Product Name

  • Name

    Ethyl 2-aminothiazole-5-carboxylate

  • EINECS 676-105-6
  • CAS No. 32955-21-8
  • Article Data19
  • CAS DataBase
  • Density 1.336 g/cm3
  • Solubility Insoluble in water
  • Melting Point 144-148 °C
  • Formula C6H8N2O2S
  • Boiling Point 308 °C at 760 mmHg
  • Molecular Weight 172.208
  • Flash Point 140.1 °C
  • Transport Information
  • Appearance
  • Safety 26-36/37/39
  • Risk Codes 36/37/38
  • Molecular Structure Molecular Structure of 32955-21-8 (Ethyl 2-aminothiazole-5-carboxylate)
  • Hazard Symbols IrritantXi
  • Synonyms 2-Amino-5-(ethoxycarbonyl)thiazole;2-Aminothiazole-5-carboxylic acid ethyl ester;Ethyl 2-amino-1,3-thiazole-5-carboxylate;Ethyl 2-amino-5-thiazolecarboxylate;NSC 233051;Ethyl-2-aminothiazole-5-carboxylate;
  • PSA 93.45000
  • LogP 1.48320

Synthetic route

ethyl 3-ethoxyacrylate
1001-26-9

ethyl 3-ethoxyacrylate

urea
57-13-6

urea

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium sulfide; copper In tetrahydrofuran; water at 55℃; for 1.5h; Temperature; Inert atmosphere;95.7%
ethyl 3-ethoxyacrylate
1001-26-9

ethyl 3-ethoxyacrylate

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl 3-ethoxyacrylate With N-Bromosuccinimide In 1,4-dioxane; water
Stage #2: With thiourea		91%
With ammonium hydroxide; N-Bromosuccinimide; thiourea In 1,4-dioxane; water
thiourea
17356-08-0

thiourea

2-bromo-3-ethoxy-3-hydroxy-propionic acid ethyl ester

2-bromo-3-ethoxy-3-hydroxy-propionic acid ethyl ester

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
In 1,4-dioxane; water at 80℃; for 1h;90%
In 1,4-dioxane; water at 80℃; for 1h;
In 1,4-dioxane at 80℃; for 1h;1.4 g
ethyl 3-ethoxyacrylate
1001-26-9

ethyl 3-ethoxyacrylate

thiourea
17356-08-0

thiourea

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: ethyl 3-ethoxyacrylate With N-Bromosuccinimide In 1,4-dioxane; water at -10 - 20℃; for 1h;
Stage #2: thiourea In 1,4-dioxane; water at 80℃; for 1h;		70%
Stage #1: ethyl 3-ethoxyacrylate With N-Bromosuccinimide In 1,4-dioxane; water at -10 - 20℃; for 1h;
Stage #2: thiourea In 1,4-dioxane; water at 80℃; for 1h;
Stage #3: With ammonium chloride In 1,4-dioxane; water at 20℃; for 0.166667h;		66%
ethyl 2-chloro-3-oxopropanoate
33142-21-1

ethyl 2-chloro-3-oxopropanoate

thiourea
17356-08-0

thiourea

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
In water 1.) reflux, 15 min, 2.) RT, 12 h;67%
ethyl 2-<2-amino-5-(ethoxycarbonyl)-4-thiazolylthio>acetoacetate
111603-56-6

ethyl 2-<2-amino-5-(ethoxycarbonyl)-4-thiazolylthio>acetoacetate

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With nickel In ethanol for 16h; Heating;39%
2-acetylamino-thiazole-5-carbonitrile
99903-61-4

2-acetylamino-thiazole-5-carbonitrile

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With hydrogenchloride at 135℃;
ethyl 3-ethoxyacrylate
5941-55-9

ethyl 3-ethoxyacrylate

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: N-bromosuccinimide / H2O; dioxane / 0.5 h / -10 - 20 °C
2: 90 percent / H2O; dioxane / 1 h / 80 °C
View Scheme
chloroacetic acid ethyl ester
105-39-5

chloroacetic acid ethyl ester

thiourea
17356-08-0

thiourea

formic acid ethyl ester
109-94-4

formic acid ethyl ester

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: chloroacetic acid ethyl ester; formic acid ethyl ester With sodium In ethanol at -10 - -5℃;
Stage #2: thiourea In ethanol at 80℃; for 1.25h;
...Expand
ethyl 3,3-diethoxypropanoate
10601-80-6

ethyl 3,3-diethoxypropanoate

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 2 h / 190 - 200 °C
2: water; N-Bromosuccinimide / 1,4-dioxane / 1 h / -10 - 20 °C
3: 1,4-dioxane / 1 h / 80 °C
View Scheme
ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate
302964-01-8

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
at 225℃; under 38787.1 Torr; for 0.166667h; Flow reactor;
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate
302964-01-8

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
dmap In tetrahydrofuran at 30℃; for 5.5h;99.23%
With dmap In tetrahydrofuran at 30℃; for 5.5h;99.23%
In isopropyl alcohol at 50℃; for 24h;93%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

acetic anhydride
108-24-7

acetic anhydride

ethyl 2-acetamidothiazole-5-carboxylate
106840-37-3

ethyl 2-acetamidothiazole-5-carboxylate

Conditions
ConditionsYield
With pyridine; dmap In dichloromethane at 0℃; for 2h; Reflux;98%
With pyridine; dmap In dichloromethane for 2h; Reflux;98%
With pyridine; dmap In dichloromethane at 0℃; for 2h; Reflux;98%
3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid
300354-95-4

3-cyclopentyl-2-(4-methanesulfonyl-phenyl)propionic acid

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate
56602-33-6

(benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate

2-[3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-propionylamino]-thiazole-5-carboxylic acid ethyl ester
588940-26-5

2-[3-cyclopentyl-2-(4-methanesulfonyl-phenyl)-propionylamino]-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine In dichloromethane98%
...Expand
2,4-dichloro-2-methylpyrimidine
1780-26-3

2,4-dichloro-2-methylpyrimidine

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate
1202357-66-1

ethyl 2-[(6-chloro-2-methylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 72h; Inert atmosphere;98%
With sodium hydride In N,N-dimethyl-formamide at 0℃; for 3h; Inert atmosphere;87%
With caesium carbonate In N,N-dimethyl-formamide at 25℃; for 24h; Cooling with ice;83.5%
With caesium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 8.08333h;82%
With sodium hydride In N,N-dimethyl-formamide at 0 - 20℃; for 3h;81%
cupric chloride

cupric chloride

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-chloro-thiazole-5-carboxylate
81449-93-6

ethyl 2-chloro-thiazole-5-carboxylate

Conditions
ConditionsYield
With hydrogenchloride; tert.-butylnitrite In acetonitrile97%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

benzoyl chloride
98-88-4

benzoyl chloride

2-Benzoylamino-thiazole-5-carboxylic acid ethyl ester
196937-70-9

2-Benzoylamino-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With pyridine for 48h; Ambient temperature;95%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

p-tert-butyl benzoyl chloride
1710-98-1

p-tert-butyl benzoyl chloride

2-[N-[4-(1,1-Dimethylethyl)benzoyl]amino]thiazole-5-carboxylic Acid Ethyl Ester
439578-91-3

2-[N-[4-(1,1-Dimethylethyl)benzoyl]amino]thiazole-5-carboxylic Acid Ethyl Ester

Conditions
ConditionsYield
With pyridine In dichloromethane88%
2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine
761440-16-8

2,5-dichloro-N-[2-[(1-methylethyl)sulfonyl]phenyl]-4-pyrimidinamine

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

C19H20ClN5O4S2

C19H20ClN5O4S2

Conditions
ConditionsYield
With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene In 1,4-dioxane at 110℃; Microwave irradiation;87%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-aminothiazole-5-carboxylic acid
40283-46-3

2-aminothiazole-5-carboxylic acid

Conditions
ConditionsYield
With sodium hydroxide In tetrahydrofuran; water Reflux;86%
With sodium hydroxide
With barium dihydroxide
With potassium hydroxide In methanol
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-iodothiazole-5-carboxylate
83553-48-4

ethyl 2-iodothiazole-5-carboxylate

Conditions
ConditionsYield
With toluene-4-sulfonic acid; potassium iodide; sodium nitrite In water; acetonitrile at 0 - 20℃;85%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

o-carboxybenzaldehyde
119-67-5

o-carboxybenzaldehyde

3-[(5-thiazolylcarboxyl-2-yl)amino]-2-benzofuran-1(3H)-one

3-[(5-thiazolylcarboxyl-2-yl)amino]-2-benzofuran-1(3H)-one

Conditions
ConditionsYield
In methanol at 20℃; for 1h; Green chemistry;82%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate
302964-01-8

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
79.5%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

Ethyl-2-tert-butoxycarbonyloxyamino-thiazole-5-carboxylate

Ethyl-2-tert-butoxycarbonyloxyamino-thiazole-5-carboxylate

Conditions
ConditionsYield
79.5%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

(3-bromo-2-oxopropyl)((tert-butyldiphenylsilyl)imino)(phenyl)-λ6-sulfanone

(3-bromo-2-oxopropyl)((tert-butyldiphenylsilyl)imino)(phenyl)-λ6-sulfanone

ethyl 6-((N-(tert-butyldiphenylsilyl)phenylsulfonimidoyl)methyl)imidazo[2,1-b]thiazole-2-carboxylate

ethyl 6-((N-(tert-butyldiphenylsilyl)phenylsulfonimidoyl)methyl)imidazo[2,1-b]thiazole-2-carboxylate

Conditions
ConditionsYield
With sodium hydrogencarbonate In 1,4-dioxane at 90℃; for 15h; Sealed tube; Inert atmosphere;79%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol
127116-19-2

2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol

ethyl (6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate
1245157-39-4

ethyl (6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-formate

Conditions
ConditionsYield
Stage #1: 2-amino-thiazole-5-carboxylic acid ethyl ester; 2-(4-(6-chloro-2-methylpyrimidin-4-yl)piperazin-1-yl)ethanol With caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl In toluene for 16h; Reflux;
Stage #2: With hydrogenchloride In water; toluene for 0.166667h;
Stage #3: With sodium hydroxide In water at 10 - 15℃; for 1h;		70.5%
N'-[2-cyano-4-methoxy-5-(3-morpholin-4-ylpropoxy)phenyl]-N,N-dimethylimidoformamido

N'-[2-cyano-4-methoxy-5-(3-morpholin-4-ylpropoxy)phenyl]-N,N-dimethylimidoformamido

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazole-5-carboxylate
385780-23-4

ethyl 2-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-yl]amino}-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With acetic acid Heating;70%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

di-(tert-butyl) dicarbonate

di-(tert-butyl) dicarbonate

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate
302964-01-8

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With dmap; triethanolamine In tetrahydrofuran68%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

di-tert-butyl dicarbonate
24424-99-5

di-tert-butyl dicarbonate

A

C16H24N2O6S
1215121-72-4

C16H24N2O6S

B

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate
302964-01-8

ethyl 2-[(tert-butoxycarbonyl)amino]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With dmap In dichloromethane for 15h;A 17%
B 65%
...Expand
3,4-dihydro-2H-pyran
110-87-2

3,4-dihydro-2H-pyran

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-(tetrahydro-2H-pyran-2-ylamino)thiazole-5-carboxylate
1029088-17-2

ethyl 2-(tetrahydro-2H-pyran-2-ylamino)thiazole-5-carboxylate

Conditions
ConditionsYield
trifluoroacetic acid In acetonitrile Heating / reflux;64%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

6-(3-ethylureido)nicotinic acid
1251126-74-5

6-(3-ethylureido)nicotinic acid

C15H17N5O4S
1644457-07-7

C15H17N5O4S

Conditions
ConditionsYield
Stage #1: 6-(3-ethylureido)nicotinic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 0.25h;
Stage #2: 2-amino-thiazole-5-carboxylic acid ethyl ester In N,N-dimethyl-formamide at 45℃; for 18h;		63%
2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid
383661-55-0

2-[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetic acid

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

(3R,5S)-N-propanesulfonyl-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide
383653-04-1

(3R,5S)-N-propanesulfonyl-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepine-3-acetamide

isobutyl chloroformate
543-27-1

isobutyl chloroformate

ethyl 5-[[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]amino]-1,3-thiazole-5-carboxylate

ethyl 5-[[[(3R,5S)-1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl]amino]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With pyridine; triethylamine In water; N,N-dimethyl-formamide62.1%
...Expand
3-cyclopentyl-2-(3,4-dichlorophenyl)propionic acid
300355-34-4

3-cyclopentyl-2-(3,4-dichlorophenyl)propionic acid

2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-[3-cyclopentyl-2-(3,4-dichlorophenyl)-propionylamino]-thiazole-5-carboxylic acid ethyl ester

2-[3-cyclopentyl-2-(3,4-dichlorophenyl)-propionylamino]-thiazole-5-carboxylic acid ethyl ester

Conditions
ConditionsYield
With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine In dichloromethane at 25℃; for 14h; Inert atmosphere;61%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-carboxylic acid
368869-97-0

2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-carboxylic acid

ethyl 2-[2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-amido]-1,3-thiazole-5-carboxylate

ethyl 2-[2-(2,3-dihydro-1-benzofuran-5-yl)-1,3-thiazole-4-amido]-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
With pyridine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate at 90℃; for 3h;53%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

ethyl 2-bromo-1,3-thiazole-5-carboxylate
41731-83-3

ethyl 2-bromo-1,3-thiazole-5-carboxylate

Conditions
ConditionsYield
Stage #1: 2-amino-thiazole-5-carboxylic acid ethyl ester With hydrogen bromide; sodium nitrite In water at 0℃;
Stage #2: With hydrogen bromide; copper(I) bromide In water at 0 - 20℃;		50%
Stage #1: 2-amino-thiazole-5-carboxylic acid ethyl ester With hydrogen bromide; sodium nitrite In water at 0℃; for 0.25h;
Stage #2: With hydrogen bromide; copper(I) bromide In water at 0 - 20℃; for 4h;		50.18%
Stage #1: 2-amino-thiazole-5-carboxylic acid ethyl ester With hydrogen bromide; sodium nitrite In water at 0℃; for 0.25h;
Stage #2: With copper(I) bromide In water at 0 - 20℃; for 4h;		50.18%
2-amino-thiazole-5-carboxylic acid ethyl ester
32955-21-8

2-amino-thiazole-5-carboxylic acid ethyl ester

2-nitrochalcone
53744-31-3, 7473-93-0

2-nitrochalcone

C21H17N3O3S

C21H17N3O3S

Conditions
ConditionsYield
With diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; potassium carbonate In ethanol at 90℃; for 1h; Schlenk technique; Inert atmosphere;45%

Ethyl 2-aminothiazole-5-carboxylate Chemical Properties

Empirical Formula: C6H8N2O2S
Molecular Weight: 172.2049
Nominal Mass: 172 Da
Average Mass: 172.2049 Da
Monoisotopic Mass: 172.030648 Da 
Index of Refraction: 1.588 Molar
Refractivity: 43.37 cm3
Molar Volume: 128.8 cm3
Surface Tension: 57.7 dyne/cm
Density: 1.336 g/cm3
Flash Point: 140.1 °C
Enthalpy of Vaporization: 54.86 kJ/mol
Boiling Point: 308 °C at 760 mmHg
Vapour Pressure: 0.000701 mmHg at 25 °C
Structure of Ethyl 2-aminothiazole-5-carboxylate (CAS NO.32955-21-8):
                         
IUPAC Name: Ethyl 2-amino-1,3-thiazole-5-carboxylate
Canonical SMILES: CCOC(=O)C1=CN=C(S1)N
InChI: InChI=1S/C6H8N2O2S/c1-2-10-5(9)4-3-8-6(7)11-4/h3H,2H2,1H3,(H2,7,8)
InChIKey: VNZXERIGKZNEKB-UHFFFAOYSA-N
Product Category of Ethyl 2-aminothiazole-5-carboxylate (CAS NO.32955-21-8): Amines;Carboxes;Thiazole series;Amines and Anilines;Heterocycles;Heterocycle intermediates

Ethyl 2-aminothiazole-5-carboxylate Safety Profile

Hazard Codes of Ethyl 2-aminothiazole-5-carboxylate (CAS NO.32955-21-8): IrritantXi
Risk Statements: 36/37/38 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.

Ethyl 2-aminothiazole-5-carboxylate Specification

 Ethyl 2-aminothiazole-5-carboxylate , its cas register number is 32955-21-8. It also can be called Ethyl 2-amino-1,3-thiazole-5-carboxylate ; and 2-Amino-5-(ethoxycarbonyl)thiazole .

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