Product Name

  • Name

    3,3',4',5-TETRACHLOROSALICYLANILIDE

  • EINECS 214-576-8
  • CAS No. 1154-59-2
  • Article Data3
  • CAS DataBase
  • Density 1.636 g/cm3
  • Solubility
  • Melting Point 162ºC
  • Formula C13H7 Cl4 N O2
  • Boiling Point 408.1ºC at 760 mmHg
  • Molecular Weight 351.016
  • Flash Point 200.6 ºC
  • Transport Information
  • Appearance
  • Safety Poison by ingestion. A skin irritant. When heated to decomposition it emits very toxic fumes of Cl and NOx.
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 1154-59-2 (3,3',4',5-TETRACHLOROSALICYLANILIDE)
  • Hazard Symbols HarmfulXn
  • Synonyms Salicylanilide,3,3',4',5-tetrachloro- (6CI,7CI,8CI); 3,3',4',5-Tetrachlorosalicylanilide;3,5,3',4'-Tetrachlorosalicylanilide;3,5-Dichloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide; 3,5-Dichlorosalicylicacid 3,4-dichloroanilide; Impregon; Irgasan BS 200; Lenigron; WR 593
  • PSA 49.33000
  • LogP 5.33110

Synthetic route

3,5-dichlorosalicylic acid
320-72-9

3,5-dichlorosalicylic acid

m,p-dichloroaniline
95-76-1

m,p-dichloroaniline

3,3',4',5-tetrachlorosalicylanilide
1154-59-2

3,3',4',5-tetrachlorosalicylanilide

Conditions
ConditionsYield
With phosphorus trichloride In chlorobenzene for 3h; Heating;92%
3,5-dichloro-2-hydroxy-benzoyl chloride
39614-80-7

3,5-dichloro-2-hydroxy-benzoyl chloride

m,p-dichloroaniline
95-76-1

m,p-dichloroaniline

3,3',4',5-tetrachlorosalicylanilide
1154-59-2

3,3',4',5-tetrachlorosalicylanilide

Conditions
ConditionsYield
In 1,4-dioxane at 85℃; for 2h;
3,3',4',5-tetrachlorosalicylanilide
1154-59-2

3,3',4',5-tetrachlorosalicylanilide

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

6,8-dichloro-3-(3,4-dichloro-phenyl)-benzo[e][1,3]oxazine-2,4-dione
92030-30-3

6,8-dichloro-3-(3,4-dichloro-phenyl)-benzo[e][1,3]oxazine-2,4-dione

Conditions
ConditionsYield
In pyridine for 1h; Heating;62%
With pyridine In acetonitrile

3,3',4',5-Tetrachlorosalicylanilide Chemical Properties

IUPAC Name: 3,5-Dichloro-N-(3,4-dichlorophenyl)-2-hydroxybenzamide
Synonyms of 3,3',4',5-Tetrachlorosalicylanilide (CAS NO.1154-59-2) : Benzamide, 3,5-dichloro-N-(3,4-dichlorophenyl)-2-hydroxy- ; 3,3',4',5-Tetrachlorosalicylanilide ; 3,5,3',4'-Tetrachlorosalicylanilide
CAS NO: 1154-59-2
Molecular Formula :C13H7Cl4NO2
Molecular Weight :351.0122
Molecular Structure :
Index of Refraction: 1.693
Surface Tension: 63.4 dyne/cm
Density: 1.636 g/cm3
Flash Point: 200.6 °C
Enthalpy of Vaporization: 68.58 kJ/mol
Boiling Point: 408.1 °C at 760 mmHg
Vapour Pressure: 3.03E-07 mmHg at 25°C 
Melting point: 162 °C
Appearance: 3,3',4',5-Tetrachlorosalicylanilide (CAS NO.1154-59-2) is off-white to beige crystalline powder.

3,3',4',5-Tetrachlorosalicylanilide Uses

 3,3',4',5-Tetrachlorosalicylanilide (CAS NO.1154-59-2) is used as intermediate in organic synthesis .

3,3',4',5-Tetrachlorosalicylanilide Toxicity Data With Reference

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
rat LD50 oral 243mg/kg (243mg/kg)   Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 618, 1966.

 

3,3',4',5-Tetrachlorosalicylanilide Consensus Reports

Reported in EPA TSCA Inventory.

3,3',4',5-Tetrachlorosalicylanilide Safety Profile

Poison by ingestion. A skin irritant. When heated to decomposition it emits very toxic fumes of Cl and NOx.
Hazard CodesHarmfulXn
Risk Statements 22-36/37/38
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin.

3,3',4',5-Tetrachlorosalicylanilide Specification

General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam. 
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes. Avoid ingestion and inhalation.
Storage: Store in a cool, dry place. Store in a tightly closed container.

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