4-CHLORO-2,8-DIMETHYLQUINOLINE

The CAS register number of Quinoline,4-chloro-2,8-dimethyl- is 32314-39-9. It also can be called as 4-Chloro-2-methyl-8-methylquinoline and the systematic name about this chemical is 4-chloro-2,8-dimethylquinoline. The molecular formula about this chemical is C₁₁H₁₀ClN and the molecular weight is 191.66.

Physical properties about Quinoline,4-chloro-2,8-dimethyl- are: (1)ACD/LogP: 3.70; (2)#H bond acceptors: 1; (3)Polar Surface Area: 12.89 Å²; (4)Index of Refraction: 1.621; (5)Molar Refractivity: 56.73 cm³; (6)Molar Volume: 161.2 cm³; (7)Polarizability: 22.49x10^-24cm³; (8)Surface Tension: 44.4 dyne/cm; (9)Density: 1.188 g/cm³; (10)Flash Point: 152.4 °C; (11)Enthalpy of Vaporization: 50.15 kJ/mol; (12)Boiling Point: 283.5 °C at 760 mmHg; (13)Vapour Pressure: 0.00538 mmHg at 25 °C.

Preparation: this chemical can be prepared by 2,8-dimethyl-quinolin-4-ol and N,N-dimethyl-formamide. This reaction will need reagent of POCl₃ and it is a kind of Vilsmeier-Haack reaction. The reaction needs heating and the reaction time is 12.5 hours. The yield is about 73.5%.

Uses of Quinoline,4-chloro-2,8-dimethyl-: it can be used to produce 2,8-dimethyl-4-(2-methyl-piperidin-1-yl)-quinoline with 2-methyl-piperidine. This reaction will need reagent of pyridine and solvent of ethanol. This reaction needs heating and the reaction time is 8 hours. The yield is about 85%.

When you are using this chemical, please be cautious about it as the following:
This chemical is harmful by inhalation, in contact with skin and if swallowed and it may cause damage to health. It is irritating to eyes, respiratory system and skin. If you want to use this chemical, wear suitable protective clothing. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If no official permission, do not put materials into the permission surroundings. If you want to store it, you should keep the container tightly sealed in dry, cool places. Please ensure that the workshop is well ventilated or equipped with exhaust device and if you store and use this chemical according the rule, it will not be decomposed.

You can still convert the following datas into molecular structure:
(1)SMILES: Clc1c2cccc(c2nc(c1)C)C
(2)InChI: InChI=1/C11H10ClN/c1-7-4-3-5-9-10(12)6-8(2)13-11(7)9/h3-6H,1-2H3
(3)InChIKey: ILOAZUIOTZZIBK-UHFFFAOYAV
(4)Std. InChI: InChI=1S/C11H10ClN/c1-7-4-3-5-9-10(12)6-8(2)13-11(7)9/h3-6H,1-2H3
(5)Std. InChIKey: ILOAZUIOTZZIBK-UHFFFAOYSA-N