-
Name
3,4-Dimethoxy-2-pyridinemethanol
- EINECS
- CAS No. 72830-08-1
- Article Data10
- CAS DataBase
- Density 1.171 g/cm3
- Solubility
- Melting Point
- Formula C8H11NO3
- Boiling Point 275.516 °C at 760 mmHg
- Molecular Weight 169.18
- Flash Point 120.428 °C
- Transport Information
- Appearance
- Safety
- Risk Codes
-
Molecular Structure
-
Hazard Symbols
Xi
- Synonyms 2-Hydroxymethyl-3,4-dimethoxypyridine;3,4-Dimethoxy-2-(hydroxymethyl)pyridine;
- PSA 51.58000
- LogP 0.59110
Synthetic route
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72830-07-0
3,4-dimethoxy-2-methylpyridine N-oxide
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| With acetic anhydride for 4h; Reflux; | 91% |
| Stage #1: 3,4-dimethoxy-2-methylpyridine N-oxide With acetic anhydride at 90℃; for 2h; Stage #2: With sodium hydroxide In water at 80℃; for 2h; | 76% |
| Multi-step reaction with 2 steps 1: 4 h / 100 °C 2: 2 M NaOH / 1 h / 100 °C View Scheme | |
| Multi-step reaction with 2 steps 1: 2 h / 90 °C 2: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
| Multi-step reaction with 2 steps 1: AcOH / 120 °C 2: 2N aq. NaOH / methanol / 2 h / 25 °C View Scheme |
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102625-99-0
2-acetoxymethyl-3,4-dimethoxypyridine
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| With sodium hydroxide at 80℃; for 2h; Yield given; | |
| With sodium hydroxide In methanol at 25℃; for 2h; | |
| With sodium hydroxide at 100℃; for 1h; | |
| With sodium hydroxide In Petroleum ether | |
| With sodium hydroxide In Petroleum ether |
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118-71-8
Maltol
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 7 steps 1: 68 percent / K2CO3 / acetone / 19 h / Heating 2: 77 percent / conc. ammonia / 3 h / 110 °C 3: 85 percent / POCl3 / 10 h / Heating 4: NaOMe / 10 h / Heating 5: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 6: 4 h / 100 °C 7: 2 M NaOH / 1 h / 100 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: ammonium hydroxide / 2 h / 40 °C 1.2: 10 h / 40 °C / Reflux 2.1: potassium hydroxide / water / 20 h / 10 - 20 °C 3.1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C 4.1: acetic anhydride / 4 h / Reflux View Scheme |
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4780-14-7
3-methoxy-2-methyl-4-pyrone
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 6 steps 1: 77 percent / conc. ammonia / 3 h / 110 °C 2: 85 percent / POCl3 / 10 h / Heating 3: NaOMe / 10 h / Heating 4: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 5: 4 h / 100 °C 6: 2 M NaOH / 1 h / 100 °C View Scheme |
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76015-11-7
2-methyl-3-methoxy-4(1H)-pyridinone
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 5 steps 1: 85 percent / POCl3 / 10 h / Heating 2: NaOMe / 10 h / Heating 3: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 4: 4 h / 100 °C 5: 2 M NaOH / 1 h / 100 °C View Scheme | |
| Multi-step reaction with 5 steps 1: 96 percent / POCl3 / 18 h / 90 °C 2: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 3: 91 percent / NaOMe / 18 h 4: 2 h / 90 °C 5: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
| Multi-step reaction with 4 steps 1.1: trichlorophosphate / 18 h / 90 °C / Inert atmosphere 2.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C 3.1: methanol / 16 h / 40 °C 4.1: acetic anhydride / 2 h / 90 °C 4.2: 2 h / 80 °C View Scheme |
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107512-34-5
4-Chloro-3-methoxy-2-methyl-pyridine
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: NaOMe / 10 h / Heating 2: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 3: 4 h / 100 °C 4: 2 M NaOH / 1 h / 100 °C View Scheme | |
| Multi-step reaction with 4 steps 1: 90 percent / 30percent aq. H2O2, AcOH / 24 h / 90 °C 2: 91 percent / NaOMe / 18 h 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: acetic acid; dihydrogen peroxide / water / 24 h / 90 °C 2.1: methanol / 16 h / 40 °C 3.1: acetic anhydride / 2 h / 90 °C 3.2: 2 h / 80 °C View Scheme |
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107512-35-6
3,4-dimethoxy-2-methylpyridine
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 98 percent / 84percent m-CPBA / CH2Cl2 / 4 h / Ambient temperature 2: 4 h / 100 °C 3: 2 M NaOH / 1 h / 100 °C View Scheme | |
| Multi-step reaction with 2 steps 1: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C 2: acetic anhydride / 4 h / Reflux View Scheme |
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15931-25-6
3-methoxy-2-methyl-4-nitropyridine 1-oxide
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 88 percent / NaOMe / 16 h / 40 °C 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C View Scheme |
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35392-65-5
3-methoxy-2-methylpyridine 1-oxide
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 58 percent / 98percent HNO3 / acetic acid / 33 h / 80 °C 2: 88 percent / NaOMe / 16 h / 40 °C 3: 2 h / 90 °C 4: 2 N aq. NaOH / 2 h / 80 °C View Scheme |
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122307-41-9
4-chloro-3-methoxy-2-methylpyridine N-oxide
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 91 percent / NaOMe / 18 h 2: 2 h / 90 °C 3: 2 N aq. NaOH / 2 h / 80 °C View Scheme | |
| Multi-step reaction with 2 steps 1.1: methanol / 16 h / 40 °C 2.1: acetic anhydride / 2 h / 90 °C 2.2: 2 h / 80 °C View Scheme |
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15931-17-6
3-fluoro-2-methyl-4-nitropyridine 1-oxide
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| In acetic anhydride |
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102625-70-7
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
-
B
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| With water at 40℃; for 5844h; |
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108-24-7
acetic anhydride
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72830-07-0
3,4-dimethoxy-2-methylpyridine N-oxide
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64-19-7
acetic acid
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Stage #1: 3,4-dimethoxy-2-methylpyridine N-oxide ; acetic acid at 75℃; Large scale; Stage #2: acetic anhydride at 80 - 85℃; under 690.069 Torr; for 16h; Large scale; Stage #3: With sodium hydroxide at 18 - 55℃; for 2h; pH=12 - 13; Temperature; Large scale; |
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17184-19-9
3-hydroxy-2-methylpyrid-4-one
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: potassium hydroxide / water / 20 h / 10 - 20 °C 2: acetic acid; sodium tungstate; dihydrogen peroxide / 4 h / 40 - 95 °C 3: acetic anhydride / 4 h / Reflux View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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72830-09-2
2-Chloromethyl-3,4-dimethoxy-pyridine; hydrochloride
| Conditions | Yield |
|---|---|
| With thionyl chloride In dichloromethane for 2h; | 100% |
| With bis(trichloromethyl) carbonate; Triphenylphosphine oxide In toluene at 20 - 60℃; for 4h; | 98% |
| With thionyl chloride In dichloromethane at 0 - 5℃; for 2h; | 93% |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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169905-10-6
2-(chloromethyl)-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| With thionyl chloride In dichloromethane | 88% |
| With thionyl chloride In dichloromethane | 88% |
| With thionyl chloride In dichloromethane at 25℃; for 2h; |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 100 percent / SOCl2 / CH2Cl2 / 2 h 2: 1.) aq. NaOH / methanol View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 100 percent / SOCl2 / CH2Cl2 / 2 h 2: 1.) aq. NaOH / methanol 3: m-CPBA, aq. NaHCO3 / CH2Cl2 / 0.17 h View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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102625-64-9
pantoprazole sulfide
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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138786-84-2
5-Difluoromethoxy-2-(3,4-dimethoxy-pyridin-2-ylmethylsulfanyl)-6-fluoro-1H-benzoimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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102625-65-0
5-difluoromethoxy-6-methoxy-2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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102625-75-2
2,2-difluoro-6-[(3,4-dimethoxy-2-pyridyl)methylthio]-5H-[1,3]-dioxolo-[4,5-f]benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: aq. NaOH / ethanol / 4 h / 60 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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102625-70-7
5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridyl)methyl]sulfinyl]-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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102625-63-8
2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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138786-82-0
2-[(3,4-dimethoxy-pyridin-2-yl)methylthio]-5-(2,2,2-trifluoroethoxy)-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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102625-81-0
6-(3,4-Dimethoxy-pyridin-2-ylmethanesulfinyl)-2,2-difluoro-5H-[1,3]dioxolo[4',5':4,5]benzo[1,2-d]imidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: aq. NaOH / ethanol / 4 h / 60 °C 3: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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-
138786-72-8
5-Difluoromethoxy-2-(3,4-dimethoxy-pyridin-2-ylmethanesulfinyl)-6-fluoro-1H-benzoimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 73 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
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72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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-
138786-71-7
5-difluoromethoxy-6-methoxy-2-[(3,4-dimethoxy-pyridin-2-yl)methylsulfinyl]-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 83 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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-
102625-69-4
2-[(3,4-dimethoxy-pyridin-2-yl)methylsulfinyl]-5-(1,1,2,2-tetrafluoroethoxy)-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 66 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
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-
138786-69-3
2-[(3,4-dimethoxy-pyridin-2-yl)methylsulfinyl]-5-(2,2,2-trifluoroethoxy)-1H-benzimidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 87 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C View Scheme |
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
-
-
138786-75-1
9-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C 4: aq. hexafluorophosphoric acid / methanol / 1.5 h / 0 - 5 °C View Scheme |
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
-
-
138786-76-2
10-(difluoromethoxy)-3,4-dimethoxy-5H-pyrido<1',2':4,5><1,2,4>thiadiazino<2,3-a>benzimidazol-13-ium hexafluorophosphate
| Conditions | Yield |
|---|---|
| Multi-step reaction with 4 steps 1: 93 percent / SOCl2 / CH2Cl2 / 2 h / 0 - 5 °C 2: 2 N aq. NaOH / ethanol / 2 h / 50 °C 3: 85 percent / m-chloroperbenzoic acid / CH2Cl2 / 0.5 h / -30 °C 4: aq. hexafluorophosphoric acid / methanol / 1.5 h / 0 - 5 °C View Scheme |
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
-
-
122307-42-0
2-(3,4-Dimethoxy-pyridin-2-ylmethylsulfanyl)-1H-thieno[3,4-d]imidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: SOCl2 / CH2Cl2 / 2 h / 25 °C 2: 27 percent / NaOMe / methanol / 1 h / 65 °C View Scheme |
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-
72830-08-1
2-hydroxymethyl-3,4-dimethoxypyridine
-
-
122307-43-1
2-(3,4-Dimethoxy-pyridin-2-ylmethanesulfinyl)-1H-thieno[3,4-d]imidazole
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1: SOCl2 / CH2Cl2 / 2 h / 25 °C 2: 27 percent / NaOMe / methanol / 1 h / 65 °C 3: 60 percent / aq. sodium bicarbonate, m-chloroperbenzoic acid / CH2Cl2 / 0.17 h / 0 °C View Scheme |
3,4-Dimethoxy-2-pyridinemethanol Chemical Properties
Product Name: 3,4-Dimethoxy-2-pyridinemethanol
Molecular Structure:
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Molecular Formula: C8H11NO3
Molecular Weight: 169.1778
Synonyms of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 4-Chloro-2-chloromethyl-3-methoxypyridine hydrochloride ; 4-Chloro-2-chloromethyl-3-methoxypyridine,hydrochloride salt ; 4-Chloro-3-methoxy-2-chloromethylpyridine hcl ; 4-Chloro-3-methoxy-2-chloromethyl pyridine hydrochloride ; 2-Hydroxymethyl-3,4-dimethoxypyridine
CAS NO: 72830-08-1
Product Categories: Pyridines, Pyrimidines, Purines and Pteredines ; Pyridines derivates ; API intermediates
H bond acceptors: 4
H bond donors: 1
Freely Rotating Bonds: 4
Polar Surface Area: 51.58 Å2
Index of Refraction: 1.523
Molar Refractivity: 44.152 cm3
Molar Volume: 144.478 cm3
Surface Tension: 42.229 dyne/cm
Density: 1.171 g/cm3
Flash Point: 120.428 °C
Enthalpy of Vaporization: 54.292 kJ/mol
Boiling Point: 275.516 °C at 760 mmHg
Vapour Pressure of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 0.002 mmHg at 25°C
3,4-Dimethoxy-2-pyridinemethanol Safety Profile
Hazard Codes of 3,4-Dimethoxy-2-pyridinemethanol (CAS NO.72830-08-1): 
Xi
Hazard Note: Irritant
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