Product Name

  • Name

    3,4-dihydro-2H-1,4-benzoxazin-6-ol

  • EINECS 247-415-5
  • CAS No. 26021-57-8
  • Article Data10
  • CAS DataBase
  • Density 1.241g/cm3
  • Solubility 19g/L at 20℃
  • Melting Point
  • Formula C8H9NO2
  • Boiling Point 334.7°Cat760mmHg
  • Molecular Weight 151.165
  • Flash Point 156.2°C
  • Transport Information
  • Appearance
  • Safety
  • Risk Codes
  • Molecular Structure Molecular Structure of 26021-57-8 (3,4-dihydro-2H-1,4-benzoxazin-6-ol)
  • Hazard Symbols
  • Synonyms 3,4-Dihydro-2H-1,4-benzoxazin-6-ol;3,4-Dihydro-2H-benzo-[b][1,4]oxazin-6-ol;3,4-Dihydro-2H-benzo[1,4]oxazin-6-ol;3,4-Dihydro-6-hydroxy-1,4(2H)-benzoxazine;6-Hydroxybenzomorpholine;6-Hydroxyphenomorpholine;
  • PSA 41.49000
  • LogP 1.33450

Synthetic route

6-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one
53412-38-7

6-hydroxy-3,4-dihydro-2H-1,4-benzoxazin-3-one

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 20℃;100%
With borane-THF In tetrahydrofuran at 5 - 20℃; for 24.5h; Inert atmosphere;95%
With borane-THF In tetrahydrofuran at 0 - 20℃; for 24.5h; Inert atmosphere;95%
2-((2,5-dimethoxyphenyl)amino)ethane-1-ol
28226-20-2

2-((2,5-dimethoxyphenyl)amino)ethane-1-ol

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
With SO42-/ZrO2-MnO2 In water at 110℃; for 4h; Reagent/catalyst;79.8%
With hydrogen bromide for 2h; cyclocondensation; demethylation; Heating;76%
6-methoxy-3,4-dihydro-2H-benzo[1,4]oxazine
58960-11-5

6-methoxy-3,4-dihydro-2H-benzo[1,4]oxazine

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
With boron tribromide In dichloromethane at -78 - 20℃; for 2h; Inert atmosphere;69%
2,5-dimethoxyaniline
102-56-7

2,5-dimethoxyaniline

CH2=CHCH2-halide

CH2=CHCH2-halide

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 41 percent / CaCO3 / H2O / 4 h / Heating
2: 76 percent / 62 percent HBr / 2 h / Heating
View Scheme
2-amino-4-methoxyphenol
20734-76-3

2-amino-4-methoxyphenol

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: potassium carbonate / acetonitrile / 10 h / 80 °C / Inert atmosphere
2: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
3: boron tribromide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere
View Scheme
6-methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one
5023-12-1

6-methoxy-2H-benzo[b][1,4]oxazin-3(4H)-one

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere
View Scheme
4-methoxy-2-nitrophenol
1568-70-3

4-methoxy-2-nitrophenol

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: ammonium chloride; iron / tetrahydrofuran; methanol; water / 4 h / 80 °C / Inert atmosphere
2: potassium carbonate / acetonitrile / 10 h / 80 °C / Inert atmosphere
3: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 0 - 20 °C / Inert atmosphere
4: boron tribromide / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere
View Scheme
2-chloro-N-(2',5'-dimethoxyphenyl)acetamide
22158-78-7

2-chloro-N-(2',5'-dimethoxyphenyl)acetamide

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: boron tribromide / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
2: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice
3: borane-THF / tetrahydrofuran / 24.5 h / 5 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 3 steps
1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere
3: borane-THF / tetrahydrofuran / 24.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
2,5-dimethoxyaniline
102-56-7

2,5-dimethoxyaniline

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: triethylamine / acetonitrile / 1 h / Inert atmosphere; Cooling with ice
2: boron tribromide / dichloromethane / 20 °C / Inert atmosphere; Cooling with ice
3: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice
4: borane-THF / tetrahydrofuran / 24.5 h / 5 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 4 steps
1: 1 h / 0 °C / Inert atmosphere
2: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere
3: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere
4: borane-THF / tetrahydrofuran / 24.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
2-chloro-N-(2,5-dihydroxyphenyl)acetamide
102580-34-7

2-chloro-N-(2,5-dihydroxyphenyl)acetamide

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere; Cooling with ice
2: borane-THF / tetrahydrofuran / 24.5 h / 5 - 20 °C / Inert atmosphere
View Scheme
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere
2: borane-THF / tetrahydrofuran / 24.5 h / 0 - 20 °C / Inert atmosphere
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

acetic anhydride
108-24-7

acetic anhydride

1-(6-hydroxy-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one
258524-47-9

1-(6-hydroxy-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one

Conditions
ConditionsYield
In water at 20℃; Sonication; Heating;95%
In water at 20 - 50℃; Sonication;95%
In water for 0.25h; Acetylation; Heating;65%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

tert-butyldimethylsilyl chloride
18162-48-6

tert-butyldimethylsilyl chloride

6-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-benzo[1,4]oxazine
1446001-82-6

6-(tert-butyl-dimethyl-silanyloxy)-3,4-dihydro-2H-benzo[1,4]oxazine

Conditions
ConditionsYield
Stage #1: 3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine With sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 0.333333h; Inert atmosphere;
Stage #2: tert-butyldimethylsilyl chloride In tetrahydrofuran; mineral oil for 1h; Time;		94%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

4-nitrobenzenediazonium tetrafluoroborate
456-27-9

4-nitrobenzenediazonium tetrafluoroborate

(E)-7-((4-nitrophenyl)diazenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol

(E)-7-((4-nitrophenyl)diazenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol

Conditions
ConditionsYield
Stage #1: 3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine With hydrogenchloride In methanol; water for 0.25h; Cooling with ice;
Stage #2: 4-nitrobenzenediazonium tetrafluoroborate In methanol; water at 0℃; for 1.25h;		87%
Stage #1: 3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine With hydrogenchloride In methanol; water at 0℃; for 0.25h;
Stage #2: 4-nitrobenzenediazonium tetrafluoroborate In methanol; water at 0℃; for 1.25h;		87%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

propionic acid anhydride
123-62-6

propionic acid anhydride

1-(6-hydroxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propan-1-one
258524-49-1

1-(6-hydroxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propan-1-one

Conditions
ConditionsYield
In water for 0.25h; Acylation; Heating;84%
butanoic acid anhydride
106-31-0

butanoic acid anhydride

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-(6-hydroxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-butan-1-one
258524-51-5

1-(6-hydroxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-butan-1-one

Conditions
ConditionsYield
In water for 0.25h; Acylation; Heating;79%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

benzoic acid anhydride
93-97-0

benzoic acid anhydride

4-benzoyl-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazine
258524-53-7

4-benzoyl-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
In ethyl acetate for 1h; Acylation; Heating;61%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

Chloroacetic anhydride
541-88-8

Chloroacetic anhydride

4-chloroacetyl-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazine
258524-57-1

4-chloroacetyl-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
In ethyl acetate Acylation; Heating;57%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

(E)-7-((4-nitrophenyl)diazenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol

(E)-7-((4-nitrophenyl)diazenyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol

3,8,9,10-tetrahydro-2H-bis([1,4]oxazino)[2,3-b:3,,2,-i]phenoxazin-4-ium

3,8,9,10-tetrahydro-2H-bis([1,4]oxazino)[2,3-b:3,,2,-i]phenoxazin-4-ium

Conditions
ConditionsYield
With perchloric acid In water; isopropyl alcohol at 80℃;55%
With perchloric acid In water; isopropyl alcohol at 80℃;55%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

5-ethylamino-4-methyl-2-nitrosophenol hydrochloride
63549-31-5

5-ethylamino-4-methyl-2-nitrosophenol hydrochloride

(Z)-N-(9-methyl-3,4-dihydro-[1,4]oxazino[2,3-b]phenoxazin-8(2H)-ylidene)ethanaminium

(Z)-N-(9-methyl-3,4-dihydro-[1,4]oxazino[2,3-b]phenoxazin-8(2H)-ylidene)ethanaminium

Conditions
ConditionsYield
With perchloric acid In water; isopropyl alcohol at 80℃;44%
With perchloric acid In water; isopropyl alcohol at 80℃;44%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

ethyl bromide
74-96-4

ethyl bromide

4-ethyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol
37171-41-8

4-ethyl-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-ol

Conditions
ConditionsYield
With potassium carbonate In N,N-dimethyl-formamide at 55℃; for 18h;38%
N,N-diethyl-3-methoxy-4-nitrosoaniline

N,N-diethyl-3-methoxy-4-nitrosoaniline

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

N-(3,4-dihydro-[1,4]oxazino[2,3-b]phenoxazin-8(2H)-ylidene)-N-ethylethanaminium

N-(3,4-dihydro-[1,4]oxazino[2,3-b]phenoxazin-8(2H)-ylidene)-N-ethylethanaminium

Conditions
ConditionsYield
With perchloric acid In water; isopropyl alcohol at 80℃;32%
With perchloric acid In water; isopropyl alcohol at 80℃;32%
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone
1025874-53-6

1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 65 percent / H2O / 0.25 h / Heating
2: 59 percent / K2CO3 / 3 h / 90 - 95 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

6-(3-isopropylamino-2-hydroxypropoxy)-3,4-dihydro-2H-1,4-benzoxazine

6-(3-isopropylamino-2-hydroxypropoxy)-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 65 percent / H2O / 0.25 h / Heating
2: 59 percent / K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
4: aq. KOH / methanol / 3 h / 65 - 70 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propan-1-one
1026846-85-4

1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-propan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 84 percent / H2O / 0.25 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

4-diethylaminoacetyl-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazine
258524-59-3

4-diethylaminoacetyl-6-hydroxy-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 57 percent / ethyl acetate / Heating
2: 63 percent / ethanol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

6-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydro-2H-1,4-benzoxazine

6-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 65 percent / H2O / 0.25 h / Heating
2: 59 percent / K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
4: aq. KOH / methanol / 3 h / 65 - 70 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-butan-1-one
1026918-15-9

1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-butan-1-one

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 79 percent / H2O / 0.25 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-ethanone
258524-70-8

1-[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / H2O / 0.25 h / Heating
2: 59 percent / K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-phenyl-methanone

(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-phenyl-methanone

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 61 percent / ethyl acetate / 1 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

4-acetyl-6-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-2H-1,4-benzoxazine
258524-75-3

4-acetyl-6-(3-tert-butylamino-2-hydroxy-propoxy)-3,4-dihydro-2H-1,4-benzoxazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 65 percent / H2O / 0.25 h / Heating
2: 59 percent / K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

2-diethylamino-1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone
1027928-97-7

2-diethylamino-1-(6-oxiranylmethoxy-2,3-dihydro-benzo[1,4]oxazin-4-yl)-ethanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 57 percent / ethyl acetate / Heating
2: 63 percent / ethanol / 3 h / Heating
3: K2CO3 / 3 h / 90 - 95 °C
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propan-1-one

1-[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / H2O / 0.25 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-[6-(3-tert-butylamino-2-hydroxy-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propan-1-one

1-[6-(3-tert-butylamino-2-hydroxy-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-propan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 84 percent / H2O / 0.25 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-butan-1-one

1-[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-butan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79 percent / H2O / 0.25 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

1-[6-(3-tert-butylamino-2-hydroxy-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-butan-1-one

1-[6-(3-tert-butylamino-2-hydroxy-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-butan-1-one

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 79 percent / H2O / 0.25 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme
3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine
26021-57-8

3,4-dihydro-6-hydroxy-1,4(2H)-benzoxazine

[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-phenyl-methanone

[6-(2-hydroxy-3-isopropylamino-propoxy)-2,3-dihydro-benzo[1,4]oxazin-4-yl]-phenyl-methanone

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 61 percent / ethyl acetate / 1 h / Heating
2: K2CO3 / 3 h / 90 - 95 °C
3: propan-2-ol / 3 h / Heating
View Scheme

2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- Chemical Properties

IUPAC Name: 3,4-Dihydro-2H-1,4-benzoxazin-6-ol
Synonyms of 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- (CAS NO.26021-57-8): 3,4-Dihydro-2H-1,4-benzoxazin-6-ol ; Hydroxybenzomorpholine ; EINECS 247-415-5
CAS NO: 26021-57-8
Molecular Formula of 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- (CAS NO.26021-57-8): C8H9NO2
Molecular Weight: 151.1626
Molecular Structure:

Polar Surface Area: 21.7 Å2
Index of Refraction: 1.582
Molar Refractivity: 40.65 cm3
Molar Volume: 121.7 cm3
Surface Tension: 51.3 dyne/cm
Density of 2H-1,4-Benzoxazin-6-ol, 3,4-dihydro- (CAS NO.26021-57-8): 1.241 g/cm3
Flash Point: 156.2 °C
Enthalpy of Vaporization: 60.06 kJ/mol
Boiling Point: 334.7 °C at 760 mmHg
Vapour Pressure: 6.46E-05 mmHg at 25°C

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