neutral red
Conditions | Yield |
---|---|
With sodium nitrite In water for 2h; | 68% |
neutral red
3,N8,N8-trimethyl-5,10-dihydro-phenazine-2,8-diamine
Conditions | Yield |
---|---|
With sodium dithionite bei pH 8.2; |
neutral red
Conditions | Yield |
---|---|
With sodium nitrite In water for 2h; | 68% |
neutral red
3,N8,N8-trimethyl-5,10-dihydro-phenazine-2,8-diamine
Conditions | Yield |
---|---|
With sodium dithionite bei pH 8.2; |
neutral red
Conditions | Yield |
---|---|
beim Acetylieren; |
neutral red
Conditions | Yield |
---|---|
beim Acetylieren; |
Conditions | Yield |
---|---|
at 160 - 170℃; folgendes Kochen mit Salzsaeure; |
Conditions | Yield |
---|---|
at 100℃; folgendes Kochen mit Salzsaeure; |
neutral red
Conditions | Yield |
---|---|
In water at 40℃; Thermodynamic data; Equilibrium constant; further temperatures, solvents, salts, ΔG(activ.), ΔH(activ.), ΔS(activ.); |
Conditions | Yield |
---|---|
at 25℃; pH=7.2; aq. phosphate buffer; |
Conditions | Yield |
---|---|
at 25℃; pH=7.2; aq. phosphate buffer; |
Conditions | Yield |
---|---|
at 25℃; pH=7.2; aq. phosphate buffer; |
neutral red
tetrasodium 25,26,27,28-tetrahydroxycalix[4]arene-5,11,17,23-tetrasulfonate
Conditions | Yield |
---|---|
at 25℃; pH=4.5; aq. acetate buffer; |
neutral red
sodium p-sulfonatocalix[6]arene
Conditions | Yield |
---|---|
at 25℃; pH=4.5; aq. acetate buffer; |
neutral red
octasodium salt of 5,11,17,23,29,35,41,47-octasulfonatocalix<8>arene
Conditions | Yield |
---|---|
at 25℃; pH=4.5; aq. acetate buffer; |
Conditions | Yield |
---|---|
In aq. phosphate buffer; water-d2 pH=7.4; |
Conditions | Yield |
---|---|
In water |
Conditions | Yield |
---|---|
In water pH=Ca. 5; |
Conditions | Yield |
---|---|
In aq. phosphate buffer pH=7.5; |
Conditions | Yield |
---|---|
In aq. phosphate buffer pH=7.5; |
Conditions | Yield |
---|---|
In aq. phosphate buffer pH=7.4; Kinetics; |
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
The IUPAC name of Nuclear Red is 8-N,8-N,3-trimethylphenazine-2,8-diamine hydrochloride. With the CAS registry number 553-24-2, it is also named as 3-Amino-7-dimethylamino-2-methylphenazine hydrochloride. The product's categories are organics; analytical chemistry; indicator (pH); pH indicators; stains and dyes. It is dark green powder which is stable and incompatible with strong oxidizing agents. Nuclear Red is highly toxic and flammable. When buring it will produce toxic nitrogen oxide and hydrogen chloride fumes. In addition, the storage environment should be ventilate, low-temperature and dry.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 2.70; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 2.41; (4)ACD/LogD (pH 7.4): 2.7; (5)ACD/BCF (pH 5.5): 33.69; (6)ACD/BCF (pH 7.4): 65.71; (7)ACD/KOC (pH 5.5): 355.67; (8)ACD/KOC (pH 7.4): 693.68; (9)#H bond acceptors: 4; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 2; (12)Enthalpy of Vaporization: 76.53 kJ/mol; (13)Vapour Pressure: 4.99E-10 mmHg at 25°C; (14)Rotatable Bond Count: 1; (15)Tautomer Count: 4; (16)Exact Mass: 288.114174; (17)MonoIsotopic Mass: 288.114174; (18)Topological Polar Surface Area: 55; (19)Heavy Atom Count: 20.
Uses of Nuclear Red: It is not only used as a vital stain, to stain living cells, but also used to stain cell cultures for plate titration of viruses. And it is also added to some growth media for bacteria and cell cultures. Furthermore, it acts as a pH indicator, changing from red to yellow between the pH 6.8-8.0.
When you are using this chemical, please be cautious about it as the following:
It is irritating to eyes, respiratory system and skin. And it has possible risk of irreversible effects. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection.
People can use the following data to convert to the molecule structure.
1. SMILES: Cl.n1c3c(nc2c1cc(c(c2)N)C)cc(N(C)C)cc3;
2. InChI: InChI=1/C15H16N4.ClH/c1-9-6-13-15(8-11(9)16)18-14-7-10(19(2)3)4-5-12(14)17-13;/h4-8H,16H2,1-3H3;1H.
The following are the toxicity data which has been tested.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 432mg/kg (432mg/kg) | Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. Vol. 25, Pg. 356, 1990. | |
mouse | LD50 | intravenous | 142mg/kg (142mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES CARDIAC: OTHER CHANGES | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 10, Pg. 337, 1951. |
rabbit | LD50 | intravenous | 96600ug/kg (96.6mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION | Stanford Medical Bulletin. Vol. 9, Pg. 96, 1951. |
rat | LD50 | intravenous | 112mg/kg (112mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD CARDIAC: OTHER CHANGES LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES | Federation Proceedings, Federation of American Societies for Experimental Biology. Vol. 10, Pg. 337, 1951. |
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