• Name

  4-Hydroxy-2,6-dimethylpyridine

• EINECS 237-089-2
• CAS No. 13603-44-6
• Article Data24
• CAS DataBase
• Density 1.013 g/cm³
• Solubility
• Melting Point 230-232 °C
• Formula C₇H₉NO
• Boiling Point 205.4 °C at 760 mm
• Molecular Weight 123.155
• Flash Point 93.1 °C
• Transport Information
• Appearance yellow to brown cryst
• Safety 26-36
• Risk Codes 36/37/38
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 2,6-Dimethyl-4-pyridinol;4-Hydroxy-2,6-dimethylpyridine;4-Hydroxy-2,6-lutidine;NSC 111932;
• PSA 33.12000
• LogP 1.40400

Synthetic route

520-45-6

Dehydracetic acid

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With ammonia In water at 120℃; for 0.333333h; Microwave irradiation;	100%
With ammonia In water at 120℃; for 0.333333h; Microwave irradiation;	100%
With ammonia In water at 120℃; for 0.333333h; microwave irradiation;	100%

5093-70-9

4-bromo-2,6-dimethylpyridine

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With syn-benzaldehyde oxime; N1,N2-bis(thiophen-2-ylmethyl)oxalamide; caesium carbonate; copper(l) chloride In dimethyl sulfoxide at 80℃; for 20h; Reagent/catalyst; Temperature; Glovebox; Schlenk technique; Sealed tube; Inert atmosphere;	50%

1004-36-0

2,6-dimethylpyrone

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With ammonium hydroxide at 100℃;
With ammonia at 25℃;
With ammonium hydroxide

3512-75-2

4-chloro-2,6-lutidine

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With sodium acetate; acetic acid at 200℃; Erhitzen des Reaktionsprodukts mit wss.Salzsaeure;

3512-80-9

4-amino-2,6-lutidine

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With sulfuric acid; water; sodium nitrite

70271-80-6

ethyl 4-chloro-2,6-dimethylnicotinate

13603-44-6

2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With hydrogenchloride at 150℃;

358-23-6

trifluoromethylsulfonic anhydride

13603-44-6

2,6-dimethylpyridin-4-ol

129558-60-7

trifluoromethanesulfonic acid 2,6-dimethylpyridin-4-yl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;	100%
With triethylamine In dichloromethane at 0 - 20℃; for 2.08333h;	100%
Stage #1: 2,6-dimethylpyridin-4-ol With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: trifluoromethylsulfonic anhydride; dmap In dichloromethane at 20℃; for 6h;	79%

13603-44-6

2,6-dimethylpyridin-4-ol

3,5-dibromo-2,6-dimethylpyridin-4-ol hydrobromide

Conditions

Conditions	Yield
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Temperature; Reagent/catalyst;	96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h;	96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Reagent/catalyst; Temperature;	96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Concentration; Reagent/catalyst; Temperature;	96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Concentration; Reagent/catalyst; Temperature;	96%

13603-44-6

2,6-dimethylpyridin-4-ol

3,5-dibromo-2,6-dimethylpyridin-4-ol hydrobromide

Conditions

Conditions	Yield
With bromine; tert-butylamine In methanol; dichloromethane at 20℃; for 2.66667h;	96%
With diisobutylamine; bromine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Reagent/catalyst;	96%
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h;	96%

13603-44-6

2,6-dimethylpyridin-4-ol

4563-28-4

3,5-dibromo-2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With bromine; tert-butylamine In methanol; dichloromethane at 5 - 20℃; for 2.66667h; Temperature;	96%
With 4-methyl-morpholine; bromine In methanol; dichloromethane at 20℃; for 2h;	88%
With 4-methyl-morpholine; bromine In methanol; dichloromethane at 20℃; for 2h; Reagent/catalyst; Temperature; Cooling with ice;	88%

13603-44-6

2,6-dimethylpyridin-4-ol

200112-75-0

3-(perfluorooctyl)propyl iodide

C18H14F17NO

Conditions

Conditions	Yield
Stage #1: 2,6-dimethylpyridin-4-ol With 18-crown-6 ether; potassium carbonate In acetone at 20℃; for 0.666667h; Inert atmosphere; Stage #2: 3-(perfluorooctyl)propyl iodide In acetone at 20℃; for 10.08h; Inert atmosphere; Reflux;	95%

1193-21-1

4,6-dichloropyrimidine

13603-44-6

2,6-dimethylpyridin-4-ol

1231749-84-0

6-chloro-N-(2,6-dimethylpyridin-4-yl)pyrimidin-4-amine

Conditions

Conditions	Yield
Stage #1: 2,6-dimethylpyridin-4-ol With sodium hydride In N,N-dimethyl-formamide; mineral oil for 0.25h; Stage #2: 4,6-dichloropyrimidine In N,N-dimethyl-formamide; mineral oil at 20℃;	46%

13603-44-6

2,6-dimethylpyridin-4-ol

85217-69-2, 87802-71-9

cinnamyl methyl carbonate

A

C14H13NS

B

C16H17NO

Conditions

Conditions	Yield
With bis(1,5-cyclooctadiene)diiridium(I) dichloride; 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; 1,8-diazabicyclo[5.4.0]undec-7-ene; (3,5-Dioxa-4-phospha-cyclohepta[2,1-a;3,4-a']dinaphthalen-4-yl)-bis-((R)-1-phenyl-ethyl)-amine In tetrahydrofuran at 50℃; for 8h; Inert atmosphere; stereoselective reaction;	A 44% B 46%

...Expand

13603-44-6

2,6-dimethylpyridin-4-ol

129940-50-7

(S)-tritylglycidol

(S)-1-((2,6-dimethylpyridin-4-yl)oxy)-3-(trityloxy)propan-2-ol

Conditions

Conditions	Yield
With potassium carbonate In ethanol Reflux;	45%

13603-44-6

2,6-dimethylpyridin-4-ol

96-32-2

bromoacetic acid methyl ester

1572184-94-1

methyl 2-(2,6-dimethylpyridin-4-yloxy)acetate

Conditions

Conditions	Yield
With caesium carbonate In acetonitrile at 80℃; for 1h;	42%

13603-44-6

2,6-dimethylpyridin-4-ol

3-iodo-2,6-dimethylpyridin-4-ol

Conditions

Conditions	Yield
With iodine; sodium carbonate In water at 20℃;	40%

13603-44-6

2,6-dimethylpyridin-4-ol

100-52-7

benzaldehyde

856969-42-1

2,6-distyrylpyridin-4-ol

Conditions

Conditions	Yield
With acetic anhydride for 288h; Inert atmosphere; Reflux;	38%

13603-44-6

2,6-dimethylpyridin-4-ol

C16H29ClN2O5

C23H37N3O6

Conditions

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide at 25℃; for 1h;	24.24%

13603-44-6

2,6-dimethylpyridin-4-ol

1-benzyl 4-(tert-butyl) (2S,5S)-2-(bromomethyl)-5-methylpiperazine-1,4-dicarboxylate

1-benzyl 4-(tert-butyl) (2S,5S)-2-(((2,6-dimethylpyridin-4-yl)oxy)methyl)-5-methylpiperazine-1,4-dicarboxylate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 2h;	12%

13603-44-6

2,6-dimethylpyridin-4-ol

103-71-9

phenyl isocyanate

71-43-2

benzene

86775-90-8

(2,6-dimethyl-pyridin-4-yl)-phenyl-amine

Conditions

Conditions	Yield
at 100 - 150℃;

...Expand

13603-44-6

2,6-dimethylpyridin-4-ol

90000-67-2

2,6-dimethyl-4-mercaptopyridine

Conditions

Conditions	Yield
With pyridine; phosphorous (V) sulfide

2,6-Dimethyl-4-hydroxypyridine Chemical Properties

Molecular Formula: C₇H₉NO
Formula Weight: 123.15
mp of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): 230-232^°C
bp of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): 351 ^°C
Flash Point: 93.1 ^°C 
density of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): 1,053g/cm³
Vapour Pressure: 0.251 mmHg at 25^°C 
refractive index : 1,501-1,503
Appearence of 2,6-Dimethyl-4-hydroxypyridine (13603-44-6): Yellow to Brown Crystal

2,6-Dimethyl-4-hydroxypyridine Toxicity Data With Reference

2,6-Dimethyl-4-hydroxypyridine Safety Profile

2,6-Dimethyl-4-hydroxypyridine Specification