3,5,6-Trichloro-2-pyridinol supplier

Name
3,5,6-Trichloro-2-pyridinol
EINECS 229-405-2
CAS No. 6515-38-4
Article Data33
CAS DataBase
Density 1.67 g/cm³
Solubility 0.22g/L(temperature not stated)
Melting Point 328-330 °C
Formula C₅H₂Cl₃NO
Boiling Point 254.8 °C at 760 mmHg
Molecular Weight 198.436
Flash Point 107.9 °C
Transport Information UN 3077
Appearance powder
Safety 26-39-61
Risk Codes 22-41-51/53
Molecular Structure
Hazard Symbols Xn, N
Synonyms 2(1H)-Pyridone,3,5,6-trichloro- (8CI);2-Pyridinol, 3,5,6-trichloro- (7CI);2,3,5-Trichloro-6-hydroxypyridine;2-Hydroxy-3,5,6-trichloropyridine;2-Hydroxyl-3,5,6-trichloropyridine;3,5,6-Trichloro-2-hydroxypyridine;3,5,6-Trichloro-2-pyridinol;3,5,6-Trichloropyridine-2-ol;
PSA 32.86000
LogP 2.33510

Synthetic route

: 3,3,5,6-tetrachloro-1,2,3,4-tetrahydropyridin-2-one

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With sodium hydroxide In 1,2-dichloro-ethane at 25℃; for 20h;	100%

: sodium salt of 3,5,6-trichloropyridine-2-ol

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With hydrogenchloride In water at 60 - 70℃; for 0.166667h; pH=2 - 3;	97.75%

: 2921-88-2
Chlorpyrifos

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With potassium hydroxide In ethanol for 4h; Heating;	91.7%
With potassium hydroxide In ethanol for 1h; Heating;	90%
With water at 40℃; for 960h; Rate constant; Thermodynamic data; E(a); other natural water, pH = 8.0;

: 2402-79-1
2,3,5,6-tetrachloropyridine

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With potassium hydroxide In tert-butyl alcohol for 10h; Heating;	88%
With tetrabutylammomium bromide; sodium hydroxide In water at 100℃; for 8h; Inert atmosphere;	87%
Stage #1: 2,3,5,6-tetrachloropyridine With potassium hydroxide In water at 95℃; for 0.5h; pH=9.5 - 10; Stage #2: With benzyltrimethylammonium chloride In water at 120℃; for 4h; Reagent/catalyst; Temperature; Autoclave;	35.9 g

: 107-13-1
acrylonitrile

: 76-02-8
Trichloroacetyl chloride

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
Stage #1: acrylonitrile; trifluoroacetyl chloride With copper(l) chloride at 120 - 150℃; under 1140.08 - 4560.31 Torr; for 6h; Stage #2: With water; sodium hydroxide at 30 - 150℃; under 1520.1 Torr;	61%

: 16879-02-0
6-chloro-2-hydroxypyridine

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With hydrogenchloride; water; dihydrogen peroxide

: 856850-90-3
2-ethoxy-6-bromo-3,5-dichloro-pyridine

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With hydrogenchloride; water at 160℃; Unter Druck;

: 5598-13-0
O,O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With sodium phosphate buffer; hydrogen sulfide; sodium chloride In methanol at 25℃; pH=5.9; Kinetics; Further Variations:; pH-values; var. hydrogen sulfide concentration;
With C54H36N6NiO10S2 In aq. phosphate buffer at 30℃; for 0.833333h;

: 5598-52-7
Fospirate

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 813-78-5
dimethylphosphoric acid

Conditions

Conditions	Yield
With bacterial phosphotriesterase wild-type OpdA In methanol at 37℃; pH=8.5; Enzyme kinetics;
With air In acetonitrile for 3.91667h; Kinetics; Solvent; UV-irradiation;

: 5598-13-0
O,O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 1112-38-5
dimethylthiophosphoric acid

Conditions

Conditions	Yield
With bacterial phosphotriesterase wild-type OpdA In methanol at 37℃; pH=8.5; Enzyme kinetics;
With water; sodium hydroxide In acetonitrile at 25℃; for 6h; Kinetics; Mechanism; Equilibrium constant; Solvent; Concentration; Reagent/catalyst; pH-value;

: 133206-32-3
4-cyano-2,2,4-trichlorobutanoyl chloride

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 97 percent / HCl / ethyl acetate / 2 h / 25 °C / 5171.5 Torr 2: 100 percent / aq. NaOH / 1,2-dichloro-ethane / 20 h / 25 °C View Scheme

: 4645-11-8
6-ethoxy-2-bromo-pyridine

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: water; hydrochloric acid / 160 °C / Unter Druck 2: hydrogen peroxide; water; hydrochloric acid View Scheme
Multi-step reaction with 2 steps 1: acetic acid; hydrogen peroxide; water; hydrochloric acid 2: water; hydrochloric acid / 160 °C / Unter Druck View Scheme

: 3,5,6-trichloropyrid-2-yl trichloroacetate

: 107-13-1
acrylonitrile

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: sodium salt of 3,5,6-trichloropyridine-2-ol

Conditions

Conditions	Yield
With hydrogenchloride; copper(I) chloride In sulfolane

...Expand

: 126767-79-1
phenyl 4-cyano-2,2,4-trichlorobutyrate

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With hydrogenchloride; sodium carbonate In sulfolane
In sulfolane; acetonitrile

: 107-13-1
acrylonitrile

: 76-02-8
Trichloroacetyl chloride

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 2402-79-1
2,3,5,6-tetrachloropyridine

Conditions

Conditions	Yield
copper(I) chloride In acetonitrile
Stage #1: acrylonitrile; trifluoroacetyl chloride With copper(l) chloride at 80 - 130℃; under 760.051 Torr; for 32h; Inert atmosphere; Stage #2: at 110 - 130℃; under 760.051 Torr; for 8h; Stage #3: With water; sodium hydroxide at 30 - 40℃; Overall yield = 55 %;	A 141 g B 84 g
With copper(l) chloride under 2660.18 - 4560.31 Torr; for 5h; Thermodynamic data; Autoclave; Heating;	A 1.9 g B 1.64 g

...Expand

: chlorpyrifos

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With bromine In water at 25℃; Kinetics; Reagent/catalyst; pH-value;

: 5598-15-2
chlopyrifos oxon

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With wild type methyl parathion hydrolase; sodium chloride; zinc(II) chloride In aq. buffer at 30℃; pH=7.6; Kinetics; Reagent/catalyst; Enzymatic reaction;
With hydrogenchloride; water; C15H21INO9PolSi at 25℃; for 0.00833333h; pH=7.4; Rate constant;
With sodium hydroxide In aq. buffer at 23℃; for 1.71667h; pH=11.8; Kinetics;

: 2921-88-2
Chlorpyrifos

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 2465-65-8
O,O'-diethyl thiophosphoric acid

Conditions

Conditions	Yield
With water

: 107-13-1
acrylonitrile

: 76-02-8
Trichloroacetyl chloride

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 2402-79-1
2,3,5,6-tetrachloropyridine

C: 79204-46-9
3,3,5-trichloropiperidine-2,6-dione

D: 1617-17-0
2-chlorpropionitrile

E: 3,3,5,6-tetrachloro-1,2,3,4-tetrahydropyridin-2-one

Conditions

Conditions	Yield
With copper(l) chloride at 120 - 150℃; under 1140.08 - 4560.31 Torr; for 6h; Overall yield = 182 g;	A 22 %Spectr. B 22 %Spectr. C 13 %Spectr. D 22 %Spectr. E 21 %Spectr.
Stage #1: acrylonitrile; trifluoroacetyl chloride With copper(l) chloride at 80 - 130℃; under 760.051 Torr; for 32h; Inert atmosphere; Stage #2: at 110 - 130℃; under 760.051 Torr; for 8h;	A 5 %Spectr. B 17 %Spectr. C 20 %Spectr. D 6 %Spectr. E 40 %Spectr.

...Expand

: 107-13-1
acrylonitrile

: 76-02-8
Trichloroacetyl chloride

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 2402-79-1
2,3,5,6-tetrachloropyridine

C: 79204-46-9
3,3,5-trichloropiperidine-2,6-dione

D: 1617-17-0
2-chlorpropionitrile

Conditions

Conditions	Yield
With copper(l) chloride at 150℃; under 4560.31 Torr; for 5h;	A 29 %Spectr. B 26 %Spectr. C 16 %Spectr. D 26 %Spectr.

...Expand

: 2921-88-2
Chlorpyrifos

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 5598-15-2
chlopyrifos oxon

C: 762-04-9
phosphonic acid diethyl ester

Conditions

Conditions	Yield
With titanium(IV) dioxide In water; acetonitrile at 25℃; for 0.5h; Concentration; Irradiation;

...Expand

: 2921-88-2
Chlorpyrifos

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 5598-15-2
chlopyrifos oxon

C: O,O-dihydrogen phosphorothioite

D: H2O3P(1-)

E: O-ethyl O-(3,5,6-trichloropyridin-2-yl)-O-hydrogenphosphorothioate

F: ethyl (3,5,6-trichloropyridin-2-yl)-O-hydrogenphosphate

G: 3,5,6-trichloropyridin-2-yl dihydrogen phosphate

H: O-(3,5,6-trichloropyridin-2-yl) O,O-dihydrogenphosphorothioate

Conditions

Conditions	Yield
With sodium hydroxide at 25℃; pH=5.8; Kinetics; Catalytic behavior; UV-irradiation; Green chemistry;

...Expand

: 5598-52-7
Fospirate

: 6515-38-4
3,5,6-trichloropyridin-2 ol

Conditions

Conditions	Yield
With wild type methyl parathion hydrolase; sodium chloride; zinc(II) chloride In aq. buffer at 30℃; pH=7.6; Kinetics; Reagent/catalyst; Enzymatic reaction;

: 5598-13-0
O,O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate

A: 6515-38-4
3,5,6-trichloropyridin-2 ol

B: 5598-52-7
Fospirate

C: 813-78-5
dimethylphosphoric acid

D: 1112-38-5
dimethylthiophosphoric acid

Conditions

Conditions	Yield
With air In acetonitrile for 3.91667h; Kinetics; Reagent/catalyst; Solvent; UV-irradiation;

...Expand

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: tris-(3,5,6-trichloropyridin-2-yl) phosphite

Conditions

Conditions	Yield
Stage #1: 3,5,6-trichloropyridin-2 ol In toluene at 105 - 115℃; for 2h; Stage #2: With dmap; phosphorus trichloride at 35 - 75℃; for 2.5h; Reagent/catalyst;	97.49%

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 5437-33-2
3,5-Dichloro-2-pyridinol

Conditions

Conditions	Yield
With acetic acid; zinc In water at 60℃; for 8h; Concentration; Reagent/catalyst; Temperature;	86.5%

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 105-39-5
chloroacetic acid ethyl ester

: 60825-27-6
ethyl 2-((3,5,6-trichloropyridin-2-yl)oxy)acetate

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;	83.2%

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 133409-72-0
methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate

: methyl (E)-2-(methoxyimino)-2-(2-(((3,5,6-trichloropyridin-2-yl)oxy)methyl)phenyl)acetate

Conditions

Conditions	Yield
Stage #1: 3,5,6-trichloropyridin-2 ol With potassium carbonate In butanone for 0.5h; Stage #2: methyl (E)-2-[2-(bromomethyl)phenyl]-2-(methoxyimino)acetate In butanone at 80℃; for 5h;	74.1%

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 24528-09-4
O,O-Diethyl o-vinyl phosphite

: O-Ethyl O-(3,5,6-trichloro-2-pyridinyl) O-vinyl phosphate

Conditions

Conditions	Yield
Stage #1: O,O-Diethyl o-vinyl phosphite With iodine In dichloromethane at 20℃; for 0.0833333h; Oxidation; Stage #2: 3,5,6-trichloropyridin-2 ol With triethylamine In dichloromethane at 20℃; for 0.166667h; Substitution;	73%

: 117428-51-0
methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: methyl (E)-3-methoxy-2-(2-(((3,5,6-trichloropyridin-2-yl)oxy)methyl)phenyl)acrylate

Conditions

Conditions	Yield
Stage #1: 3,5,6-trichloropyridin-2 ol With potassium carbonate In N,N-dimethyl-formamide for 0.5h; Stage #2: methyl (E)-3-methoxy-2-(2-chloromethylphenyl)acrylate In N,N-dimethyl-formamide at 80℃; for 3h;	72.8%

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 1498-64-2
O-ethyl dichlorothiophosphate

: 76395-14-7
thiophosphorochloridic acid O-ethyl O'-(3,5,6-trichloropyridin-2-yl) ester

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 1h;	43%
With triethylamine In tetrahydrofuran for 2h;	30%
With triethylamine In benzene

: 623-73-4
diazoacetic acid ethyl ester

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 55335-06-3
triclopyr acid

Conditions

Conditions	Yield
at 165℃; Erwaermen des Reaktionsprodukts mit wss.-aethanol.Natronlauge;

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 2402-79-1
2,3,5,6-tetrachloropyridine

Conditions

Conditions	Yield
With phosphorus pentachloride; trichlorophosphate at 180℃;

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: phosphoriodidic acid divinyl ester

: O,O-Divinyl O-(3,5,6-trichloro-2-pyridinyl) phosphate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 0.166667h; Substitution;

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: phosphoriodidic acid ethyl ester vinyl ester

: O-Ethyl O-(3,5,6-trichloro-2-pyridinyl) O-vinyl phosphate

Conditions

Conditions	Yield
With pyridine In dichloromethane at 20℃; for 0.166667h; Substitution;

: 151827-83-7
methyl N-(2-bromomethylphenyl)-N-methoxy-carbamate

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 902760-40-1
methyl N-methoxy-N-[2-[[(3,5,6-trichloropyridin-2-yl)oxo]methyl]phenyl]carbamate

Conditions

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 6h;

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: (3-hydroxypropyl)thiophosphoramidic acid O-ethyl O'-(3,5,6-trichloropyridin-2-yl) ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 43 percent / K2CO3 / acetonitrile / 1 h / 20 °C 2: 54 percent / NaHCO3 / acetonitrile / 4 °C View Scheme

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: [ethyl-1,2-3H]chlorpyrifos oxon

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: I2 / CH2Cl2 / 0.08 h / 20 °C 1.2: 73 percent / triethylamine / CH2Cl2 / 0.17 h / 20 °C 2.1: tritium gas / Pd/C / ethyl acetate / 3 h / 720 Torr View Scheme

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 4-[Ethoxy-(3,5,6-trichloro-pyridin-2-yloxy)-thiophosphoryloxy]-butyric acid

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: 30 percent / triethylamine / tetrahydrofuran / 2 h 2: 12 percent / triethylamine / tetrahydrofuran / 24 h / Ambient temperature 3: 71 percent / HBr, AcOH / 1 h View Scheme

: 6515-38-4
3,5,6-trichloropyridin-2 ol

: 182170-91-8
4-[Ethoxy-(3,5,6-trichloro-pyridin-2-yloxy)-thiophosphoryloxy]-butyric acid benzyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 30 percent / triethylamine / tetrahydrofuran / 2 h 2: 12 percent / triethylamine / tetrahydrofuran / 24 h / Ambient temperature View Scheme

3,5,6-Trichloro-2-pyridinol Chemical Properties

IUPAC Name: 3,5,6-Trichloro-2-pyridinol
The MF of 3,5,6-Trichloro-2-pyridinol (6515-38-4) is C₅H₂Cl₃NO.

The MW of 3,5,6-Trichloro-2-pyridinol (6515-38-4) is 198.43.
Synonyms of 3,5,6-Trichloro-2-pyridinol (6515-38-4): 2(1H)-Pyridinone, 3,5,6-trichloro- ; 2-Pyridinol, 3,5,6-trichloro- ; 3,5,6-Trichloro-2-hydroxypyridine ; 3,5,6-Trichloro-2-pyridinol ; 3,5,6-Trichloropyridin-2-ol ; Chlorpyrifos metabolite
Product Categories: Pyridines;Q-ZAlphabetic;TP - TZ;Alpha sort;Environmental Standards;MetabolitesPesticides&Metabolites;Pesticides&Metabolites
Stability: Stable. Incompatible with strong oxidizing agents
Index of Refraction: 1.598
EINECS: 229-405-2
Density: 1.67 g/ml
Flash Point: 107.9 °C
Boiling Point: 254.8 °C
Melting Point: 328-330°C
Form: powder

3,5,6-Trichloro-2-pyridinol Uses

3,5,6-Trichloro-2-pyridinol (6515-38-4) is used as PVC and three acetate (film film film-based) and other plasticizers.

3,5,6-Trichloro-2-pyridinol Toxicity Data With Reference

1.		orl-rat LD50:800 mg/kg		TOSCF2 Toxicological Sciences 53 (2000),100.
2.		skn-rbt LD50:>2 g/kg		TOSCF2 Toxicological Sciences 53 (2000),100.

3,5,6-Trichloro-2-pyridinol Safety Profile

Moderately toxic by ingestion and skin contact. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NO_x and Cl⁻.
Safety information of 3,5,6-Trichloro-2-pyridinol (6515-38-4):
Hazard Codes Xn;N
Risk Statements
22 Harmful if swallowed
41 Risk of serious damage to eyes
51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Safety Statements
26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39 Wear eye/face protection
61 Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR UN 3077
RTECS UU7786700

Product Name

3,5,6-Trichloro-2-pyridinol

Synthetic route

3,5,6-Trichloro-2-pyridinol Chemical Properties

3,5,6-Trichloro-2-pyridinol Uses

3,5,6-Trichloro-2-pyridinol Toxicity Data With Reference

3,5,6-Trichloro-2-pyridinol Safety Profile

Related Products

Hot Products