Product Name

  • Name

    2-Amino-5-bromine-2'-chloro benzophenone

  • EINECS
  • CAS No. 60773-49-1
  • Article Data5
  • CAS DataBase
  • Density 1.568 g/cm3
  • Solubility
  • Melting Point 85-87°C
  • Formula C13H9BrClNO
  • Boiling Point 456.2 °C at 760 mmHg
  • Molecular Weight 310.578
  • Flash Point 229.7 °C
  • Transport Information
  • Appearance yellow crystal powder
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 60773-49-1 (2-Amino-5-bromine-2'-chloro benzophenone)
  • Hazard Symbols
  • Synonyms 5-Bromo-2'-chloro-2-aminobenzophenone;
  • PSA 43.09000
  • LogP 4.49690

Synthetic route

2-amino-5-bromobenzonitrile
39263-32-6

2-amino-5-bromobenzonitrile

2-Chlorobenzeneboronic acid
3900-89-8

2-Chlorobenzeneboronic acid

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate In 2-methyltetrahydrofuran; water at 80℃; for 36h;58%
o-chlorobenzoyl chloride
609-65-4

o-chlorobenzoyl chloride

4-bromo-aniline
106-40-1

4-bromo-aniline

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
Stage #1: o-chlorobenzoyl chloride; 4-bromo-aniline at 0 - 120℃; for 1h;
Stage #2: With zinc(II) chloride at 120 - 195℃; for 3h;
Stage #3: With hydrogenchloride; sulfuric acid; water more than 3 stages;		37%
(i) ZnCl2, (ii) aq. HCl, (iii) H2SO4; Multistep reaction;
3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one
70030-11-4

3-hydroxy-7-bromo-5-(2'-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; boiling water bath;
phenazepam
51753-57-2

phenazepam

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

Conditions
ConditionsYield
With hydrogenchloride for 0.5h; boiling water bath;
N-phthaloylglycine chloride
6780-38-7

N-phthaloylglycine chloride

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone
87213-48-7

5-bromo-2'-chloro-2-(phthalimidoacetamido)benzophenone

Conditions
ConditionsYield
In chloroform for 5h; Heating;97%
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

2-amino-5-bromo-4'-chlorobenzhydrol
89445-68-1

2-amino-5-bromo-4'-chlorobenzhydrol

Conditions
ConditionsYield
With sodium tetrahydroborate In water at 25 - 30℃; for 2h;96%
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

C(14)CH4ClNO*ClH

C(14)CH4ClNO*ClH

3-[14C]-7-bromo-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one

3-[14C]-7-bromo-5-(o-chlorophenyl)-1,2-dihydro-3H-1,4-benzodiazepin-2-one

Conditions
ConditionsYield
Condensation;90%
sodium cyanide
773837-37-9

sodium cyanide

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

4-amino-3-(2-chlorobenzoyl)benzonitrile
17562-66-2

4-amino-3-(2-chlorobenzoyl)benzonitrile

Conditions
ConditionsYield
With copper(l) iodide; potassium iodide; N,N`-dimethylethylenediamine In 5,5-dimethyl-1,3-cyclohexadiene at 140℃; for 16h; Inert atmosphere;76%
4-phenyl-semicarbazide
537-47-3

4-phenyl-semicarbazide

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

A

C20H16BrClN4O

C20H16BrClN4O

B

C20H16BrClN4O

C20H16BrClN4O

Conditions
ConditionsYield
With hydrogenchloride In ethanol for 5h;A 35%
B 21%
...Expand
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

5-bromo-2-(2-bromo-acetylamino)-2'-chloro-benzophenone
32711-85-6

5-bromo-2-(2-bromo-acetylamino)-2'-chloro-benzophenone

Conditions
ConditionsYield
With pyridine
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

epichlorohydrin
106-89-8

epichlorohydrin

2-(3-chloro-2-hydroxy-propylamino)-5-bromo-2'-chloro-benzophenone
103380-05-8

2-(3-chloro-2-hydroxy-propylamino)-5-bromo-2'-chloro-benzophenone

Conditions
ConditionsYield
In acetic acid at 70℃; for 20h;26.5 g
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

4-Bromo-2-(2-chloro-benzoyl)-benzenediazonium; chloride

4-Bromo-2-(2-chloro-benzoyl)-benzenediazonium; chloride

Conditions
ConditionsYield
With hydrogenchloride; sodium nitrite In acetic acid at 1℃; for 0.5h;
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

5-Bromo-3-(2-chloro-phenyl)-1H-indazole

5-Bromo-3-(2-chloro-phenyl)-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aq. NaNO2, conc. HCl / acetic acid / 0.5 h / 1 °C
2: SnCl2*2H2O, conc. HCl / acetic acid / 0.5 h
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

5-Bromo-3-(2-chloro-phenyl)-1-[4-(4-phenyl-piperazin-1-yl)-butyl]-1H-indazole

5-Bromo-3-(2-chloro-phenyl)-1-[4-(4-phenyl-piperazin-1-yl)-butyl]-1H-indazole

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: aq. NaNO2, conc. HCl / acetic acid / 0.5 h / 1 °C
2: SnCl2*2H2O, conc. HCl / acetic acid / 0.5 h
3: KOH / toluene / 6 h / Heating
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

Trifluoro-acetic acid (2-amino-5-bromo-phenyl)-(2-chloro-phenyl)-methyl ester; compound with trifluoro-acetic acid

Trifluoro-acetic acid (2-amino-5-bromo-phenyl)-(2-chloro-phenyl)-methyl ester; compound with trifluoro-acetic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 96 percent / NaBH4 / H2O / 2 h / 25 - 30 °C
2: CHCl3 / 0.25 h / -20 - -18 °C
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

9b-(2'-chlorophenyl)-2,3,5,6,7,9b-hexahydro-8-bromo-5-methylbenzo(6,7)-4,1-oxazepine-(3,5)-oxolan
103380-07-0

9b-(2'-chlorophenyl)-2,3,5,6,7,9b-hexahydro-8-bromo-5-methylbenzo(6,7)-4,1-oxazepine-(3,5)-oxolan

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 26.5 g / acetic acid / 20 h / 70 °C
2: 19.0 g / formic acid; H2O / 2.5 h
3: 0.5 g / NH3 / methanol / 4 h / 120 - 130 °C
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

2-(3-chloro-2-hydroxy-1-methyl-propylamino)-5-bromo-2'-chloro-benzophenone
103380-06-9

2-(3-chloro-2-hydroxy-1-methyl-propylamino)-5-bromo-2'-chloro-benzophenone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 26.5 g / acetic acid / 20 h / 70 °C
2: 19.0 g / formic acid; H2O / 2.5 h
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

8-bromo-1-methyl-3-hydroxy-6-(2'-chlorophenyl)-1,2,3,4-tetrahydro-1,5-benzodiazocine
73591-00-1

8-bromo-1-methyl-3-hydroxy-6-(2'-chlorophenyl)-1,2,3,4-tetrahydro-1,5-benzodiazocine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 26.5 g / acetic acid / 20 h / 70 °C
2: 19.0 g / formic acid; H2O / 2.5 h
3: 10.4 g / NH3 / methanol / 4 h / 120 - 130 °C
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

8-bromo-5-(2-chlorophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine
87213-50-1

8-bromo-5-(2-chlorophenyl)-1-methyl-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97 percent / CHCl3 / 5 h / Heating
2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min.
3: 60 percent / P2S5 / pyridine / 0.75 h / Heating
4: 81 percent / butan-1-ol / 7 h / Heating
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

8-bromo-5-(2-chlorophenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine
87245-49-6

8-bromo-5-(2-chlorophenyl)-1-(methylthiomethyl)-4H-s-triazolo<4,3-a>-1,4-benzodiazepine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 97 percent / CHCl3 / 5 h / Heating
2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min.
3: 60 percent / P2S5 / pyridine / 0.75 h / Heating
4: 89 percent / butan-1-ol / 7 h / Heating
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione
87213-49-8

7-bromo-5-(2-chlorophenyl)-1,3-dihydro-1,4-benzodiazepin-2-thione

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 97 percent / CHCl3 / 5 h / Heating
2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min.
3: 60 percent / P2S5 / pyridine / 0.75 h / Heating
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

phenazepam
51753-57-2

phenazepam

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 97 percent / CHCl3 / 5 h / Heating
2: 90 percent / 18 percent aq. N2H4 / methanol / 1.) 60 deg C, 3 h, 2.) R.T. 30 min.
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

10-bromo-11b-(2-chloro-phenyl)-3-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
31758-95-9

10-bromo-11b-(2-chloro-phenyl)-3-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Py
2: (i) CH2Cl2, (ii) AcOH, EtOH
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

10-bromo-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
32711-04-9

10-bromo-11b-(2-chloro-phenyl)-7-methyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Py
2: (i) CH2Cl2, (ii) AcOH, EtOH
3: (i) NaOMe, MeOH, (ii) /BRN= 969135/, DMF
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

10-bromo-11b-(2-chloro-phenyl)-2,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
32969-62-3

10-bromo-11b-(2-chloro-phenyl)-2,7-dimethyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Py
2: (i) CH2Cl2, (ii) AcOH, EtOH
3: (i) NaOMe, MeOH, (ii) /BRN= 969135/, DMF
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

10-bromo-11b-(2-chloro-phenyl)-7-ethyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
32711-05-0

10-bromo-11b-(2-chloro-phenyl)-7-ethyl-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: Py
2: (i) CH2Cl2, (ii) AcOH, EtOH
3: (i) NaOMe, MeOH, (ii) (ethylation)
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

10-bromo-11b-(2-chloro-phenyl)-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one
24143-27-9

10-bromo-11b-(2-chloro-phenyl)-2,3,7,11b-tetrahydro-benzo[f]oxazolo[3,2-d][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Py
2: (i) CH2Cl2, (ii) AcOH, EtOH
View Scheme
(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

10-bromo-11b-(2-chloro-phenyl)-2-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one
24143-28-0

10-bromo-11b-(2-chloro-phenyl)-2-methyl-2,3,7,11b-hexahydro-benzo[f]oxazolo[3,2-e][1,4]diazepin-6-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Py
2: (i) CH2Cl2, (ii) AcOH, EtOH
View Scheme
2-Bromoacetyl bromide
598-21-0

2-Bromoacetyl bromide

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone
60773-49-1

(2-amino-5-bromophenyl)(2-chlorophenyl)methanone

phenazepam
51753-57-2

phenazepam

Conditions
ConditionsYield
Stage #1: 2-Bromoacetyl bromide; (2-amino-5-bromophenyl)(2-chlorophenyl)methanone With sodium hydrogencarbonate
Stage #2: With ammonia In methanol
Stage #1: 2-Bromoacetyl bromide; (2-amino-5-bromophenyl)(2-chlorophenyl)methanone With sodium hydrogencarbonate
Stage #2: With ammonia In methanol

2-Amino-5-bromine-2'-chloro benzophenone Chemical Properties

Molecular Structure of Methanone,(2-amino-5-bromophenyl)(2-chlorophenyl)- (CAS NO.60773-49-1):

Molecular Formula: C13H9BrClNO
Molecular Weight: 310.5737
IUPAC Name: (2-Amino-5-bromophenyl)-(2-chlorophenyl)methanone
Synonyms of Methanone,(2-amino-5-bromophenyl)(2-chlorophenyl)- (CAS NO.60773-49-1): 5-Bromo-2'-chloro-2-aminobenzophenone ; BCABP
CAS NO: 60773-49-1
Classification Code: Aromatic Benzophenones & Derivatives (substituted) 
Index of Refraction: 1.657
Molar Refractivity: 72.86 cm3
Molar Volume: 197.9 cm3
Surface Tension: 54.9 dyne/cm
Density: 1.568 g/cm3
Flash Point: 229.7 °C
Enthalpy of Vaporization: 71.61 kJ/mol
Boiling Point: 456.2 °C at 760 mmHg
Vapour Pressure of Methanone,(2-amino-5-bromophenyl)(2-chlorophenyl)- (CAS NO.60773-49-1): 1.65E-08 mmHg at 25°C

Related Products

Hot Products

Post buying leads

About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia

Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog

©2008 LookChem.com,License: ICP

NO.:Zhejiang16009103

complaints:service@lookchem.com Desktop View