• Name

  (2R)-2-[(5alpha,18R)-3,6-dimethoxy-17-methyl-7,8-didehydro-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-18-yl]-4-phenylbutan-2-ol

• EINECS
• CAS No. 13965-63-4
• Article Data3
• CAS DataBase
• Density 1.27g/cm³
• Solubility
• Melting Point
• Formula C31H37 N O4
• Boiling Point °Cat760mmHg
• Molecular Weight 487.639
• Flash Point °C
• Transport Information
• Appearance
• Safety A poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NO_x.
• Risk Codes
• Molecular Structure
• Hazard Symbols
• Synonyms 6,14-Ethenomorphinan-7-methanol,4,5-epoxy-3,6-dimethoxy-a,17-dimethyl-a-(2-phenylethyl)-, [5a,7a(R)]-;6,14-endo-Ethenotetrahydrothebaine, 7a-(1-hydroxy-1-methyl-3-phenylpropyl)-(8CI)
• PSA 51.16000
• LogP 4.23720

Synthetic route

15358-22-2

thevinone

2-phenyl-ethylmagnesium halide

2-phenyl-ethylmagnesium halide

13965-63-4

(R)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinan-7α-yl)-4-phenyl-butan-2-ol

13965-63-4

(R)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinan-7α-yl)-4-phenyl-butan-2-ol

14521-98-3

(20R)-phenethyl-orvinol

Conditions

Conditions	Yield
With potassium hydroxide In diethylene glycol Heating;

13965-63-4

(R)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinan-7α-yl)-4-phenyl-butan-2-ol

36418-76-5

(R)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphin-15-en-7α-yl)-4-phenyl-butan-2-ol

Conditions

Conditions	Yield
With hydrogen sulfide; mercury(II) oxide In acetic acid

13965-63-4

(R)-2-(4,5α-epoxy-3,6-dimethoxy-17-methyl-6α,14α-etheno-morphinan-7α-yl)-4-phenyl-butan-2-ol

16620-48-7, 16659-03-3

(2R,2'R)-4,4'-diphenyl-2,2'-[4,5α;4',5'α-diepoxy-3,6,3',6'-tetramethoxy-17,17'-methanediyl-bis-(6α,14α-etheno-morphinan-7α-yl)]-bis-butan-2-ol

Conditions

Conditions	Yield
(i) diazenedicarbocylic acid diethyl ester, acetone, (ii) aq. H2O; Multistep reaction;

6,14-Ethenomorphinan-7-methanol, 3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-(2-phenylethyl)-, (5-alpha,7-alpha(R))- Chemical Properties

6,14-Ethenomorphinan-7-methanol, 3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-(2-phenylethyl)-, (5-alpha,7-alpha(R))- Toxicity Data With Reference

6,14-Ethenomorphinan-7-methanol, 3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-(2-phenylethyl)-, (5-alpha,7-alpha(R))- Safety Profile

6,14-Ethenomorphinan-7-methanol, 3,6-dimethoxy-alpha,17-dimethyl-4,5-epoxy-alpha-(2-phenylethyl)-, (5-alpha,7-alpha(R))- Specification