2,5-DICHLORO-4-NITROANILINE supplier

Name
2,5-DICHLORO-4-NITROANILINE
EINECS 229-591-5
CAS No. 6627-34-5
Article Data9
CAS DataBase
Density 1.624g/cm³
Solubility
Melting Point 150-155 ºC
Formula C6H4 Cl2 N2 O2
Boiling Point 361.1°C at 760 mmHg
Molecular Weight 207.016
Flash Point 172.2°C
Transport Information
Appearance yellow powder
Safety Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Risk Codes R36/37/38
Molecular Structure
Hazard Symbols
Synonyms Aniline,2,5-dichloro-4-nitro- (7CI,8CI); 2,5-Dichloro-4-nitroaniline;2,5-Dichloro-4-nitrophenylamine; NSC 60645
PSA 71.84000
LogP 3.58820

Synthetic route

: 17488-25-4
1,4-dichloro-2,5-dinitrobenzene

: 6627-34-5
2,5-dichloro-4-nitroaniline

Conditions

Conditions	Yield
With ammonia

: 17488-25-4
1,4-dichloro-2,5-dinitrobenzene

A: 6627-34-5
2,5-dichloro-4-nitroaniline

B: 67382-07-4
2,5-dinitro-p-phenylenediamine

Conditions

Conditions	Yield
With ethanol; ammonia

: 2621-62-7
2,5-dichloroacetanilide

: 6627-34-5
2,5-dichloro-4-nitroaniline

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at 5 - 10℃; folgendes Verseifen mit verd.Natronlauge;
With nitrating mixture; sulfuric acid at 45℃; das Acetylderivat entsteht;
Multi-step reaction with 2 steps 1: nitration 2: hydrolysis View Scheme

: 2621-62-7
2,5-dichloroacetanilide

A: 6627-34-5
2,5-dichloro-4-nitroaniline

B: 38411-18-6
acetic acid-(3,6-dichloro-2-nitro-anilide)

Conditions

Conditions	Yield
With nitric acid man extrahiert das 2.5-Dichlor-4-nitro-acetanilid durch Auskochen mit Benzol; die Benzolloesung dampft man ein und zersetzt das asgeschiedene Acetylderivat durch Erhitzen mit waessr.Ammoniak auf 180grad;

: 38411-17-5
2,5-dchloro-4-nitroacetanilide

: 6627-34-5
2,5-dichloro-4-nitroaniline

Conditions

Conditions	Yield
With sulfuric acid at 100 - 110℃;
hydrolysis;

: 17488-25-4
1,4-dichloro-2,5-dinitrobenzene

: 7664-41-7
ammonia

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 17488-25-4
1,4-dichloro-2,5-dinitrobenzene

: 7664-41-7
ammonia

A: 6627-34-5
2,5-dichloro-4-nitroaniline

B: 67382-07-4
2,5-dinitro-p-phenylenediamine

...Expand

: 2621-62-7
2,5-dichloroacetanilide

HNO3+H2SO4: HNO3+H2SO4

: 6627-34-5
2,5-dichloro-4-nitroaniline

Conditions

Conditions	Yield
und Verseifen mit Natronlauge;

: 106-46-7
para-dichlorobenzene

: 6627-34-5
2,5-dichloro-4-nitroaniline

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: HNO3+H2SO4 2: alcoholic ammonia View Scheme
Multi-step reaction with 2 steps 1: HNO3+H2SO4 2: alcohol; ammonia View Scheme

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 130-15-4
[1,4]naphthoquinone

: 20103-09-7
2,5-dichloro-1,4-phenylenediamine

Conditions

Conditions	Yield
With sodium hydroxide; hydrazine hydrate In water	96%
With sodium hydroxide; hydrazine hydrate In water	91%

: 24424-99-5
di-tert-butyl dicarbonate

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 1301264-10-7
di-tert-butyl-2,5-dichloro-4-nitrophenylimidodicarbonate

Conditions

Conditions	Yield
dmap In tetrahydrofuran at 20℃;	91%

: 1843-05-6
Cyasorb UV531

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 1-[2-hydroxy-4-n-octyloxy-5-(2,5-dichloro-4-nitrophenylazo)phenyl]-1-phenylmethanone

Conditions

Conditions	Yield
Stage #1: 2,5-dichloro-4-nitroaniline With hydrogenchloride; sodium nitrite In water at 0 - 5℃; for 0.5h; Stage #2: Cyasorb UV531 With sodium carbonate; sodium hydroxide In water at 0 - 20℃; for 2.5h; pH=2 - 3;	78%

: 20877-02-5
2-thio-N,N-dimethylbenzamide

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 474432-18-3
2-(5-Amino-4-chloro-2-nitro-phenylthio)-N,N-dimethyl-benzamide

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 24h; Heating;	75%
With potassium carbonate In DMF (N,N-dimethyl-formamide) for 24h; Heating / reflux;	75%

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 75-36-5
acetyl chloride

: 38411-17-5
2,5-dchloro-4-nitroacetanilide

Conditions

Conditions	Yield
With sodium carbonate In acetone for 1h; Reflux;	75%

: 67-56-1
methanol

: 14510-06-6
2-formyl oxine

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 2-[(2,5-dichloro-4-nitro-phenylamino)-methoxy-methyl]-quinolin-8-ol

Conditions

Conditions	Yield
With piperidine for 2h; Heating;	35%

...Expand

: 5414-19-7
1,1'-oxybis(2-bromo-ethane)

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 1023311-12-7
4-(2,5-dichloro-4-nitro-phenyl)-morpholine

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile for 17h; Heating / reflux;	19.97%

: 110-91-8
morpholine

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 103505-31-3
2-chloro-5-morpholino-4-nitro-aniline

: 67-56-1
methanol

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 24311-36-2
2-chloro-5-methoxy-4-nitro-aniline

Conditions

Conditions	Yield
With sodium hydroxide

: 6627-34-5
2,5-dichloro-4-nitroaniline

A: 95-94-3
1,2,4,5-tetrachlorobenzene

B: 89-69-0
2,4,5-Trichloronitrobenzene

Conditions

Conditions	Yield
Diazotieren und Behandeln mit salzsaurer Kupfer(I)-chlorid-Loesung;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 17488-25-4
1,4-dichloro-2,5-dinitrobenzene

Conditions

Conditions	Yield
Diazotization.Behandeln mit Natriumnitrit;
With dihydrogen peroxide; trifluoroacetic acid

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 7145-82-6
2,4,5-trichloroiodobenzene

Conditions

Conditions	Yield
With hydrogenchloride; acetic acid Diazotization.Eintragen von KI in die Diazoniumsalz-Loesung;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 5847-57-4
2,5-dichloro-4-nitrophenol

Conditions

Conditions	Yield
With sulfuric acid; sodium nitrite anschliessendes Erwaermen mit Wasser;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 62406-69-3
2,3,6-trichloro-4-nitro-aniline

Conditions

Conditions	Yield
With hydrogenchloride; potassium chlorate at 10 - 15℃;
With sulfuryl dichloride
With hydrogenchloride; dihydrogen peroxide In water

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 20103-09-7
2,5-dichloro-1,4-phenylenediamine

Conditions

Conditions	Yield
bei Reduktion;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 71350-52-2
1,4-dichloro-2-iodo-5-nitro-benzene

Conditions

Conditions	Yield
With sulfuric acid; water; acetic acid at 0℃; Diazotization.Erwaermen der Diazoniumsalz-Loesung mit KI auf 70grad;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 22636-22-2
3,6-dichloro-2,4-dinitro-aniline

Conditions

Conditions	Yield
With sulfuric acid; nitric acid at -15℃;
With nitric acid at -15℃; Eintragen des erhaltenen 2.5-Dichlor-4.N-dinitro-anilins in Schwefelsaeure;
With nitric acid at -15℃; Eintragen des erhaltenen 2.5-Dichlor-4.N-dinitro-anilins in Schwefelsaeure;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 2-amino-3,6-dichloro-5-nitro-benzenesulfonic acid

Conditions

Conditions	Yield
With tetrachloromethane; chlorosulphuric acid zuletzt in 1.2-Dichlor-benzol bei 160grad;

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 98-88-4
benzoyl chloride

: 99282-29-8
benzoic acid-(2,5-dichloro-4-nitro-anilide)

Conditions

Conditions	Yield
With sodium hydroxide

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 98-09-9
benzenesulfonyl chloride

: 107342-09-6
benzenesulfonic acid-(2,5-dichloro-4-nitro-anilide)

: 764-85-2
Nonanoyl chloride

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 6043-38-5
Nonanoic acid (2,5-dichloro-4-nitro-phenyl)-amide

Conditions

Conditions	Yield
In toluene

: 107-03-9
1-thiopropane

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 69951-07-1
2-chloro-4-nitro-5-n-propylthioaniline

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide

: 6374-26-1
diethyl phosphorisothiocyanatidate

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 69950-92-1
C16H26Cl2N4O6P2S2

Conditions

Conditions	Yield
(i) SnCl2, aq. HCl, (ii) /BRN= 1708449/, CHCl3; Multistep reaction;

: 358-23-6
trifluoromethylsulfonic anhydride

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 57946-26-6
N-(2,5-Dichloro-4-nitro-phenyl)-C,C,C-trifluoro-methanesulfonamide

: 392-95-0
1-chloro-2,4-dinitro-6-trifluoromethylbenzene

: 6627-34-5
2,5-dichloro-4-nitroaniline

: 57730-08-2
2,5-dichloro-2',4,4'-trinitro-6'-trifluoromethyldiphenylamine

2,5-DICHLORO-4-NITROANILINE Chemical Properties

Empirical Formula: C₆H₄Cl₂N₂O₂
Molecular Weight: 207.0142
IUPAC Name: 2,5-Dichloro-4-nitroaniline
Synonyms: 2,5-Dichloro-4-nitro-anilin ; Benzenamine,2,5-dichloro-4-nitro- ; 2,5-Dichloro-4-nitrobenzenamine ; Aniline, 2,5-dichloro-4-nitro-
Melting Point: 154-158 ^°C(lit.)
Flash Point of 2,5-Dichloro-4-nitroaniline (6627-34-5): 172.2^°C
Boiling Point: 361.1 ^°C at 760 mmHg
Density of 2,5-Dichloro-4-nitroaniline (6627-34-5): 1.624 g/cm³
Vapour Pressure: 2.12E-05 mmHg at 25^°C
Index of Refraction: 1.655
Physical State: 2,5-Dichloro-4-nitroaniline (6627-34-5) is a yellow powder

2,5-DICHLORO-4-NITROANILINE Toxicity Data With Reference

orl-rat LD50:2820 mg/kg

85JCAE Prehled Prumyslove Toxikologie; Organicke Latky Marhold, J.,Prague, Czechoslovakia.: Avicenum,1986,599.

2,5-DICHLORO-4-NITROANILINE Consensus Reports

Reported in EPA TSCA Inventory.

2,5-DICHLORO-4-NITROANILINE Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Safety: WARNING: Irritates lungs, eyes, skin
Hazard Codes: Xi: Irritant
Risk Statements: 36/37/38: Irritating to eyes, respiratory system and skin
Safety Statements: 26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
37/39: Wear suitable gloves and eye/face protection
RIDADR: 2811
WGK Germany: 3
RTECS: BX2950000

2,5-DICHLORO-4-NITROANILINE Specification

2,5-Dichloro-4-nitroaniline (6627-34-5) is a yellow powder, which should store in a cool, dry place with a tightly closed container.

Product Name

2,5-DICHLORO-4-NITROANILINE

Synthetic route

2,5-DICHLORO-4-NITROANILINE Chemical Properties

2,5-DICHLORO-4-NITROANILINE Toxicity Data With Reference

2,5-DICHLORO-4-NITROANILINE Consensus Reports

2,5-DICHLORO-4-NITROANILINE Safety Profile

2,5-DICHLORO-4-NITROANILINE Specification

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