• Name

  2-AMINOTHIAZOLE-5-CARBOXYLIC ACID

• EINECS
• CAS No. 40283-46-3
• Article Data6
• CAS DataBase
• Density 1.657 g/cm³
• Solubility
• Melting Point 214-216 °C
• Formula C₄H₄N₂O₂S
• Boiling Point 415 °C at 760 mmHg
• Molecular Weight 144.154
• Flash Point 204.8 °C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols Xi
• Synonyms 2-Amino-5-thiazolecarboxylicacid;NSC 239729;
• PSA 104.45000
• LogP 1.00470

Synthetic route

32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water Reflux;	86%
With sodium hydroxide
With barium dihydroxide
With potassium hydroxide In methanol

6633-61-0

methyl 2-aminothiazole-5-carboxylate

40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions

Conditions	Yield
With sodium hydroxide Ambient temperature;	74%

99903-61-4

2-acetylamino-thiazole-5-carbonitrile

40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions

Conditions	Yield
With hydrogenchloride

40283-46-3

2-aminothiazole-5-carboxylic acid

108-24-7

acetic anhydride

1170060-19-1

2-(acetylamino)thiazole-5-carboxylic acid

Conditions

Conditions	Yield
With pyridine at 20 - 130℃;	71%

40283-46-3

2-aminothiazole-5-carboxylic acid

745053-64-9

5-fluoro-1,3-thiazol-2-amine hydrochloride

Conditions

Conditions	Yield
Stage #1: 2-aminothiazole-5-carboxylic acid With potassium phosphate In 1,4-dioxane; methanol; toluene at 20℃; for 2h; Stage #2: With 1-(chloromethyl)-4-fluoro-1,4-diazabicyclo[2.2.2]octane-1,4-diium tetrafluoroborate In 1,4-dioxane; methanol; toluene at 20℃; for 0.5h; Stage #3: With hydrogenchloride In 1,4-dioxane; methanol; toluene Product distribution / selectivity;	69%

50-00-0

formaldehyd

40283-46-3

2-aminothiazole-5-carboxylic acid

5424-01-1

3-aminopyrazinoic acid

2-(4-oxopteridin-3(4H)-yl)thiazole-5-carboxylic acid

Conditions

Conditions	Yield
In ethanol for 6h; Reflux;	44%

...Expand

40283-46-3

2-aminothiazole-5-carboxylic acid

103-49-1

dibenzylamine

2-amino-N,N-dibenzylthiazole-5-carboxamide

Conditions

Conditions	Yield
Stage #1: 2-aminothiazole-5-carboxylic acid With 4-methyl-morpholine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate In N,N-dimethyl-formamide at 0℃; for 0.5h; Stage #2: dibenzylamine In N,N-dimethyl-formamide at 20℃;	41%

40283-46-3

2-aminothiazole-5-carboxylic acid

7252-53-1

(aminomethyl)cyclopropane hydrochloride

1152209-96-5

N-cyclopropylmethyl-2-aminothiazole-5-carboxamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;

40283-46-3

2-aminothiazole-5-carboxylic acid

150812-09-2

1-cyclopentylethyl amine hydrochloride

1152210-00-8

N-(1-cyclopentylethyl)-2-aminothiazole-5-carboxamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;

40283-46-3

2-aminothiazole-5-carboxylic acid

cyclopropylmethyl-amine hydrochloride

1152210-06-4

N-cyclopentylmethyl-2-aminothiazole-5-carboxamide

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;

40283-46-3

2-aminothiazole-5-carboxylic acid

24424-99-5

di-tert-butyl dicarbonate

302964-02-9

2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylic acid

Conditions

Conditions	Yield
Stage #1: 2-aminothiazole-5-carboxylic acid; di-tert-butyl dicarbonate With sodium hydroxide In tetrahydrofuran; water at 0 - 25℃; for 24h; Industry scale; Stage #2: With acetic acid In tetrahydrofuran; water at 0 - 5℃; for 1h; pH=4.9; Industry scale;

40283-46-3

2-aminothiazole-5-carboxylic acid

1350643-72-9

(S)-3-(1-aminoethyl)-8-chloro-2-phenylisoquinoline-1(2H)-one

1466563-34-7

(S)-2-amino-N-(1-(8-chloro-1-oxo-2-phenyl-1,2-dihydroisoquinolin-3-yl)ethyl)thiazole-5-carboxamide

Conditions

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃;

40283-46-3

2-aminothiazole-5-carboxylic acid

(S)-2-((S)-2-amino-4-phenylbutanamido)-4-methyl-N-((S)-1-(((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)amino)-1-oxo-3-phenylpropan-2-yl)pentanamide 2,2,2-trifluoroacetate

1545468-62-9

C38H50N6O6S

Conditions

Conditions	Yield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In N,N-dimethyl-formamide at 20℃;

40283-46-3

2-aminothiazole-5-carboxylic acid

91-66-7

N,N-diethylaniline

C14H16N4O2S

Conditions

Conditions	Yield
Stage #1: 2-aminothiazole-5-carboxylic acid With phosphoric acid; sulfuric acid; sodium nitrite In water at -5 - 0℃; for 5h; Stage #2: N,N-diethylaniline With sodium hydroxide In water at -5 - 0℃; for 3h;

40283-46-3

2-aminothiazole-5-carboxylic acid

79-31-2

isobutyric Acid

2-isobutyramidothiazole-5-carboxylic acid

Conditions

Conditions	Yield
at 100℃;

2-Amino-1,3-thiazole-5-carboxylic acid Chemical Properties

2-Amino-1,3-thiazole-5-carboxylic acid Safety Profile