Product Name

  • Name

    4-(2,4-DICHLOROPHENOXY)PHENOL

  • EINECS 255-106-1
  • CAS No. 40843-73-0
  • Article Data5
  • CAS DataBase
  • Density 1.398g/cm3
  • Solubility
  • Melting Point
  • Formula C12H8Cl2O2
  • Boiling Point 354°C at 760mmHg
  • Molecular Weight 255.1
  • Flash Point 167.9°C
  • Transport Information
  • Appearance
  • Safety 60-61
  • Risk Codes 22
  • Molecular Structure Molecular Structure of 40843-73-0 (4-(2,4-DICHLOROPHENOXY)PHENOL)
  • Hazard Symbols Xn,N
  • Synonyms 4-(2,4-Dichlorophenoxy)phenol;4-(2',4'-Dichlorophenoxy)phenol;p-(2,4-Dichlorophenoxy)phenol;
  • PSA 29.46000
  • LogP 4.49130

Synthetic route

C12H7Cl2N2O(1+)*BF4(1-)

C12H7Cl2N2O(1+)*BF4(1-)

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

Conditions
ConditionsYield
(i) Ac2O, (ii) aq. NaOH, MeOH; Multistep reaction;
1-bromo-2,4-dichlorobenzene
1193-72-2

1-bromo-2,4-dichlorobenzene

phenol
108-95-2

phenol

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

Conditions
ConditionsYield
Yield given. Multistep reaction;
2,4-dichloro-4'-aminodiphenyl ether
14861-17-7

2,4-dichloro-4'-aminodiphenyl ether

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: (i) aq. HCl, AcOH, (ii) NaNO2, aq. HBF4
2: (i) Ac2O, (ii) aq. NaOH, MeOH
View Scheme
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

(R,S)-2-chloropropionic acid
598-78-7

(R,S)-2-chloropropionic acid

diclofop
40843-25-2

diclofop

Conditions
ConditionsYield
With sodium hydroxide; phosphoric acid In 5,5-dimethyl-1,3-cyclohexadiene; water99.5%
Methyl 2-bromopropionate
5445-17-0

Methyl 2-bromopropionate

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

diclofop-methyl
51338-27-3

diclofop-methyl

Conditions
ConditionsYield
With potassium carbonate In acetone for 20h; Heating;94%
ethyl (E)-4-bromopent-2-enoate
53662-67-2

ethyl (E)-4-bromopent-2-enoate

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

Ethyl 4-[4(2,4-dichlorophenoxy)phenoxy](2)-pentenoate
72281-60-8

Ethyl 4-[4(2,4-dichlorophenoxy)phenoxy](2)-pentenoate

Conditions
ConditionsYield
With sodium carbonate In N-methyl-acetamide85.2%
3,5-dichloro-4-(3-bromopropyloxy)-1-(3,3-dichloro-2-propenyloxy)benzene
178043-45-3

3,5-dichloro-4-(3-bromopropyloxy)-1-(3,3-dichloro-2-propenyloxy)benzene

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

1,3-dichloro-5-((3,3-dichloroallyl)oxy)-2-(3-(4-(2,4-dichlorophenoxy)phenoxy)propoxy)benzene

1,3-dichloro-5-((3,3-dichloroallyl)oxy)-2-(3-(4-(2,4-dichlorophenoxy)phenoxy)propoxy)benzene

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 1h; Reflux;83%
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate
57057-80-4

ethyl (S)-2-[[(4-methylphenyl)sulfonyl]oxy]propanoate

(+)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>-propionsaeure-ethylester
71283-67-5

(+)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>-propionsaeure-ethylester

Conditions
ConditionsYield
With potassium carbonate In cyclohexane for 17h; Heating / reflux;77%
With potassium carbonate In acetonitrile for 21h; Heating;
ethyl 4-bromo 2-pentenoate
71101-32-1

ethyl 4-bromo 2-pentenoate

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

Ethyl 4-[4(2,4-dichlorophenoxy)phenoxy](2)-pentenoate
72281-60-8

Ethyl 4-[4(2,4-dichlorophenoxy)phenoxy](2)-pentenoate

Conditions
ConditionsYield
With sodium carbonate
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

2-Bromo-propionic acid 2-methoxy-ethyl ester

2-Bromo-propionic acid 2-methoxy-ethyl ester

2-[4-(2,4-Dichloro-phenoxy)-phenoxy]-propionic acid 2-methoxy-ethyl ester
65633-35-4

2-[4-(2,4-Dichloro-phenoxy)-phenoxy]-propionic acid 2-methoxy-ethyl ester

Conditions
ConditionsYield
(i) K2CO3, DMF, (ii) /BRN= 6287738/; Multistep reaction;
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

propionyl chloride
79-03-8

propionyl chloride

Propionic acid 4-(2,4-dichloro-phenoxy)-phenyl ester
62966-67-0

Propionic acid 4-(2,4-dichloro-phenoxy)-phenyl ester

Conditions
ConditionsYield
(i) aq. NaOH, toluene, (ii) /BRN= 385632/; Multistep reaction;
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

ethyl 2-phenyl-2-bromoacetate
2882-19-1

ethyl 2-phenyl-2-bromoacetate

[4-(2,4-Dichloro-phenoxy)-phenoxy]-phenyl-acetic acid
40843-41-2

[4-(2,4-Dichloro-phenoxy)-phenoxy]-phenyl-acetic acid

Conditions
ConditionsYield
(i) K2CO3, MeCOEt, (ii) aq. NaOH, MeOH; Multistep reaction;
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

2-chloro-propanoic acid, ethyl ester
535-13-7

2-chloro-propanoic acid, ethyl ester

D-(+)-2-[4-(2,4-dichlorophenoxy)-phenoxy]-propionic acid ethyl ester
51338-06-8

D-(+)-2-[4-(2,4-dichlorophenoxy)-phenoxy]-propionic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In butanone Heating;
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

ethyl 2-chloro-2-phenylacetate
10606-73-2, 99531-04-1, 116836-53-4, 4773-33-5

ethyl 2-chloro-2-phenylacetate

[4-(2,4-Dichloro-phenoxy)-phenoxy]-phenyl-acetic acid
40843-41-2

[4-(2,4-Dichloro-phenoxy)-phenoxy]-phenyl-acetic acid

Conditions
ConditionsYield
(i) K2CO3, MeCOEt, (ii) aq. NaOH, MeOH; Multistep reaction;
3-(1,3-dioxolan-2-yl)-phenylbromide
17789-14-9

3-(1,3-dioxolan-2-yl)-phenylbromide

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

3-[4-(2,4-Dichloro-phenoxy)-phenoxy]-benzaldehyde

3-[4-(2,4-Dichloro-phenoxy)-phenoxy]-benzaldehyde

Conditions
ConditionsYield
With pyridine; sodium hydride; copper(I) bromide 1.) DMF, 130 deg C, 15 min, 2.) DMF, reflux, 12 h; Multistep reaction;
Methyl 2-bromopropionate
5445-17-0

Methyl 2-bromopropionate

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

A

D-(+)-2-<4-(2,4-Dichlorphenoxy)-phenoxy>propionsaeuremethylester

D-(+)-2-<4-(2,4-Dichlorphenoxy)-phenoxy>propionsaeuremethylester

B

L-(-)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>propionsaeuremethylester

L-(-)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>propionsaeuremethylester

Conditions
ConditionsYield
Yield given. Multistep reaction. Title compound not separated from byproducts;
...Expand
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

1-Azidomethoxy-4-chloro-2-chloromethyl-benzene
96239-02-0

1-Azidomethoxy-4-chloro-2-chloromethyl-benzene

C20H14Cl3N3O3

C20H14Cl3N3O3

Conditions
ConditionsYield
With potassium carbonate In ethanol 25 deg C, 1 h ; 65 deg C, 6 h; Yield given;
6-chloro-2,4-dimethoxypyrimidine
6320-15-6

6-chloro-2,4-dimethoxypyrimidine

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

4-[4-(2,4-dichloro-phenoxy)-phenoxy]-2,6-dimethoxy-pyrimidine

4-[4-(2,4-dichloro-phenoxy)-phenoxy]-2,6-dimethoxy-pyrimidine

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide Substitution;
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

diclofop
40843-25-2

diclofop

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 94 percent / K2CO3 / acetone / 20 h / Heating
2: 89 percent / 33percent NaOH / methanol / 2.5 h / Heating
View Scheme
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

D-(+)-2-<4-(2,4-Dichlorphenoxy)-phenoxy>propionsaeure

D-(+)-2-<4-(2,4-Dichlorphenoxy)-phenoxy>propionsaeure

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / K2CO3 / acetone / 20 h / Heating
2: 89 percent / 33percent NaOH / methanol / 2.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: K2CO3 / acetonitrile / 21 h / Heating
2: 33percent NaOH / 1.) CH3OH, 2.5 h, reflux
View Scheme
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

L-(-)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>propionsaeure
75021-71-5

L-(-)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>propionsaeure

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 94 percent / K2CO3 / acetone / 20 h / Heating
2: 89 percent / 33percent NaOH / methanol / 2.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: 94 percent / K2CO3 / acetone / 20 h / Heating
2: 3.0 g / 33percent NaOH / methanol / 2.5 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: K2CO3 / acetonitrile / 21 h / Heating
2: 33percent NaOH / 1.) CH3OH, 2.5 h, reflux
View Scheme
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

L-(-)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>propionsaeuremethylester

L-(-)-2-<4-(2.4-Dichlorphenoxy)-phenoxy>propionsaeuremethylester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: 94 percent / K2CO3 / acetone / 20 h / Heating
2: 89 percent / 33percent NaOH / methanol / 2.5 h / Heating
4: 89 percent / diethyl ether
View Scheme
Multi-step reaction with 3 steps
1: 94 percent / K2CO3 / acetone / 20 h / Heating
2: 3.0 g / 33percent NaOH / methanol / 2.5 h / Heating
3: 89 percent / diethyl ether
View Scheme
Multi-step reaction with 3 steps
1: K2CO3 / acetonitrile / 21 h / Heating
2: 33percent NaOH / 1.) CH3OH, 2.5 h, reflux
3: 89 percent / diethyl ether
View Scheme
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

3-(2,2-Dichloro-vinyl)-2,2-dimethyl-cyclopropanecarboxylic acid cyano-{3-[4-(2,4-dichloro-phenoxy)-phenoxy]-phenyl}-methyl ester

3-(2,2-Dichloro-vinyl)-2,2-dimethyl-cyclopropanecarboxylic acid cyano-{3-[4-(2,4-dichloro-phenoxy)-phenoxy]-phenyl}-methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 1.) NaH, 2.) CuBr, pyridine / 1.) DMF, 130 deg C, 15 min, 2.) DMF, reflux, 12 h
2: 67 percent / Bu4NBr / H2O; toluene / 6 h / 25 °C
View Scheme
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

4-Chloro-2-[4-(2,4-dichloro-phenoxy)-phenoxymethyl]-phenol
120676-92-8

4-Chloro-2-[4-(2,4-dichloro-phenoxy)-phenoxymethyl]-phenol

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: K2CO3 / ethanol / 25 deg C, 1 h ; 65 deg C, 6 h
2: 88 percent / H2 / Pd/C / ethyl acetate / 25 °C
View Scheme
N-[l-(-)-2-tosyloxypropionyl]isoxazolidine

N-[l-(-)-2-tosyloxypropionyl]isoxazolidine

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

N-[(+/-)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionyl]isoxazolidine

N-[(+/-)-2-[4-(2,4-dichlorophenoxy)phenoxy]propionyl]isoxazolidine

Conditions
ConditionsYield
With potassium carbonate In acetonitrile; benzene
ethyl acetate n-hexane

ethyl acetate n-hexane

t-butyl 2(R)-hydroxypropionate
59854-10-3

t-butyl 2(R)-hydroxypropionate

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

diethylazodicarboxylate
1972-28-7

diethylazodicarboxylate

tert-butyl (2R)-(+)-2-[4'-(2",4"-dichlorophenoxy)phenoxy]propionate

tert-butyl (2R)-(+)-2-[4'-(2",4"-dichlorophenoxy)phenoxy]propionate

Conditions
ConditionsYield
With triphenylphosphine In tetrahydrofuran
...Expand
2-chloro-propionic acid methyl ester
17639-93-9

2-chloro-propionic acid methyl ester

4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

diclofop
40843-25-2

diclofop

Conditions
ConditionsYield
With sodium hydroxide In methanol; 5,5-dimethyl-1,3-cyclohexadiene; water
4-(2',4'-dichlorophenoxy)-phenol
40843-73-0

4-(2',4'-dichlorophenoxy)-phenol

methyl 2-{[(4-methylphenyl)sulfonyl]oxy}propanoate
66648-29-1

methyl 2-{[(4-methylphenyl)sulfonyl]oxy}propanoate

diclofop-methyl
51338-27-3

diclofop-methyl

Conditions
ConditionsYield
With potassium carbonate In acetonitrile

4-(2,4-Dichlorophenoxy)phenol Specification

The cas register number of 4-(2,4-Dichlorophenoxy)phenol is 40843-73-0. It also can be called as 4-(2,4-Dichlorphenoxy)phenol and the Systematic name about this chemical is Phenol, 4-(2,4-dichlorophenoxy)-.

Physical properties about 4-(2,4-Dichlorophenoxy)phenol are: (1)ACD/LogP: 4.35; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 4.34; (4)ACD/LogD (pH 7.4): 4.34; (5)ACD/BCF (pH 5.5): 1180.04; (6)ACD/BCF (pH 7.4): 1174.46; (7)ACD/KOC (pH 5.5): 5501.17; (8)ACD/KOC (pH 7.4): 5475.18; (9)#H bond acceptors: 2; (10)#H bond donors: 1; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 18.46Å2; (13)Index of Refraction: 1.623; (14)Molar Refractivity: 64.36 cm3; (15)Molar Volume: 182.3 cm3; (16)Surface Tension: 50.1 dyne/cm; (17)Density: 1.398 g/cm3; (18)Flash Point: 167.9 °C; (19)Enthalpy of Vaporization: 62.26 kJ/mol; (20)Boiling Point: 354 °C at 760 mmHg; (21)Vapour Pressure: 1.69E-05 mmHg at 25°C.

Uses of 4-(2,4-Dichlorophenoxy)phenol: It reacts with 2-bromo-propionic acid methyl ester to get methyl 2-[4-(2,4-dichlorophenoxy)phenoxy]propionate. This reaction needs solvent solution. The reaction time is 20 hours. The yield is 94 %.

People can use the following data to convert to the molecule structure.
1.SMILES: Clc2cc(Cl)ccc2Oc1ccc(O)cc1
2.InChI: InChI=1/C12H8Cl2O2/c13-8-1-6-12(11(14)7-8)16-10-4-2-9(15)3-5-10/h1-7,15H 
3.InChIKey: DPRSKCAGYLXDCY-UHFFFAOYAH
4.Std. InChI: InChI=1S/C12H8Cl2O2/c13-8-1-6-12(11(14)7-8)16-10-4-2-9(15)3-5-10/h1-7,15H

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