(1,1,2,2-TETRAFLUOROETHOXY)BENZENE

The Benzene,(1,1,2,2-tetrafluoroethoxy)-, with the CAS registry number 350-57-2, is also known as Phenyl 1,1,2,2-tetrafluoroethyl ether. It belongs to the product categories of Ethers; Organic Building Blocks; Oxygen Compounds. Its EINECS number is 206-505-4. This chemical's molecular formula is C₈H₆F₄O and molecular weight is 194.13. What's more, its systematic name is 1,1,2,2-tetrafluoroethoxybenzene.

Physical properties of Benzene,(1,1,2,2-tetrafluoroethoxy)- are: (1)ACD/LogP: 3.40; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.4; (4)ACD/LogD (pH 7.4): 3.4; (5)ACD/BCF (pH 5.5): 224.46; (6)ACD/BCF (pH 7.4): 224.46; (7)ACD/KOC (pH 5.5): 1677.07; (8)ACD/KOC (pH 7.4): 1677.07; (9)#H bond acceptors: 1; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 3; (12)Polar Surface Area: 9.23 Å²; (13)Index of Refraction: 1.415; (14)Molar Refractivity: 38.14 cm³; (15)Molar Volume: 152.1 cm³; (16)Polarizability: 15.12×10^-24cm³; (17)Surface Tension: 23.2 dyne/cm; (18)Density: 1.275 g/cm³; (19)Flash Point: 45.8 °C; (20)Enthalpy of Vaporization: 37.51 kJ/mol; (21)Boiling Point: 154.5 °C at 760 mmHg; (22)Vapour Pressure: 4.07 mmHg at 25°C.

Preparation of Benzene,(1,1,2,2-tetrafluoroethoxy)-: this chemical can be prepared by 1,2-dibromo-1,1,2,2-tetrafluoro-ethane and phenol; potassium salt at the ambient temperature. This reaction will need solvent hexamethylphosphoric acid triamide with the reaction time of 6 hours. The yield is about 83%.

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable. It is irritating to eyes, respiratory system and skin. In case of contact with eyes, you should rinse immediately with plenty of water and seek medical advice. When using it, you need wear suitable protective clothing.

You can still convert the following datas into molecular structure:
(1)Canonical SMILES: C1=CC=C(C=C1)OC(C(F)F)(F)F
(2)InChI: InChI=1S/C8H6F4O/c9-7(10)8(11,12)13-6-4-2-1-3-5-6/h1-5,7H
(3)InChIKey: GRDIVJPQARIBNZ-UHFFFAOYSA-N

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
mouse	LD50	oral	3600mg/kg (3600mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 29(11), Pg. 51, 1985.
rat	LD50	oral	5gm/kg (5000mg/kg)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 29(11), Pg. 51, 1985.