2,5-Dichloropyridine

The 2,5-Dichloropyridine is an organic compound with the formula C₅H₃Cl₂N. The IUPAC name of this chemical is 2,5-dichloropyridine. With the CAS registry number 16110-09-1, it is also named as Pyridine, 2,5-dichloro-. The product's categories are Pyridine; Pyridine Derivative; Pyridines, Pyrimidines, Purines and Pteredines; Halides; Pyridines; Chloropyridines; Halopyridines; Boronic Acid; C5Heterocyclic Building Blocks; Halogenated Heterocycles; Heterocyclic Building Blocks; Chlorinated Heterocyclic Series. Besides, it is a white to slightly yellow crystalline solid.

Physical properties about 2,5-Dichloropyridine are: (1)ACD/LogP: 2.17; (2)ACD/LogD (pH 5.5): 2.17; (3)ACD/LogD (pH 7.4): 2.17; (4)ACD/BCF (pH 5.5): 26.17; (5)ACD/BCF (pH 7.4): 26.17; (6)ACD/KOC (pH 5.5): 360.13; (7)ACD/KOC (pH 7.4): 360.13; (8)#H bond acceptors: 1; (9)Polar Surface Area: 12.89 Å²; (10)Index of Refraction: 1.553; (11)Molar Refractivity: 34.13 cm³; (12)Molar Volume: 106.5 cm³; (13)Polarizability: 13.53×10^-24cm³; (14)Surface Tension: 43.1 dyne/cm; (15)Density: 1.388 g/cm³; (16)Flash Point: 83.1 °C; (17)Enthalpy of Vaporization: 40.55 kJ/mol; (18)Boiling Point: 186.6 °C at 760 mmHg; (19)Vapour Pressure: 0.904 mmHg at 25°C.

Preparation: this chemical can be prepared by 5-chloro-2-methoxy-pyridine. This reaction will need reagent phosphoryl chloride and solvent dimethylformamide. The reaction time is 14 hours with reaction temperature of 100 °C. The yield is about 69%.

Uses of 2,5-Dichloropyridine: it can be used to produce 1-(5-chloro-2-pyridinyl)piperazine at room temperature. It will need reagent ethanol.

When you are using this chemical, please be cautious about it as the following:
It is harmful if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Besides, this chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection.

You can still convert the following datas into molecular structure:
(1)SMILES: c1cc(ncc1Cl)Cl
(2)InChI: InChI=1/C5H3Cl2N/c6-4-1-2-5(7)8-3-4/h1-3H
(3)InChIKey: GCTFDMFLLBCLPF-UHFFFAOYAP
(4)Std. InChI: InChI=1S/C5H3Cl2N/c6-4-1-2-5(7)8-3-4/h1-3H
(5)Std. InChIKey: GCTFDMFLLBCLPF-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	intraperitoneal	1690mg/kg (1690mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ANTIPSYCHOTIC LIVER: FATTY LIVER DEGERATION	Toxicology and Applied Pharmacology. Vol. 11, Pg. 361, 1967.