic acid;4,6-Dimethylaniline-2-sulfonic acid;C.I. 24855;NSC 7548;
• PSA 88.77000
• LogP 2.79430

Synthetic route

2,4-dimethylanilinium butylamidosulfate

A

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

B

101861-78-3

2,4-dimethyl-phenyl-amidosulfuric acid

C

3,5-Dimethyl-2-sulfoamino-benzenesulfonic acid

Conditions

Conditions	Yield
at 120℃; for 8h;	A n/a B 93% C n/a
at 160℃; for 8h;	A 74% B n/a C n/a

...Expand

2,4,2',4'-tetramethyldianilinium sulfate

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 180℃; under 60 Torr; for 0.833333h; Decomposition;	57.8%
at 210 - 250℃; Kinetics; Decomposition;

101861-78-3

2,4-dimethyl-phenyl-amidosulfuric acid

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 200 - 210℃; zuletzt bei 220-230grad;

132545-14-3

2,4-dimethyl-aniline; sulfate

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 210 - 230℃; unter vermindertem Druck;

95-68-1

2,4-Xylidine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 210 - 222℃; bei gewoenlichem Druck;
With sulfuric acid at 185 - 195℃;
With sulfuric acid at 210 - 230℃; im Vakuum;
With chlorosulfonic acid; 1,1,2,2-tetrachloroethane
(i) aq. H2SO4, (ii) (heating); Multistep reaction;

95-68-1

2,4-Xylidine

A

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

B

6370-23-6

2,4-dimethylaniline-5-sulfonic acid

Conditions

Conditions	Yield
With chlorosulfonic acid

7664-93-9

sulfuric acid

95-68-1

2,4-Xylidine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 185 - 190℃;

7790-94-5

chlorosulfonic acid

95-68-1

2,4-Xylidine

A

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

B

6370-23-6

2,4-dimethylaniline-5-sulfonic acid

...Expand

acidic sulfate of asymm. m-xylidine

acidic sulfate of asymm. m-xylidine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 160℃; man erhitzt dann auf 220grad;

neutral sulfate of asymm. m-xylidine

neutral sulfate of asymm. m-xylidine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 180 - 200℃; im Vakuum;

95-68-1

2,4-Xylidine

neutral sulfate of asymm. m-xylidine

neutral sulfate of asymm. m-xylidine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
at 210 - 220℃;

95-68-1

2,4-Xylidine

SO2

SO2

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: conc. H2SO4 / 20 °C 2: 210 - 250 °C View Scheme

110-01-0

thiophene

7664-93-9

sulfuric acid

95-68-1

2,4-Xylidine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

...Expand

109-08-0

2-Methylpyrazine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

silver carbonate

Ag(2-amino-3,5-dimethylbenzenesulfonate)(2-methylpyrazine)

Conditions

Conditions	Yield
With NH3 In water byproducts: CO2; Ag2CO3 added to aq. soln. of 2-amino-3,5-dimethylbenzenesulfonic acid, stirred for several min, ligand added, stirred for 15 min, aq. NH3 added dropwise; evapd. for 8 d at room temp.; elem. anal.;	76%

...Expand

290-37-9

1,4-pyrazine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

silver carbonate

Ag(2-amino-3,5-dimethylbenzenesulfonate)(pyrazine)

Conditions

Conditions	Yield
With NH3 In water byproducts: CO2; Ag2CO3 added to aq. soln. of 2-amino-3,5-dimethylbenzenesulfonic acid, stirred for several min, pyrazine added, stirred for 15 min, aq. NH3 added dropwise; evapd. for 8 d at room temp.; elem. anal.;	75%

...Expand

123-32-0

2,5-dimethyl-pyrazine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

silver carbonate

Ag(2-amino-3,5-dimethylbenzenesulfonate)(2,5-dimethylpyrazine)*H2O

Conditions

Conditions	Yield
With NH3 In water byproducts: CO2; Ag2CO3 added to aq. soln. of 2-amino-3,5-dimethylbenzenesulfonic acid, stirred for several min, ligand added, stirred for 15 min, aq. NH3 added dropwise; evapd. for 8 d at room temp.; elem. anal.;	71%

...Expand

108-50-9

2,6-dimethylpyrazine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

silver carbonate

Ag(2-amino-3,5-dimethylbenzenesulfonate)(2,6-dimethylpyrazine)

Conditions

Conditions	Yield
With NH3 In water byproducts: CO2; Ag2CO3 added to aq. soln. of 2-amino-3,5-dimethylbenzenesulfonic acid, stirred for several min, ligand added, stirred for 15 min, aq. NH3 added dropwise; evapd. for 8 d at room temp.; elem. anal.;	69%

...Expand

5910-89-4

2,3-dimethylpyrazine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

silver carbonate

Ag(2-amino-3,5-dimethylbenzenesulfonate)(2,3-dimethylpyrazine)

Conditions

Conditions	Yield
With NH3 In water byproducts: CO2; Ag2CO3 added to aq. soln. of 2-amino-3,5-dimethylbenzenesulfonic acid, stirred for several min, ligand added, stirred for 15 min, aq. NH3 added dropwise; evapd. for 8 d at room temp.; elem. anal.;	64%

...Expand

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

98491-30-6

2-iodo-3,5-dimethylbenzenesulfonic acid

Conditions

Conditions	Yield
Stage #1: 2-amino-3,5-dimethylbenzenesulfonic acid With sodium carbonate In water Stage #2: With sodium nitrite In water at 0℃; for 0.75h; Further stages;	23%

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

14452-34-7

2,4-dimethyl-6-nitrophenol

Conditions

Conditions	Yield
With nitrogen oxides; water

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

18023-22-8

3,5-dimethylbenzenesulfinic acid

Conditions

Conditions	Yield
Diazotization.durch Diazotieren und beim nachfolgendes Verkochen mit Alkohol;
durch Diazotieren und beim nachfolgendes Verkochen mit Hydrazin;

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

41825-73-4

2-bromo-4,6-dimethylaniline

Conditions

Conditions	Yield
With bromine

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

2707-22-4

2-amino-3,5-dimethyl-benzenesulfonyl fluoride

Conditions

Conditions	Yield
With fluorosulphonic acid

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

2-chloro-3,5-dimethyl-benzenesulfonyl chloride

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

2-amino-3,5-dimethyl-benzenesulfonyl chloride

Conditions

Conditions	Yield
With chlorosulphuric acid
With chlorosulphuric acid

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

2-chloro-3,5-dimethyl-benzenesulfonic acid amide

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

2-amino-3,5-dimethyl-6-nitro-benzenesulfonic acid

Conditions

Conditions	Yield
With sulfuric acid; nitric acid

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

2,4-dimethyl-6-sulfo-benzenediazonium-betaine

Conditions

Conditions	Yield
With sodium hydroxide; water; sodium nitrite at 20℃; und saeuert man unter Kuehlung mit Salzsaeure an;

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

95-68-1

2,4-Xylidine

Conditions

Conditions	Yield
With hydrogenchloride at 150 - 155℃;

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

7732-18-5

water

nitrogen oxides

nitrogen oxides

14452-34-7

2,4-dimethyl-6-nitrophenol

...Expand

88-22-2

2-amino-3,5-dimethylbenzenesulfonic acid

HNO3+H2SO4

HNO3+H2SO4

2-amino-3,5-dimethyl-6-nitro-benzenesulfonic acid

2,4-Dimethylaniline-6-sulfonic acid Chemical Properties

The molecular formula of 2,4-Dimethylaniline-6-sulfonic acid(88-22-2) is C₈H₁₁NO₃S and its formula weight is 201.24.
The density of 2,4-Dimethylaniline-6-sulfonic acid(88-22-2) is 1.368 g/cm³. The refractive index is about  1.595 .
The chemical synonyms of 2,4-Dimethylaniline-6-sulfonic acid(88-22-2) are 2-amino-3,5-dimethyl-benzenesulfonicaci;M-XYLIDINE-6-SULFONIC ACID;2,4-DIMETHYLANILINE-6-SULFONIC ACID;2-Amino-3,5-xylenesulphonic acid;2,4-Dimethylanilinde-6-sulfonic acid;2,4-xylidine-6-sulphonic acid;2,4-Xylidine-6-sulfonic acid (NH2=1);2-amino-3,5-dimethylbenzenesulfonic acid
The molecular structure of 2,4-Dimethylaniline-6-sulfonic acid(88-22-2):

2,4-Dimethylaniline-6-sulfonic acid Safety Profile