• Name

  2-Amino-2'-fluoro-5-nitrobenzophenone

• EINECS 206-454-8
• CAS No. 344-80-9
• Density 1.399 g/cm³
• Solubility
• Melting Point 158-160°C
• Formula C₁₃H₉FN₂O₃
• Boiling Point 485.6 °C at 760 mmHg
• Molecular Weight 260.224
• Flash Point 247.5 °C
• Transport Information
• Appearance yellow crystalline powder
• Safety 24/25
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 2-amino-5-nitro-2'-fluoro benzophenone;Benzophenone,2-amino-2'-fluoro-5-nitro- (7CI,8CI);2-Amino-5-nitro-2'-fluorobenzophenone;
• PSA 88.91000
• LogP 3.65150

Synthetic route

2558-30-7

5-(2-fluorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

Conditions

Conditions	Yield
With hydrogenchloride In ethanol Heating;

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

79-04-9

chloroacetyl chloride

2‑(2‑chloroacetamido)‑5‑nitro‑2′‑fluorobenzophenone

Conditions

Conditions	Yield
In dichloromethane at 0 - 20℃; for 12h;	95%

623-73-4

diazoacetic acid ethyl ester

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

C17H15FN2O5

Conditions

Conditions	Yield
With 1-methylimidazolium tetrafluoroborate In neat (no solvent) at 20℃; for 2h;	90%

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

1138-80-3

N-(Benzyloxycarbonyl)glycine

Benzyl{[[2-(o-fluorobenzoyl)-4-nitrophenyl]carbamoyl]methyl}-carbamate

Conditions

Conditions	Yield
With thionyl chloride; sodium hydrogencarbonate In tetrahydrofuran; ethyl acetate

1142-20-7

N-Cbz-Ala

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

59937-53-0

(S)-benzyl-{1-[[2-(o-fluorobenzoyl)-4-nitrophenyl]carbamoyl]ethyl}carbamate

Conditions

Conditions	Yield
With thionyl chloride; sodium hydrogencarbonate In tetrahydrofuran

97-97-2

chloroacetaldehyde dimethyl acetal

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

59468-08-5

2-chloromethyl-4-(2-fluoro-phenyl)-6-nitro-1,2-dihydro-quinazoline 3-oxide

Conditions

Conditions	Yield
With hydrogenchloride In ethanol

1142-20-7

N-Cbz-Ala

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

74892-38-9

(-)-benzyl-[1-[{2-(o-fluorobenzoyl)-4-nitrophenyl}-carbamoyl]ethyl]carbamate

Conditions

Conditions	Yield
With phosphorus pentachloride In dichloromethane; toluene

2-(α-bromo-α-fluoroacetamido)-5-nitro-2'-fluorobenzophenone

359-22-8

bromo-fluoro-acetyl bromide

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

A

2-(α-amino-α-fluoroacetamido)-5-nitro-2'-fluorobenzophenone

B

60628-63-9

3-fluoro-5-o-fluorophenyl-7-nitro-2,3-dihydro-1H-1,4-benzodiazepin-2-one

Conditions

Conditions	Yield
With hexamethylenetetramine In ethanol

...Expand

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

7-amino-2-aminomethyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1: hydrogenchloride / ethanol 2: manganese dioxide / tetrahydrofuran; dichloromethane 3: acetic acid / nitromethane; dichloromethane; dimethyl sulfoxide 4: ethanol View Scheme

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

1,3-dihydro-5-(2-fluorophenyl)-7-nitro-2-nitromethylene-2H-1,4-benzodiazepine 4-oxide

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: hydrogenchloride / ethanol 2: manganese dioxide / tetrahydrofuran; dichloromethane 3: acetic acid / nitromethane; dichloromethane; dimethyl sulfoxide View Scheme

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

59468-09-6

2-chloromethyl-4-(2-fluoro-phenyl)-6-nitro-quinazoline 3-oxide

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: hydrogenchloride / ethanol 2: manganese dioxide / tetrahydrofuran; dichloromethane View Scheme

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

2558-30-7

5-(2-fluorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: dichloromethane / 12 h / 0 - 20 °C 2: hexamethylenetetramine; ammonium chloride / ethanol / 4 h / Reflux View Scheme

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

C19H19FN3O6P

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1.1: dichloromethane / 12 h / 0 - 20 °C 2.1: hexamethylenetetramine; ammonium chloride / ethanol / 4 h / Reflux 3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 3.2: 0.58 h / -20 - 0 °C / Inert atmosphere View Scheme

344-80-9

2-amino-5-nitro-2'-fluorobenzophenone

8‑nitro‑6‑(2‑fluorophenyl)‑3‑(4‑toluenesulfonyl)‑4H‑imidazo[1,5‑a][1,4]benzodiazepine

Conditions

Conditions	Yield
Multi-step reaction with 4 steps 1.1: dichloromethane / 12 h / 0 - 20 °C 2.1: hexamethylenetetramine; ammonium chloride / ethanol / 4 h / Reflux 3.1: potassium tert-butylate / tetrahydrofuran / 0.33 h / 0 °C / Inert atmosphere 3.2: 0.58 h / -20 - 0 °C / Inert atmosphere 4.1: potassium tert-butylate / tetrahydrofuran / 4 h / -20 - 20 °C / Inert atmosphere View Scheme

2-Amino-2'-fluoro-5-nitrobenzophenone Chemical Properties