• Name

  4,4'-bis(2,3-epoxypropoxy)biphenyl

• EINECS 219-556-2
• CAS No. 2461-46-3
• Article Data8
• CAS DataBase
• Density 1.226g/cm³
• Solubility
• Melting Point 156 °C
• Formula C18H18 O4
• Boiling Point 473.6°Cat760mmHg
• Molecular Weight 298.339
• Flash Point 171.5°C
• Transport Information
• Appearance
• Safety
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms Biphenyl,4,4'-bis(2,3-epoxypropoxy)- (7CI,8CI); 4,4'-Biphenyldiol diglycidyl ether;4,4'-Bis(2,3-epoxypropoxy)biphenyl; 4,4'-Bisglycidyloxybiphenyl;4,4'-Dihydroxybiphenyl diglycidyl ether; Biphenyl-4,4'-diglycidyl ether;p,p'-Bisphenol diglycidyl ether; p-(2,3-Epoxypropoxy)diphenyl
• PSA 43.52000
• LogP 2.90880

Synthetic route

92-88-6

4,4'-Dihydroxybiphenyl

106-89-8

epichlorohydrin

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

Conditions

Conditions	Yield
Stage #1: 4,4'-Dihydroxybiphenyl With sodium hydride In N,N-dimethyl-formamide for 0.166667h; Inert atmosphere; Stage #2: epichlorohydrin In N,N-dimethyl-formamide at 20℃; for 48h; Inert atmosphere; Stage #3: With water In N,N-dimethyl-formamide at 20℃; Inert atmosphere;	68%
With sodium hydroxide	65%
With tetramethylammonium bromide In dimethyl sulfoxide at 80℃; for 0.666667h;	53%
Heating;
Stage #1: 4,4'-Dihydroxybiphenyl; epichlorohydrin With trimethylbenzylammonium bromide for 0.666667h; Reflux; Stage #2: With sodium hydroxide at 20℃; for 4h; Reflux;

92-88-6

4,4'-Dihydroxybiphenyl

106-89-8

epichlorohydrin

A

1-chloro-3-[4'-(3-chloro-2-hydroxy-propoxy)-biphenyl-4-yloxy]-propan-2-ol

B

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

Conditions

Conditions	Yield
With potassium hydroxide at 20℃; Title compound not separated from byproducts;

...Expand

123-91-1

1,4-dioxane

92-69-3

4-Phenylphenol

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

Conditions

Conditions	Yield
With sodium sulfate; methyloxirane; potassium hydroxide In chloroform

109-89-7

diethylamine

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

106-89-8

epichlorohydrin

4,4'-bis(3-N,N-diethylamino-2-hydroxypropanoxy)biphenyl

Conditions

Conditions	Yield
Stage #1: 4,4'-bis(2,3-epoxypropoxy)biphenyl; epichlorohydrin With potassium hydroxide at 20℃; Stage #2: diethylamine In ethanol	50%

...Expand

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

1-chloro-3-[4'-(3-chloro-2-hydroxy-propoxy)-biphenyl-4-yloxy]-propan-2-ol

Conditions

Conditions	Yield
With cerium(III) chloride heptahydrate In acetonitrile for 16h; Reflux;	28%

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

C30H50N2O4(2+)*2Br(1-)

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1.1: aq. KOH / 20 °C 1.2: 50 percent / ethanol 2.1: 87 percent / acetone / 6 h / Heating View Scheme

79-10-7

acrylic acid

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

166596-79-8

C24H26O8

Conditions

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; hydroquinone Heating;

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

C30H45NO9Si

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydroxide; tetraethylammonium bromide / tetrahydrofuran; acetonitrile / 2.5 h / 26 °C 2: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 h / 65 °C View Scheme

64-17-5

ethanol

2461-46-3

4,4'-bis(2,3-epoxypropoxy)biphenyl

C20H24O5

Conditions

Conditions	Yield
With tetraethylammonium bromide; sodium hydroxide In tetrahydrofuran; acetonitrile at 26℃; for 2.5h;

4,4'-Bis(2,3-epoxypropoxy)biphenyl Chemical Properties

4,4'-Bis(2,3-epoxypropoxy)biphenyl Specification