4-MORPHOLINOBENZOPHENONE

The CAS registry number of Methanone,[4-(4-morpholinyl)phenyl]phenyl- is 24758-49-4. Its EINECS registry number is 246-447-7. The IUPAC name is (4-morpholin-4-ylphenyl)-phenylmethanone. In addition, the molecular formula is C₁₇H₁₇NO₂ and the molecular weight is 267.32. It is also called 4-Morpholinobenzophenone. It is a kind of light green crystalline powder and belongs to the class of Pharmacetical. What's more, it should be stored in sealed container, and placed in a cool and dry environment.

Physical properties about this chemical are: (1)ACD/LogP: 2.56; (2)ACD/LogD (pH 5.5): 2.56; (3)ACD/LogD (pH 7.4): 2.56; (4)ACD/BCF (pH 5.5): 51.54; (5)ACD/BCF (pH 7.4): 51.57; (6)ACD/KOC (pH 5.5): 584.93; (7)ACD/KOC (pH 7.4): 585.22; (8)#H bond acceptors: 3; (9)#Freely Rotating Bonds: 3; (10)Polar Surface Area: 29.54 Å²; (11)Index of Refraction: 1.589; (12)Molar Refractivity: 77.85 cm³; (13)Molar Volume: 230.8 cm³; (14)Polarizability: 30.86 ×10^-24cm³; (15)Surface Tension: 45.1 dyne/cm; (16)Density: 1.157 g/cm³; (17)Flash Point: 226.3 °C; (18)Enthalpy of Vaporization: 70.94 kJ/mol; (19)Boiling Point: 450.5 °C at 760 mmHg; (20)Vapour Pressure: 2.62E-08 mmHg at 25°C.

Preparation of Methanone,[4-(4-morpholinyl)phenyl]phenyl-: it can be prepared by 2-[4-(4-Morpholinyl)phenyl]-2-phenyl-1,3-dithian. This reaction will need reagent HgCl₂/HgO and solvents H₂O and methanol. The reaction time is 12 hours by heating. The yield is about 80%.

Uses of Methanone,[4-(4-morpholinyl)phenyl]phenyl-: it can react with 1-(4-bromo-phenyl)-pyrrolidine to get (4-morpholin-4-yl-phenyl)-phenyl-(4-pyrrolidin-1-yl-phenyl)-methanol. This reaction will need reagent n-BuLi-TMEDA complex and solvent diethyl ether. The reaction time is 45 minutes at reaction temperature of 20 °C by. The yield is about 66%.

When you are using this chemical, please be cautious about it as the following:
During using it, you should avoid contact with skin and eyes.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C(c1ccccc1)c3ccc(N2CCOCC2)cc3
(2)InChI: InChI=1/C17H17NO2/c19-17(14-4-2-1-3-5-14)15-6-8-16(9-7-15)18-10-12-20-13-11-18/h1-9H,10-13H2
(3)InChIKey: CGCQHMFVCNWSOV-UHFFFAOYAW