Product Name

  • Name

    Ethyl N-piperazinecarboxylate

  • EINECS 204-395-2
  • CAS No. 120-43-4
  • Article Data28
  • CAS DataBase
  • Density 1.071 g/cm3
  • Solubility soluble in water
  • Melting Point 120 °C
  • Formula C7H14N2O2
  • Boiling Point 237 °C at 760 mmHg
  • Molecular Weight 158.2
  • Flash Point 97.1 °C
  • Transport Information UN 2810 6.1/PG 3
  • Appearance clear light yellow oily liquid
  • Safety 23-24/25-37/39-26-36
  • Risk Codes 22-36/37/38-20/21/22
  • Molecular Structure Molecular Structure of 120-43-4 (Ethyl N-piperazinecarboxylate)
  • Hazard Symbols HarmfulXn,ToxicT
  • Synonyms 1-(Ethoxycarbonyl)piperazine;1-Carbethoxypiperazine;1-Carboethoxypiperazine;4-Carbethoxypiperazine;Ethyl1-piperazinecarboxylate;N-(Ethoxycarbonyl)piperazine;N-Carbethoxypiperazine;N-Carboethoxypiperazine;NSC 21060;NSC 22134;NSC 280827;
  • PSA 41.57000
  • LogP 0.31480

Synthetic route

piperazine
110-85-0

piperazine

Diethyl carbonate
105-58-8

Diethyl carbonate

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
at 80℃; for 3h;98.5%
1-(ethylcarboxy)-4-benzylpiperazine
59325-12-1

1-(ethylcarboxy)-4-benzylpiperazine

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
With hydrogen; palladium on activated charcoal In ethanol under 2206.5 Torr; for 4h;78%
piperazine-1,4-dicarboxylic acid ethyl ester methyl ester

piperazine-1,4-dicarboxylic acid ethyl ester methyl ester

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
With L-Selectride In tetrahydrofuran at 20℃; for 48h;69%
piperazine
110-85-0

piperazine

chloroformic acid ethyl ester
541-41-3

chloroformic acid ethyl ester

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
In methanol; water at 0 - 25℃; for 4h;33.7%
In methanol; water at 0 - 25℃; for 4h;33.7%
bei pH 2.8-4.6;
bis-cyanomethyl-carbamic acid ethyl ester
86366-60-1

bis-cyanomethyl-carbamic acid ethyl ester

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
With ethanol; nickel Hydrogenation;
O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate
205432-12-8

O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
With GLUTATHIONE; glutathione S-transferase P1-1 at 37℃; pH=7.4; Kinetics; Reagent/catalyst; Enzymatic reaction;
pentaerythritol tetraglycidylether (PETGE)

pentaerythritol tetraglycidylether (PETGE)

pentaerythritol tetraglycidyl ether
3126-63-4

pentaerythritol tetraglycidyl ether

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
In methanol
piperazine
110-85-0

piperazine

ethyl 1-imidazolecarboxylate
19213-72-0

ethyl 1-imidazolecarboxylate

piperazine dihydrochloride
142-64-3

piperazine dihydrochloride

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
Stage #1: piperazine; piperazine dihydrochloride In water for 0.0833333h;
Stage #2: ethyl 1-imidazolecarboxylate With sodium chloride In water for 0.5h;
Stage #3: With sodium hydroxide In water chemoselective reaction;
...Expand
tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate

tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
With hydrogenchloride; water In dichloromethane at 20℃;
Stage #1: tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate With trifluoroacetic acid In dichloromethane at 0 - 20℃; Inert atmosphere;
Stage #2: With ammonia In dichloromethane; water Inert atmosphere; Cooling;
O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate
205432-12-8

O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate

A

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

B

S-(2,4-dinitrophenyl)glutathione
26289-39-4

S-(2,4-dinitrophenyl)glutathione

Conditions
ConditionsYield
With glutathione-S-transferase; glutathion; d(TTTTTTTTAGGATCATGGTGATGCTCTACGTGCCGTAGCCTTTTTTTTT); calcium chloride; magnesium chloride for 0.166667h; pH=7.4; Enzymatic reaction;
methyl 4-benzylpiperazine-1-carboxylate

methyl 4-benzylpiperazine-1-carboxylate

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Conditions
ConditionsYield
With palladium 10% on activated carbon; hydrogen In methanol at 40℃; for 48h;
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

propargyl bromide
106-96-7

propargyl bromide

ethyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate
141403-43-2

ethyl 4-(prop-2-yn-1-yl)piperazine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 0℃; for 1.5h;100%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

teroxirone
2451-62-9

teroxirone

carboxylate protected tris(2,3-epoxypropyl)isocyanurate

carboxylate protected tris(2,3-epoxypropyl)isocyanurate

Conditions
ConditionsYield
In methanol; 1,2-dimethoxyethane at 25℃; for 51h;100%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoic acid
1292849-66-1

4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)methyl]-phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoic acid

ethyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}-piperazine-1-carboxylate
1292849-78-5

ethyl 4-{4-[{4-chloro-2-[(2-chlorophenyl)(hydroxy)-methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}-piperazine-1-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In dichloromethane at 20℃; for 18h;100%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

Cbz-L-Gln
2650-64-8

Cbz-L-Gln

4-((S)-2-benzyloxycarbonylamino-4-carbamoylbutyryl)piperazine-1-carboxylic acid ethyl ester
1021703-31-0

4-((S)-2-benzyloxycarbonylamino-4-carbamoylbutyryl)piperazine-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: Cbz-L-Gln With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran; dichloromethane at 20℃; for 0.0833333h;
Stage #2: 4-ethoxycarbonylpiperazine In tetrahydrofuran; dichloromethane at 20℃; for 24h;		100%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid
71449-08-6

(2R)-2-{[(benzyloxy)carbonyl]amino}-4-tert-butoxy-4-oxobutanoic acid

4-((R)-2-benzyloxycarbonylamino-3-tert-butoxycarbonylpropionyl)piperazine-1-carboxylic acid ethyl ester

4-((R)-2-benzyloxycarbonylamino-3-tert-butoxycarbonylpropionyl)piperazine-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
Stage #1: (R)-2-(((benzyloxy)carbonyl)amino)-4-(tertbutoxy)-4-oxobutanoic acid With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; dichloromethane at 20℃; for 0.25h;
Stage #2: 4-ethoxycarbonylpiperazine In tetrahydrofuran; dichloromethane at 20℃; for 24h;		100%
3-chloromethyl-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole
657424-58-3

3-chloromethyl-5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazole

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

4-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-piperazine-1-carboxylic acid ethyl ester

4-[5-(2-fluoro-5-methyl-phenyl)-[1,2,4]oxadiazol-3-ylmethyl]-piperazine-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With potassium carbonate In acetonitrile at 20℃;99.1%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

7-Chloro-2-methoxy-4-trifluoromethyl-[1,8]naphthyridine
210643-01-9

7-Chloro-2-methoxy-4-trifluoromethyl-[1,8]naphthyridine

4-(7-Methoxy-5-trifluoromethyl-[1,8]naphthyridin-2-yl)-piperazine-1-carboxylic acid ethyl ester
210643-02-0

4-(7-Methoxy-5-trifluoromethyl-[1,8]naphthyridin-2-yl)-piperazine-1-carboxylic acid ethyl ester

Conditions
ConditionsYield
With triethylamine at 100℃; for 24h;98%
2-iodo-propane
75-30-9

2-iodo-propane

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

ethyl 4-(1-methylethyl)piperazine-1-carboxylate
61014-91-3

ethyl 4-(1-methylethyl)piperazine-1-carboxylate

Conditions
ConditionsYield
With potassium carbonate In acetonitrile for 24h; Heating;98%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

C54H96N6O18S2

C54H96N6O18S2

C96H180N18O30S2

C96H180N18O30S2

Conditions
ConditionsYield
In methanol at 20℃; for 24h;98%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

phenyl isothiocyanate
103-72-0

phenyl isothiocyanate

ethyl 4-(phenylthiocarbamoyl)piperazine-1-carboxylate
332033-11-1

ethyl 4-(phenylthiocarbamoyl)piperazine-1-carboxylate

Conditions
ConditionsYield
In diethyl ether for 0.5h;98%
In benzene at 45℃; for 6h; Reflux;85%
4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid azide
1426433-94-4

5-chloro-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid azide

ethyl 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-ylcarbamoyl)piperazine-1-carboxylate

ethyl 4-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-ylcarbamoyl)piperazine-1-carboxylate

Conditions
ConditionsYield
In toluene for 1h; Curtius Rearrangement; Reflux;98%
4-(1H-indazole-3-carboxamido)benzoic acid

4-(1H-indazole-3-carboxamido)benzoic acid

4-ethoxycarbonylpiperazine
120-43-4

4-ethoxycarbonylpiperazine

ethyl 4-[4-(1H-indazole-3-carboxamido)benzoyl]piperazine-1-carboxylate

ethyl 4-[4-(1H-indazole-3-carboxamido)benzoyl]piperazine-1-carboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 16h;98%

Ethyl N-piperazinecarboxylate Consensus Reports

Reported in EPA TSCA Inventory.

Ethyl N-piperazinecarboxylate Specification

The IUPAC name of Ethylcarbonyl piperazine is ethyl piperazine-1-carboxylate. With the CAS registry number 120-43-4, it is also named as Piperazine ethylcarboxylate. The product's categories are Piperidine; Piperidines, Piperidones, Piperazines. Besides, it is clear light yellow oily liquid, which should be stored in sealed, cool, dry place away from combustion source and oxidizing agents. And you should ensure that the workplace has good ventilated devices. In addition, its molecular formula is C7H14N2O2 and molecular weight is 158.20.

The other characteristics of this product can be summarized as: (1)EINECS: 204-395-2; (2)ACD/LogP: -0.14; (3)# of Rule of 5 Violations: 0; (4)ACD/LogD (pH 5.5): -1.98; (5)ACD/LogD (pH 7.4): -0.42; (6)ACD/BCF (pH 5.5): 1; (7)ACD/BCF (pH 7.4): 1; (8)ACD/KOC (pH 5.5): 1; (9)ACD/KOC (pH 7.4): 10.5; (10)#H bond acceptors: 4; (11)#H bond donors: 1; (12)#Freely Rotating Bonds: 2; (13)Index of Refraction: 1.466; (14)Molar Refractivity: 40.94 cm3; (15)Molar Volume: 147.6 cm3; (16)Surface Tension: 35.6 dyne/cm; (17)Density: 1.071 g/cm3; (18)Flash Point: 97.1 °C; (19)Melting point: 120 °C; (20)Enthalpy of Vaporization: 47.38 kJ/mol; (21)Boiling Point: 237 °C at 760 mmHg; (22)Vapour Pressure: 0.0459 mmHg at 25 °C.

Uses of Ethylcarbonyl piperazine: this chmical is mainly used as dye intermediate. Additionally, it can react with Chloromethyl-benzene to get 4-benzyl-πperazine-1-carboxylic acid ethyl ester.



This reaction needs NaHCO3 and aq. Ethanol by heating for 18 hours. The yield is 99 %.

When you are using this chemical, please be cautious about it as the following: it is harmful by inhalation, in contact with skin and if swallowed. Please do not breathe vapour. And you should avoid contact with skin and eyes. Moreover, it is irritating to eyes, respiratory system and skin. In case of contact with eyes, please rinse immediately with plenty of water and seek medical advice. Besides, you can wear suitable protective clothing, gloves and eye/face protection.

People can use the following data to convert to the molecule structure.
(1)SMILES: O=C(OCC)N1CCNCC1
(2)InChI: InChI=1/C7H14N2O2/c1-2-11-7(10)9-5-3-8-4-6-9/h8H,2-6H2,1H3
(3)InChIKey: LNOQURRKNJKKBU-UHFFFAOYAO
(4)Std. InChI: InChI=1S/C7H14N2O2/c1-2-11-7(10)9-5-3-8-4-6-9/h8H,2-6H2,1H3
(5)Std. InChIKey: LNOQURRKNJKKBU-UHFFFAOYSA-N

The toxicity data is as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 138mg/kg (138mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Oyo Yakuri. Pharmacometrics. Vol. 33, Pg. 825, 1987.

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