4',4'''-Sulfonylbis(acetanilide) supplier

Name
acedapsone
EINECS
CAS No. 77-46-3
Article Data36
CAS DataBase
Density 1.362g/cm³
Solubility
Melting Point 289-292°
Formula C₁₆H₁₆N₂O₄S
Boiling Point 661°C at 760 mmHg
Molecular Weight 332.38
Flash Point 353.6°C
Transport Information
Appearance
Safety Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.
Risk Codes
Molecular Structure
Hazard Symbols
Synonyms Camilan;DADDS;Hansolar;Sulfodiamin;4,4'-diacetylaminodiphenylsulphone;4,4'-di-N-acetylaminodiphenyl sulfone;Acetamin;4,4'-diacetamidodiphenyl sulphone;4,4'''-sulfonylbis(acetanilide);Acetamide, N,N‘-(sulfonyldi-4,1-phenylene)bis-;4,4'-bis(acetylamino)diphenyl sulfone;Sulfodiamine;Acedapsone;Rodilone;Sulfadiamine;N,N'-[4,4'-sulfinylbis(4,1-phenylene)]diacetamide;Diacetyldapsone;
PSA 100.72000
LogP 3.66300

4',4'''-Sulfonylbis(acetanilide) Chemical Properties

Molecule structure of 4',4'''-Sulfonylbis(acetanilide) (CAS NO.77-46-3) :

IUPAC Name: N-[4-(4-acetamidophenyl)sulfonylphenyl]acetamide
Molecular Weight: 332.37424 g/mol
Molecular Formula: C₁₆H₁₆N₂O₄S
Density: 1.362 g/cm³
Melting Point: 290 deg C
Boiling Point: 661 °C at 760 mmHg
Flash Point: 353.6 °C
Appreance: white or slightly yellow crystalline
Molar Volume: 243.9 cm³
Polarizability: 34.22*10^-24 cm³
Surface Tension: 60.5 dyne/cm
Enthalpy of Vaporization: 97.26 kJ/mol
Vapour Pressure: 2.41E-17 mmHg at 25 °C
log P (octanol-water): 0.820
Atmospheric OH Rate Constant: 5.51E-12 cm³/molecule-sec
XLogP3-AA: 1.1
H-Bond Donor: 2
H-Bond Acceptor: 4
Rotatable Bond Count: 4
Tautomer Count: 3
Exact Mass: 332.083078
MonoIsotopic Mass: 332.083078
Topological Polar Surface Area: 92.3
Heavy Atom Count: 23
Complexity: 483
Canonical SMILES: CC(=O)NC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C
InChI: InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)
InChIKey: AMTPYFGPPVFBBI-UHFFFAOYSA-N
EINECS: 201-028-8

4',4'''-Sulfonylbis(acetanilide) Uses

4',4'''-Sulfonylbis(acetanilide) (CAS NO.77-46-3) is used as anti-leprosy drugs.

4',4'''-Sulfonylbis(acetanilide) Production

By dapsone, acetic acid and acetic anhydride heated reflux, acetylation obtained. The crude will be added in ethanol refining decolorizing activated carbon, available benzene sulfone acetamide boutique. Pairs of dapsone, total yield was about 76%.

4',4'''-Sulfonylbis(acetanilide) Toxicity Data With Reference

orl-rat TDLo:4200 mg/kg/43W-C:CAR

JNCIAM Journal of the National Cancer Institute. 24 (1960),149.

4',4'''-Sulfonylbis(acetanilide) Safety Profile

Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits very toxic fumes of NO_x and SO_x.

4',4'''-Sulfonylbis(acetanilide) Specification

4',4'''-Sulfonylbis(acetanilide) (CAS NO.77-46-3) is also called 4',4'''-Sulfonylbis(acetanilidec) ; 4,4'-Bis(acetylamino)diphenyl sulfone ; 4,4'-Diacetamidodiphenyl sulfone ; 4,4'-Diacetylaminodiphenyl sulfone ; 4,4'-Diacetyldiaminodiphenyl sulfone ; Acedafsonum [Latin] ; Acedapsona [INN-Spanish] ; Acedapsona [Spanish] ; Acedapsone ; Acedapsonum [INN-Latin] ; Acetamide. N,N'-(sulfonyldi-4,1-phenylene)bis- ; Acetamin ; Acetanilide, 4',4'''-sulfonyldi- ; N,N'-(Sulfonyldi-4,1-phenylene)bisacetamide ; N,N'-Diacetyl-4,4'-diaminodiphenyl sulfone ; N,N'-Diacetyl-4,4'-diaminophenyl sulfone ; N,N'-Diacetyldapsone . 4',4'''-Sulfonylbis(acetanilide) (CAS NO.77-46-3) is odorless and almost insoluble in water.

Product Name

acedapsone